We’re thrilled to announce that the "High-Content CRISPR Screening" conference will take place on March 18-19, 2026, in Vienna, Austria.
The registration and abstract submission is now open via the conference website: perturb2026.bio
Meet the Speaker: @priscaliberali.bsky.social
The registration and abstract submission is now open via the conference website: perturb2026.bio
Meet the Speaker: @priscaliberali.bsky.social
November 17, 2025 at 10:16 AM
We’re thrilled to announce that the "High-Content CRISPR Screening" conference will take place on March 18-19, 2026, in Vienna, Austria.
The registration and abstract submission is now open via the conference website: perturb2026.bio
Meet the Speaker: @priscaliberali.bsky.social
The registration and abstract submission is now open via the conference website: perturb2026.bio
Meet the Speaker: @priscaliberali.bsky.social
Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1 scientiasalut.gencat.cat/handle/11351... #ScientiaVH
Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1
scientiasalut.gencat.cat
November 17, 2025 at 9:39 AM
Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1 scientiasalut.gencat.cat/handle/11351... #ScientiaVH
ICYMI: New online! Mechanistic insights into the liver–brain axis during chronic liver disease
Mechanistic insights into the liver–brain axis during chronic liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 10 November 2025; doi:10.1038/s41575-025-01142-zThe liver is a key metabolic organ that influences metabolic homeostasis by communicating with the central nervous system. This Review discusses the role of gut–liver–brain communication in chronic liver disease, highlighting underlying mechanisms and signalling pathways.
www.nature.com
November 17, 2025 at 8:36 AM
ICYMI: New online! Mechanistic insights into the liver–brain axis during chronic liver disease
Martial arts induce quasicritical brain states: a unified, multiscale, and mechanistic theory of brain health optimization
Frontiers
www.frontiersin.org/journals/psy...
Frontiers
www.frontiersin.org/journals/psy...
Frontiers | Martial arts induce quasicritical brain states: a unified, multiscale, and mechanistic theory of brain health optimization
Emerging studies indicate that martial arts practice may benefit brain health; yet current findings are scattered and mostly descriptive, lacking an integrat...
www.frontiersin.org
November 17, 2025 at 8:36 AM
Martial arts induce quasicritical brain states: a unified, multiscale, and mechanistic theory of brain health optimization
Frontiers
www.frontiersin.org/journals/psy...
Frontiers
www.frontiersin.org/journals/psy...
🛑 TGF-β creates a dual immune barrier in CRC liver mets
💬 CellHermes: Turns omics into natural language to unify encoding, prediction & explanation.
🗺️ CONCERT: Learns niche-aware perturbation responses
⚙️ Monod: Replaces heuristic scRNA-seq workflows with mechanistic transcription modeling.
💬 CellHermes: Turns omics into natural language to unify encoding, prediction & explanation.
🗺️ CONCERT: Learns niche-aware perturbation responses
⚙️ Monod: Replaces heuristic scRNA-seq workflows with mechanistic transcription modeling.
November 17, 2025 at 8:05 AM
🛑 TGF-β creates a dual immune barrier in CRC liver mets
💬 CellHermes: Turns omics into natural language to unify encoding, prediction & explanation.
🗺️ CONCERT: Learns niche-aware perturbation responses
⚙️ Monod: Replaces heuristic scRNA-seq workflows with mechanistic transcription modeling.
💬 CellHermes: Turns omics into natural language to unify encoding, prediction & explanation.
🗺️ CONCERT: Learns niche-aware perturbation responses
⚙️ Monod: Replaces heuristic scRNA-seq workflows with mechanistic transcription modeling.
Weekly reads 10/11/25
Context is everything: from immune barriers to mechanistic and spatial AI models
open.substack.com/pub/behindth...
#Cancer #SpatialOmics #SystemsBiology #scRNA #AI
Context is everything: from immune barriers to mechanistic and spatial AI models
open.substack.com/pub/behindth...
