Angelika Andrzejewska-Romanowska
@aandrzejewskaa.bsky.social
Molecular biologist 👩🔬 IBCH PAS Poznan | PhD interested in #RNAstructure inside the cells and #RNA remodeling factors #mRNA #invivo #retrotransposons
Pinned
Hi! 👋 I'm new here 👋
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
Currently, my most important project 🫠 #babyontheway
June 22, 2025 at 5:23 AM
Currently, my most important project 🫠 #babyontheway
Check out our latest work in Scientific Reports from @natureportfolio.nature.com presenting our guidance for efficient #mRNA enrichment, as a crucial aspect of the transcriptome-wide studies 🙌
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 28, 2025 at 1:18 PM
Check out our latest work in Scientific Reports from @natureportfolio.nature.com presenting our guidance for efficient #mRNA enrichment, as a crucial aspect of the transcriptome-wide studies 🙌
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I can proudly announce that the City of #Poznań awarded me for the best #PhD theses! 👏
It shows that the importance of #RNA research in vivo and #RNA genome dynamics of LTR retrotransposons is understood and appreciated by society! #RNAworld ❤️🧬
www.poznan.pl/mim/info/new...
It shows that the importance of #RNA research in vivo and #RNA genome dynamics of LTR retrotransposons is understood and appreciated by society! #RNAworld ❤️🧬
www.poznan.pl/mim/info/new...
Rozstrzygnięto konkurs na najlepsze prace doktorskie i magisterskie
Już po raz dwudziesty pierwszy Miasto przyznało nagrody za najlepsze prace doktorskie i magisterskie obronione na poznańskich uczelniach i w instytucjach naukowych. W tym roku wyróżnienia odebrało 13 ...
www.poznan.pl
April 18, 2025 at 9:19 AM
Reposted by Angelika Andrzejewska-Romanowska
Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social!
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
Schärfen et al. develop a method to measure the structure of nascent RNAs during their
synthesis by RNA polymerases. Base pairing occurs rapidly in cells, revealing the
strong regulatory potential of ...
www.cell.com
March 26, 2025 at 1:39 PM
Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social!
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
Reposted by Angelika Andrzejewska-Romanowska
New #Breakthrough article from @Woodsonlab.bsky.social shows how the E.coli RNA DEAD-box helicase unfolds unstable RNAs to fuel ribosomal RNA remodeling and the search for the native, protein binding structure! #Ribosome #RNA #Helicase 👉 Full article: https://doi.org/10.1093/nar/gkaf104
February 24, 2025 at 9:29 AM
New #Breakthrough article from @Woodsonlab.bsky.social shows how the E.coli RNA DEAD-box helicase unfolds unstable RNAs to fuel ribosomal RNA remodeling and the search for the native, protein binding structure! #Ribosome #RNA #Helicase 👉 Full article: https://doi.org/10.1093/nar/gkaf104
Reposted by Angelika Andrzejewska-Romanowska
🚨 New #Breakthrough article from @holmqvist-lab.bsky.social: "ProQ prevents mRNA degradation through inhibition of poly(A) polymerase" #RNA #Stability #Degredation #mRNA 📖 Read the full article here: https://doi.org/10.1093/nar/gkaf103
February 27, 2025 at 10:00 AM
🚨 New #Breakthrough article from @holmqvist-lab.bsky.social: "ProQ prevents mRNA degradation through inhibition of poly(A) polymerase" #RNA #Stability #Degredation #mRNA 📖 Read the full article here: https://doi.org/10.1093/nar/gkaf103
Reposted by Angelika Andrzejewska-Romanowska
Dear Polish and European RNA Researchers,
Don’t forget to register for the 2nd Polish RNA Biology Meeting in Poznan, June 24-27! 🧬✨ It’s gonna be an incredible event with an AMAZING lineup of keynote speakers already confirmed! 🎉#RNA
👉 Register here: 2ndrna.web.amu.edu.pl
Don’t forget to register for the 2nd Polish RNA Biology Meeting in Poznan, June 24-27! 🧬✨ It’s gonna be an incredible event with an AMAZING lineup of keynote speakers already confirmed! 🎉#RNA
👉 Register here: 2ndrna.web.amu.edu.pl
Home - 2nd Polish RNA Meeting
2ndrna.web.amu.edu.pl
February 25, 2025 at 1:31 PM
Dear Polish and European RNA Researchers,
Don’t forget to register for the 2nd Polish RNA Biology Meeting in Poznan, June 24-27! 🧬✨ It’s gonna be an incredible event with an AMAZING lineup of keynote speakers already confirmed! 🎉#RNA
👉 Register here: 2ndrna.web.amu.edu.pl
Don’t forget to register for the 2nd Polish RNA Biology Meeting in Poznan, June 24-27! 🧬✨ It’s gonna be an incredible event with an AMAZING lineup of keynote speakers already confirmed! 🎉#RNA
👉 Register here: 2ndrna.web.amu.edu.pl
Reposted by Angelika Andrzejewska-Romanowska
🚀 New Paper Alert! 🚀
𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure
Check it out in @narjournal.bsky.social:
academic.oup.com/nar/article/...
