Gracjan Michlewski
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gmichlew.bsky.social
Gracjan Michlewski
@gmichlew.bsky.social
#RNA scientist
Reposted by Gracjan Michlewski
🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬

👉Read the story: bit.ly/3XYvQkI

#Nature #mRNA
IIMCB
bit.ly
April 16, 2025 at 6:00 PM
Reposted by Gracjan Michlewski
👋 Hello BlueSky! We’re the International Institute of Molecular and Cell Biology in Warsaw – a research institute at the forefront of life sciences. Our scientists explore the molecular and cellular mechanisms of life, combining curiosity-driven research with scientific and societal relevance.
April 15, 2025 at 1:43 PM
TRIM25 takes a centre stage! Right in the context of its RNA-binding role. Exogenous RNA surveillance by proton-sensing TRIM25 | Science www.science.org/doi/abs/10.1...
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
April 6, 2025 at 12:55 PM
Dear Polish and European RNA Researchers,
Don’t forget to register for the 2nd Polish RNA Biology Meeting in Poznan, June 24-27! 🧬✨ It’s gonna be an incredible event with an AMAZING lineup of keynote speakers already confirmed! 🎉#RNA

👉 Register here: 2ndrna.web.amu.edu.pl
Home - 2nd Polish RNA Meeting
2ndrna.web.amu.edu.pl
February 25, 2025 at 1:31 PM
I would like to thank the whole team, especially Nathalie Idlin and Sivakumar Krishnamoorthy (joint first authors) for the great effort! Also, I would like to thank IIMCB www.iimcb.gov.pl/en/, NCN www.ncn.gov.pl and NAWA nawa.gov.pl for their generous support and funding!
IIMCB
www.iimcb.gov.pl
January 24, 2025 at 9:22 AM
RNA-protein interactions were once thought to be undruggable 💊🔬In our latest study, we show how the FDA-approved drug Eltrombopag disrupts HuR/RNA interactions, altering translation, iron metabolism, and hormone levels 🧬 #RNA #Protein #DrugDiscovery

bmcbiol.biomedcentral.com/articles/10....
Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels - BMC Biology
Background HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the RNA-binding protein family and is crucial for stabilizing and regulating the translation of various mRNA targets, influencing gen...
bmcbiol.biomedcentral.com
January 24, 2025 at 9:19 AM
Reposted by Gracjan Michlewski
January 10, 2025 at 10:37 PM
Reposted by Gracjan Michlewski
Not far away at HHMI. This is how we do it now @hhmi.bsky.social. HHMI Investigator reviews and all competitions consider pre-prints equivalent to peer-reviewed articles. No reason that this can't be the norm everywhere.
December 22, 2024 at 2:01 PM
In vitro transcription (IVT) is a technology that facilitated the production of mRNA therapeutics and drove numerous breakthroughs in RNA biology. Our new study uncovers unexpected insights into the immunogenicity of in IVT RNAs. #RNA #IVT #Immunity

academic.oup.com/nar/advance-...
5′ terminal nucleotide determines the immunogenicity of IVT RNAs
Abstract. In vitro transcription (IVT) is a technology of vital importance that facilitated the production of mRNA therapeutics and drove numerous breakthr
academic.oup.com
December 20, 2024 at 6:52 PM
Reposted by Gracjan Michlewski
This is a lovely piece about the 2024 Nobel Prize to Victor Ambros and Gary Ruvkun, written by Bruce Wightman, the first author of one of the prize-winning papers. It emphasizes the importance of fundamental research and the beauty of heterochronic genes. #Celegans #devbio 🧪🧬 doi.org/10.1242/dmm....
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
Summary: The 2024 Nobel Prize in Physiology or Medicine has been awarded for the discovery of miRNAs; the groundwork was laid by investigating the timing of developmental events in nematodes.
doi.org
November 27, 2024 at 2:51 PM
I will not even deny it :))) Scholar Goggler
November 22, 2024 at 9:55 AM
Reposted by Gracjan Michlewski
Co wyniknie z dzisiejszego spotkania Komisji Finansów Publicznych? #TakDlaNauki i #TakDlaRozwoju czy trzymanie naszego kraju na poziomie taniej montowni?
#NCNtoTlen
@dariuszwieczorek.bsky.social
@andrzej-domanski.bsky.social
@donald-tusk.bsky.social
@radek-sikorski.bsky.social
November 20, 2024 at 9:32 AM
Exciting Opportunity: IIMCB is hiring a Junior Group Leader in Computational Biology to establish an independent research group. Join us in Warsaw!💻 🌍
🔗Full job offer: bit.ly/4fzXJWO
#JoinOurTeam #IIMCB #ComputationalBiology #ResearchOpportunity #CareersInScience
IIMCB
bit.ly
November 19, 2024 at 11:09 AM
🔬🧫 🧬 Are you looking for an opportunity to set up your own laboratory focused on RNA or cell biology in an inspiring environment surrounded by like-minded researchers? The IIMCB in Warsaw is offering an excellent opportunity
www.rnasociety.org/junior-group... www.iimcb.gov.pl/en/ #CellBiology #RNA
Junior Group Leader Professor position
www.rnasociety.org
November 11, 2024 at 5:52 PM
Hey everyone!
November 10, 2024 at 12:33 PM