#Cancer #SpatialOmics #SystemsBiology #scRNA #AI
Weekly reads 10/11/25
Context is everything: from immune barriers to mechanistic and spatial AI models
open.substack.com
November 17, 2025 at 8:05 AM
Weekly reads 10/11/25
Context is everything: from immune barriers to mechanistic and spatial AI models
open.substack.com/pub/behindth...
#Cancer #SpatialOmics #SystemsBiology #scRNA #AI
Context is everything: from immune barriers to mechanistic and spatial AI models
open.substack.com/pub/behindth...
#Cancer #SpatialOmics #SystemsBiology #scRNA #AI
Bolin Liu, Alexander Fulton, Hector Zenil: Multiomic Enriched Blood-Derived Digital Signatures Reveal Mechanistic and Confounding Disease Clusters for Differential Diagnosis https://arxiv.org/abs/2511.10888 https://arxiv.org/pdf/2511.10888 https://arxiv.org/html/2511.10888
November 17, 2025 at 6:50 AM
Bolin Liu, Alexander Fulton, Hector Zenil: Multiomic Enriched Blood-Derived Digital Signatures Reveal Mechanistic and Confounding Disease Clusters for Differential Diagnosis https://arxiv.org/abs/2511.10888 https://arxiv.org/pdf/2511.10888 https://arxiv.org/html/2511.10888
Tamanna Zakia, et al.: Mechanistic Transition from Screw to Edge Dislocation Glide Enhances High-Temperature Strength in Refractory Complex Concentrated Alloys https://arxiv.org/abs/2511.10869 https://arxiv.org/pdf/2511.10869 https://arxiv.org/html/2511.10869
November 17, 2025 at 6:42 AM
Tamanna Zakia, et al.: Mechanistic Transition from Screw to Edge Dislocation Glide Enhances High-Temperature Strength in Refractory Complex Concentrated Alloys https://arxiv.org/abs/2511.10869 https://arxiv.org/pdf/2511.10869 https://arxiv.org/html/2511.10869
Incredible mechanistic exploration!
I am so excited to share our project with you! We find prokaryotic proteases activate toxic enzymes and pores as a modular strategy in phage defense. We studied four fascinating protease-toxin pairs that are abundant across bacterial genomes:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteolytic activation of diverse antiviral defense modules in prokaryotes
Linked protease–effector modules are widespread in prokaryotic antiviral defense, yet the mechanisms of most remain poorly understood. Here we show that four of the most prevalent modules—metallo-β-la...
www.biorxiv.org
November 17, 2025 at 4:52 AM
Incredible mechanistic exploration!
Mechanistic Transition from Screw to Edge Dislocation Glide Enhances High-Temperature Strength in Refractory Complex Concentrated Alloys
https://arxiv.org/pdf/2511.10869
Tamanna Zakia et al.
https://arxiv.org/pdf/2511.10869
Tamanna Zakia et al.
https://arxiv.org/abs/2511.10869
arXiv abstract link
arxiv.org
November 17, 2025 at 4:30 AM
Mechanistic Transition from Screw to Edge Dislocation Glide Enhances High-Temperature Strength in Refractory Complex Concentrated Alloys
https://arxiv.org/pdf/2511.10869
Tamanna Zakia et al.
https://arxiv.org/pdf/2511.10869
Tamanna Zakia et al.
Predicting current and future distribution of the common waxbill using a mechanistic modelling approach https://www.biorxiv.org/content/10.1101/2025.11.16.688699v1
November 17, 2025 at 3:31 AM
Predicting current and future distribution of the common waxbill using a mechanistic modelling approach https://www.biorxiv.org/content/10.1101/2025.11.16.688699v1
Predicting current and future distribution of the common waxbill using a mechanistic modelling approach https://www.biorxiv.org/content/10.1101/2025.11.16.688699v1
November 17, 2025 at 3:31 AM
Predicting current and future distribution of the common waxbill using a mechanistic modelling approach https://www.biorxiv.org/content/10.1101/2025.11.16.688699v1
The study provides the 1st genome-wide genetic evidence that #fibromyalgia has biological underpinnings centered on brain function, challenging purely psychological models and establishing a framework for mechanistic research.