Here’s why you should give it a try 🧵👇
𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure
Check it out in @narjournal.bsky.social:
academic.oup.com/nar/article/...
Here’s why you should give it a try 🧵👇
February 10, 2025 at 2:38 PM
🚀 New Paper Alert! 🚀
𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure
Check it out in @narjournal.bsky.social:
academic.oup.com/nar/article/...
Here’s why you should give it a try 🧵👇
𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure
Check it out in @narjournal.bsky.social:
academic.oup.com/nar/article/...
Here’s why you should give it a try 🧵👇
Reposted by Angelika Andrzejewska-Romanowska
I am glad to share that our study on RNA-protein interactions in the brain affected by myelin deficiency has been published in the latest
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination
Myelin deficiency in the central nervous system leads to severe neurological dysfunctions.
Sztachera et al. probe RNA-protein interactions in the myelin-deficient mouse brain
in a high-throughput mann...
www.cell.com
January 31, 2025 at 1:43 PM
I am glad to share that our study on RNA-protein interactions in the brain affected by myelin deficiency has been published in the latest
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Cell Reports issue.
😊🤠
Except for insights into RBPs, you will find there also something about circRNAs (of course!) :)
www.cell.com/cell-reports...
Reposted by Angelika Andrzejewska-Romanowska
Amazing new paper from @rivaselenarivas.bsky.social keeps improving #RNA covariation analysis, by adding RNA 3D motif prediction from alignment in R-scape!
Inaugural post "All-at-one RNA folding with 3D motif prediction framed by evolutionary information" www.biorxiv.org/content/10.1...
Introducing CaCoFold-R3D by
@aakaran31.bsky.social and myself @rivaselenarivas.bsky.social
Introducing CaCoFold-R3D by
@aakaran31.bsky.social and myself @rivaselenarivas.bsky.social
All-at-once RNA folding with 3D motif prediction framed by evolutionary information
Structural RNAs exhibit a vast array of recurrent short 3D elements involving non-Watson-Crick interactions that help arrange canonical double helices into tertiary structures. We present CaCoFold-R3D...
www.biorxiv.org
January 8, 2025 at 10:23 AM
Amazing new paper from @rivaselenarivas.bsky.social keeps improving #RNA covariation analysis, by adding RNA 3D motif prediction from alignment in R-scape!
Today, the "PhD" chapter is officially finished with a great success! ✨👩🎓💫
And a diploma for my birthday! 🎂
And a diploma for my birthday! 🎂
December 16, 2024 at 9:03 PM
Today, the "PhD" chapter is officially finished with a great success! ✨👩🎓💫
And a diploma for my birthday! 🎂
And a diploma for my birthday! 🎂
Reposted by Angelika Andrzejewska-Romanowska
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
December 11, 2024 at 9:14 AM
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
The future is now! 🙌 An Interpretable RNA Foundation Model for Exploration Functional RNA Motifs in Plants was published in Nature Machine Intelligence by prof. Yiliang Ding group! Congratulations to the Authors 👏
www.nature.com/articles/s42...
www.nature.com/articles/s42...
