Adrian Wanner
@adrianawanner.bsky.social
SERI-funded #ERCStG Group Leader at PSI https://structuralneurobiology.ch, CV Starr Fellow at Princeton Neuroscience Institute, founder of https://ariadne.ai
Reposted by Adrian Wanner
Our dispatch:
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
December 16, 2025 at 7:27 AM
Our dispatch:
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
#neuroscience
Reposted by Adrian Wanner
A paper from my PhD lab is on Science! This is a really cool new way to utilize EM connectome datasets. Congrats to the team!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Spatial and morphological organization of mitochondria in neurons across a connectome
Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing th...
www.science.org
December 14, 2025 at 9:46 AM
A paper from my PhD lab is on Science! This is a really cool new way to utilize EM connectome datasets. Congrats to the team!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Adrian Wanner
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
December 9, 2025 at 5:50 PM
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Adrian Wanner
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
December 9, 2025 at 3:37 PM
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
Reposted by Adrian Wanner
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
www.nature.com
December 8, 2025 at 4:59 PM
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Reposted by Adrian Wanner
Connectomics is Method of the Year 2025!!
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
December 8, 2025 at 4:44 PM
Connectomics is Method of the Year 2025!!
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
@natmethods.nature.com
just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...
Connectomics is method of the year 2025:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
www.nature.com
December 8, 2025 at 4:42 PM
Connectomics is method of the year 2025:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adrian Wanner
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
www.nature.com
December 4, 2025 at 8:32 PM
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adrian Wanner
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Adrian Wanner
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods
Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...
www.nature.com
November 27, 2025 at 11:51 AM
#paper!
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
X-rays can resolve #ultrastructure in tissues non-destructively.
www.nature.com/articles/s41...
Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
November 27, 2025 at 10:21 AM
Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...
Reposted by Adrian Wanner
For a decade, my white whale as a neuroscientist has been working to convince public+private funders to "go big" on post-mortem human tissue analysis, so we can define circuit disruptions in disease and just maybe link them with molecular drivers. This remains as tough a sell today as 10 years ago.
November 17, 2025 at 2:23 PM
For a decade, my white whale as a neuroscientist has been working to convince public+private funders to "go big" on post-mortem human tissue analysis, so we can define circuit disruptions in disease and just maybe link them with molecular drivers. This remains as tough a sell today as 10 years ago.
Reposted by Adrian Wanner
Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
November 14, 2025 at 3:22 PM
Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Reposted by Adrian Wanner
Excited to share my most recent postdoctoral work in the Jeanne lab @yaleneuro.bsky.social !
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
Sensory processing reformats odor coding around valence and dynamics
Extracting relevant features of a complex sensory signal typically involves sequential processing through multiple brain regions. However, identifying the logic and mechanisms of these transformations...
www.biorxiv.org
November 9, 2025 at 12:58 PM
Excited to share my most recent postdoctoral work in the Jeanne lab @yaleneuro.bsky.social !
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
Reposted by Adrian Wanner
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
The songbird basal ganglia connectome
The basal ganglia (BG) play an essential role in shaping vertebrate behavior, ranging from motor learning to emotions, but comprehensive maps of their canonical synaptic architecture are missing. In m...
www.biorxiv.org
October 30, 2025 at 6:07 PM
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
Reposted by Adrian Wanner
So proud of my new lab! Check out the recent songbird basal ganglia connectome - great job @alexandrarother.bsky.social !!
@jmrko.bsky.social !!
songbird-connectomics.org
@jmrko.bsky.social !!
songbird-connectomics.org
songbird basal ganglia connectome
songbird-connectomics.org
October 29, 2025 at 5:36 PM
So proud of my new lab! Check out the recent songbird basal ganglia connectome - great job @alexandrarother.bsky.social !!
@jmrko.bsky.social !!
songbird-connectomics.org
@jmrko.bsky.social !!
songbird-connectomics.org
Reposted by Adrian Wanner
Thank you so much @wellcometrust.bsky.social for supporting us to push the the limits of #X-ray #nanoimaging and #connectomics, and to make technology more broadly available to the scientific community! 🙏
ESRF scientist Alexandra Pacureanu is the recipient of the Wellcome Discovery Award, together with a team at the Francis Crick Institute, to develop X-ray nanoimaging technology to study the mechanisms of information processing in the neural circuits of olfaction.
www.esrf.fr/home/news/ge...
www.esrf.fr/home/news/ge...
October 27, 2025 at 5:39 PM
Thank you so much @wellcometrust.bsky.social for supporting us to push the the limits of #X-ray #nanoimaging and #connectomics, and to make technology more broadly available to the scientific community! 🙏
Reposted by Adrian Wanner
Excited to try this! The waiting list makes me even more curious
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 3:56 PM
Excited to try this! The waiting list makes me even more curious
Reposted by Adrian Wanner
The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 3:00 PM
The Crick is an absolutely amazing place to work in - please share this opportunity widely with your colleagues and postdocs - and DM me if I can help in any way
Reposted by Adrian Wanner
Apply now!!! 🔥
October 6, 2025 at 4:44 PM
Apply now!!! 🔥
Reposted by Adrian Wanner
New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…
gcamp6f.com
August 11, 2025 at 12:19 PM
New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i...
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!
Reposted by Adrian Wanner
Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1
September 28, 2025 at 9:15 PM
Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1
Reposted by Adrian Wanner
Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...
Postdoctoral Fellow on high-throughput X-ray laminography
The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy...
www.psi.ch
September 25, 2025 at 11:15 AM
Great opportunity to work with an amazing team on the frontiers of X-ray connectomics www.psi.ch/en/hr/job-op...
Reposted by Adrian Wanner
#Nanoimaging symposium @crick.ac.uk!
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
Hard X-ray imaging of biological soft tissues symposium 2025
tinyurl.com
September 23, 2025 at 10:43 AM
#Nanoimaging symposium @crick.ac.uk!
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
At #CrickXrays25 we'll tackle:
💫synchrotron upgrades
📈current limits in throughput, volume, resolution
🧪sample preparation for X-ray PC imaging
🧠♥️applications in neuroscience and tissue life science
🗓️13th October 2025
🇬🇧🌐 London & online
tinyurl.com/crickxrays25
Reposted by Adrian Wanner