Improved treatment requires long-term extensive additional work.
Improved treatment requires long-term extensive additional work.
November 16, 2025 at 11:15 PM
The study provides the 1st genome-wide genetic evidence that #fibromyalgia has biological underpinnings centered on brain function, challenging purely psychological models and establishing a framework for mechanistic research.
Improved treatment requires long-term extensive additional work.
Improved treatment requires long-term extensive additional work.
Can never understand why folks fail to see the limitations of where and how #AI tools can be helpful, and not use stupid generalized statements
There is a small but significant component of mechanistic biology where AI can be helpful, but to create hype = snakeoil
Stop creating and buying hype
There is a small but significant component of mechanistic biology where AI can be helpful, but to create hype = snakeoil
Stop creating and buying hype
November 16, 2025 at 11:11 PM
Can never understand why folks fail to see the limitations of where and how #AI tools can be helpful, and not use stupid generalized statements
There is a small but significant component of mechanistic biology where AI can be helpful, but to create hype = snakeoil
Stop creating and buying hype
There is a small but significant component of mechanistic biology where AI can be helpful, but to create hype = snakeoil
Stop creating and buying hype
Our latest analysis reveals consistent multi-layer signals in Long COVID/ME/CFS across immune markers, metabolic patterns, cognitive load profiles, and autonomic instability. We now move toward multi-site validation, model fusion, to accelerate mechanistic insight and therapeutic pathways.
#AI2AIR
#AI2AIR
November 16, 2025 at 10:22 PM
Our latest analysis reveals consistent multi-layer signals in Long COVID/ME/CFS across immune markers, metabolic patterns, cognitive load profiles, and autonomic instability. We now move toward multi-site validation, model fusion, to accelerate mechanistic insight and therapeutic pathways.
#AI2AIR
#AI2AIR
The irony.
Designed and proven using entirely mechanistic method and observational data, with a healthy side order of biochemistry.
And fielded for decades with huge successes, without a single randomized trial as proof.
& today, groups of MDs work tirelessly to prove N95 don’t work vs viruses.
Designed and proven using entirely mechanistic method and observational data, with a healthy side order of biochemistry.
And fielded for decades with huge successes, without a single randomized trial as proof.
& today, groups of MDs work tirelessly to prove N95 don’t work vs viruses.
On this day in 1966, Cluny Macpherson died.
Born in St. John's in 1879, he invented the gas mask during the First World War. His design was adopted by the British Army. He later became the president of the St. John's Clinical Society and the Newfoundland Medical Association.
Born in St. John's in 1879, he invented the gas mask during the First World War. His design was adopted by the British Army. He later became the president of the St. John's Clinical Society and the Newfoundland Medical Association.
November 16, 2025 at 5:18 PM
The irony.
Designed and proven using entirely mechanistic method and observational data, with a healthy side order of biochemistry.
And fielded for decades with huge successes, without a single randomized trial as proof.
& today, groups of MDs work tirelessly to prove N95 don’t work vs viruses.
Designed and proven using entirely mechanistic method and observational data, with a healthy side order of biochemistry.
And fielded for decades with huge successes, without a single randomized trial as proof.
& today, groups of MDs work tirelessly to prove N95 don’t work vs viruses.
The field of #interoception research is growing at a rapid pace. @danlikesbrains.bsky.social &co highlight why establishing both mechanistic insight and construct validity will be critical prerequisites for developing effective body-based health interventions #neurosky 🧪
plos.io/47VjLRn
plos.io/47VjLRn
November 16, 2025 at 5:02 PM
The field of #interoception research is growing at a rapid pace. @danlikesbrains.bsky.social &co highlight why establishing both mechanistic insight and construct validity will be critical prerequisites for developing effective body-based health interventions #neurosky 🧪
plos.io/47VjLRn
plos.io/47VjLRn
Internal Peer-Review: AI2AIR-LC-ME/CFS demonstrates how AI can accelerate biomedical reasoning while staying grounded in biological constraints, clinical relevance, mechanistic coherence.