An interpretable RNA foundation model for exploring functional RNA motifs in plants - Nature Machine Intelligence
Approaches are needed to explore regulatory RNA motifs in plants. An interpretable RNA foundation model is developed, trained on thousands of plant transcriptomes, which achieves superior performance ...
www.nature.com
December 11, 2024 at 3:10 PM
The future is now! 🙌 An Interpretable RNA Foundation Model for Exploration Functional RNA Motifs in Plants was published in Nature Machine Intelligence by prof. Yiliang Ding group! Congratulations to the Authors 👏
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Angelika Andrzejewska-Romanowska
Reposted by Angelika Andrzejewska-Romanowska
Very small RNA-reactive reagents can map RNA in crowded spaces in the cell -
congrats to Dr. Lu Xiao!
doi: 10.1016/j.chembiol.2024.09.009
congrats to Dr. Lu Xiao!
doi: 10.1016/j.chembiol.2024.09.009
November 25, 2024 at 4:53 PM
Very small RNA-reactive reagents can map RNA in crowded spaces in the cell -
congrats to Dr. Lu Xiao!
doi: 10.1016/j.chembiol.2024.09.009
congrats to Dr. Lu Xiao!
doi: 10.1016/j.chembiol.2024.09.009
Reposted by Angelika Andrzejewska-Romanowska
🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...
A quantitative framework for structural interpretation of DMS reactivity
Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite i...
www.biorxiv.org
November 25, 2024 at 3:42 PM
🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...
Reposted by Angelika Andrzejewska-Romanowska
To correlate DMS reactivity with RNA structure, we built a massive library of 7,500 RNA constructs containing multiple junctions with known 3D structures. Our measurements are highly reproducible (R²=0.99), span four orders of magnitude, and reveal that RNA motifs have unique DMS profiles.
November 25, 2024 at 3:45 PM
To correlate DMS reactivity with RNA structure, we built a massive library of 7,500 RNA constructs containing multiple junctions with known 3D structures. Our measurements are highly reproducible (R²=0.99), span four orders of magnitude, and reveal that RNA motifs have unique DMS profiles.
Reposted by Angelika Andrzejewska-Romanowska
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
November 21, 2024 at 2:56 PM
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
Reposted by Angelika Andrzejewska-Romanowska
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Angelika Andrzejewska-Romanowska
The final version of our article describing a modernized procedure for cotranscriptional RNA structure probing is online! www.nature.com/articles/s41...
Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing ...
RNA begins to fold as the nascent transcript emerges from a transcribing RNA polymerase. Here, the authors develop a concise method for mapping RNA folding pathways that couples in vitro transcription...
www.nature.com
November 29, 2023 at 2:46 PM
The final version of our article describing a modernized procedure for cotranscriptional RNA structure probing is online! www.nature.com/articles/s41...
Reposted by Angelika Andrzejewska-Romanowska
#RNA #RNAsky
Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world
rna2drawer.app
RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...
Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world
rna2drawer.app
RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...
RNAcanvas: interactive drawing and exploration of nucleic acid structures
Abstract. Two-dimensional drawing of nucleic acid structures, particularly RNA structures, is fundamental to the communication of nucleic acids research. H
academic.oup.com
November 13, 2024 at 11:20 PM
#RNA #RNAsky
Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world
rna2drawer.app
RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...
Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world
rna2drawer.app
RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...
Reposted by Angelika Andrzejewska-Romanowska
A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...
Accurate RNA 3D structure prediction using a language model-based deep learning approach - Nature Methods
RhoFold+ is an end-to-end language model-based deep learning method to predict RNA three-dimensional structures of single-chain RNAs from sequences.
www.nature.com
November 21, 2024 at 3:15 PM
A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...
I'd like to show you the graphic I created 🎨 and was recently chosen for the cover of Nucleic Acids Research 💫
I want to have it here!
This cover is an extraordinary honor for me and shows me that it is worth trying even if the chances are small!
Related study here 👇
academic.oup.com/nar/article/...
I want to have it here!
This cover is an extraordinary honor for me and shows me that it is worth trying even if the chances are small!
Related study here 👇
academic.oup.com/nar/article/...
November 20, 2024 at 5:06 PM
I'd like to show you the graphic I created 🎨 and was recently chosen for the cover of Nucleic Acids Research 💫
I want to have it here!
This cover is an extraordinary honor for me and shows me that it is worth trying even if the chances are small!
Related study here 👇
academic.oup.com/nar/article/...
I want to have it here!
This cover is an extraordinary honor for me and shows me that it is worth trying even if the chances are small!
Related study here 👇
academic.oup.com/nar/article/...
Hi! 👋 I'm new here 👋
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
November 20, 2024 at 4:49 PM
Hi! 👋 I'm new here 👋
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!
I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)!
1📎 academic.oup.com/nar/article/...
2📎 academic.oup.com/nar/article/...
The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!