It was pleasure to host my former lab mate Noor Jailkhani from Matrisome Bio yesterday at The University of Connecticut School of Medicine. Not many can say that they both developed a new technology hands on, and then led this into the market as the CEO of a successful company.

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?

rdcu.be/eN1jm

Happy to share an exciting paper from my former lab mate, Jess Hebert, showing Cas12 efficacy and use in somatic screening. Take a look if you are considering the approach! www.nature.com/articles/s41...

Despite strong headwinds, we are continuing to do our work. Congratulations to lead author Ashok Cheemala. Here, Ashok shows that even a single point mutation in TDP-43 leads to large defects in cell-cell junction and barrier www.science.org/doi/10.1126/...

I'm happy to announce that our paper describing the first in human tissue application of inCITE-seq, to assess nuclear levels of RNA-binding proteins, and key regulators of the blood brain barrier (b-Catenin and NF-kB) is now available online from Nature Neuroscience www.nature.com/articles/s41...

www.motherjones.com/politics/202...

www.science.org/doi/10.1126/...

A source close to the situation confirmed that study sections are continuing to be cancelled. On the chopping block this week: developmental brain disorders, mechanisms of cancer therapy, and neurotoxicology of alcohol. For some labs, this was the last chance to get funding or they’ll shut down.

Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts

www.nature.com/articles/s41...

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases

www.nature.com/articles/s41...

Have you wondered if there is a role for the endothelium in regulating immune responses, beyond its function as a gatekeeper? Here, we molecularly define an immune transition of the endothelium required for chronic CD8 T cell responses in atherosclerosis www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...
Interesting new work showing vascular cholesterol metabolism as a negative feedback on neurovascular coupling.

New preprints from our lab! biorxiv.org/cgi/content/... and biorxiv.org/cgi/content/... which show that the RNA-binding protein TDP-43 is reduced in the endothelium in neurodegenerative diseases AD and ALS/FTD, and that this reduction can cause BBB disruption.

Interesting new paper identifying somatic mutations in ALS:

www.biorxiv.org/content/10.1...

Please repost: an exciting tenure track position for cardiovascular biologists at the UConn School of Medicine : www.nature.com/naturecareer...
This is an excellent and strongly collaborative and supportive environment to begin your career in!

SMAD4 promotes formation of terminally differentiated CTLs that localize in the microvasculature of the lungs but are excluded from the lumen of the airways https://www.biorxiv.org/content/10.1101/2023.11.16.567437v1