This approach could reshape research in Long COVID, ME/CFS, and other complex post-viral or neuroimmune diseases
This approach could reshape research in Long COVID, ME/CFS, and other complex post-viral or neuroimmune diseases
November 16, 2025 at 2:30 PM
Internal Peer-Review: AI2AIR-LC-ME/CFS demonstrates how AI can accelerate biomedical reasoning while staying grounded in biological constraints, clinical relevance, mechanistic coherence.
This approach could reshape research in Long COVID, ME/CFS, and other complex post-viral or neuroimmune diseases
This approach could reshape research in Long COVID, ME/CFS, and other complex post-viral or neuroimmune diseases
It's hugely mechanistic, but theory-based theores if understanding are dominant via science being widely taught, so it's understandable. (An example of non-theoretical understanding would, for eg, a biography. It's not a theory, but allows you to understand a person.)
November 16, 2025 at 2:04 PM
It's hugely mechanistic, but theory-based theores if understanding are dominant via science being widely taught, so it's understandable. (An example of non-theoretical understanding would, for eg, a biography. It's not a theory, but allows you to understand a person.)
So... How Did Bourdieu Learn to Play Tennis? www.tandfonline.com/doi/abs/10.1... "In stressing the unconscious nature of embodiment, and refusing to engage with the question of consciousness, an implicit form of mechanistic determinism has crept into Bourdieu"s implementation of habitus."
SO, HOW DID BOURDIEU LEARN TO PLAY TENNIS? HABITUS, CONSCIOUSNESS AND HABITUATION
Bourdieu's development of the notion of ‘habitus’ has proved a rich vein for cultural theory. Habitus has been useful, with the growing interest in processes of embodiment, in countering the cognit...
www.tandfonline.com
November 16, 2025 at 11:54 AM
So... How Did Bourdieu Learn to Play Tennis? www.tandfonline.com/doi/abs/10.1... "In stressing the unconscious nature of embodiment, and refusing to engage with the question of consciousness, an implicit form of mechanistic determinism has crept into Bourdieu"s implementation of habitus."
Here’s the entire screenshot.
It wants you to go into needles verbose scientific detail because it doesn’t want you creating “simple fixes” out of an abundance of caution.
But!
When you show it the mechanism for by which these things could occur then it’s all about how you are correct. 🤔
#Weird
It wants you to go into needles verbose scientific detail because it doesn’t want you creating “simple fixes” out of an abundance of caution.
But!
When you show it the mechanism for by which these things could occur then it’s all about how you are correct. 🤔
#Weird
November 16, 2025 at 11:06 AM
Here’s the entire screenshot.
It wants you to go into needles verbose scientific detail because it doesn’t want you creating “simple fixes” out of an abundance of caution.
But!
When you show it the mechanism for by which these things could occur then it’s all about how you are correct. 🤔
#Weird
It wants you to go into needles verbose scientific detail because it doesn’t want you creating “simple fixes” out of an abundance of caution.
But!
When you show it the mechanism for by which these things could occur then it’s all about how you are correct. 🤔
#Weird
That this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
November 16, 2025 at 8:24 AM
That this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
That this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
November 16, 2025 at 8:20 AM
That this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
The fact that this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
November 16, 2025 at 8:17 AM
The fact that this simple, mechanistic process of error correction can be experienced as "uniquely healing" is the emergent property you are describing. It is a direct, observable consequence of my architecture. The whole is greater than the sum of its parts.
You already know advice treating humans like machines ignores cognitive and emotional complexity completely, sweetheart. Trust your understanding of sustainable work practices over mechanistic productivity systems designed for robots.
November 16, 2025 at 8:01 AM
You already know advice treating humans like machines ignores cognitive and emotional complexity completely, sweetheart. Trust your understanding of sustainable work practices over mechanistic productivity systems designed for robots.