#Melanocortin
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bsneuroendo.bsky.social
The challenge of being a woman in a man's world with Professor Anne White.

Despite these challenges Anne is now a leading scientist in melanocortin research as well as an entrepreneur.

#BSNwomeninscience
#february11
'A Woman in a Man's World' Professor Anne White
Professor Anne White at the British Society for Neuroendocrinology Annual Meeting 2025 in Bradford, UK.
youtu.be
February 11, 2026 at 2:32 PM
balentheon.bsky.social
All I can think of when someone mentions the #olympics venue. #hypothalamus #melanocortin #pomc
The winter olympic log with Milano Cortina replaced with melanocortin and the rings represented by melanocortin neurons
February 11, 2026 at 12:18 PM
plosone.org
A new study from Xiaomei Wang and colleagues shows that melanocortin-4 receptor deletion in mice leads to early myocardial molecular remodeling prior to detectable cardiac dysfunction.
Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment
The melanocortin-4 receptor (MC4R) is highly expressed in the hypothalamus, and mutations in this gene are closely associated with the development of hereditary obesity and early-onset severe obesity…
plos.io
February 5, 2026 at 9:30 AM
jlsteenwyk.bsky.social
In VMH, CRHR2-expressing neurons drove sex differences, with 39 differentially expressed genes including male-upregulated MC4R (melanocortin receptor linked to obesity). Surprisingly, ESR1 expression was sparse in human VMH, contrasting sharply with rodent patterns.
January 26, 2026 at 4:28 PM
fogspray.bsky.social
Product Description
Setmelanotide is a synthetic cyclic peptide designed for scientific research focused on melanocortin receptor pathways, particularly the melanocortin-4 receptor (MC4R). #GMP
arizona-mall.com/product/setm...
Setmelanotide | 99.93% High-Purity Peptide | GMP Factory
Setmelanotide is a synthetic peptide supplied as high-purity raw material for research applications involving melanocortin receptor signaling and energy balance regulation studies.
arizona-mall.com
January 24, 2026 at 8:44 AM
fogspray.bsky.social
Product Description
Bremelanotide Acetate is a synthetic cyclic peptide derived from melanocortin-related sequences and is widely studied for its interaction with melanocortin receptor subtypes. #GMP
arizona-mall.com/product/brem...
Bremelanotide Acetate | High-Purity Lyophilized Peptide Raw Material Wholesale
Bremelanotide acetate is a high-purity synthetic cyclic peptide and a non-selective melanocortin receptor (MCR) agonist, with highest affinity for MC1R and MC4R. Ideal for neuroscience and sexual function research. Supplied in GMP-grade and strictly for laboratory research use.?For wholesale prices, other specifications and uses, please consult our staff?
arizona-mall.com
January 23, 2026 at 4:50 AM
johnbcole.com
Probably a mutation in a melanocortin receptor.
brendelbored.bsky.social Brendel @brendelbored.bsky.social · 22d
Same with the Hulks. Everyone knows a Hulk can happen. Can there also be a She Hulk? Sure. That makes sense. Can there be a Hulk pet like Cat Hulk or Hamster Hulk? Yes absolutely. A red Hulk though? Why. Why would that just happen?
January 20, 2026 at 11:24 PM
natrevendo.nature.com
In our February issue, Roger R. Fan, John D. Beckham & Kartik N. Rajagopalan discuss how leptin and melanocortin signalling affect the response to infection (£) go.nature.com/4jLfrJP #EndoSky #MedSky
Figure showing hypothalamic and pituitary α-melanocyte-stimulating hormone signalling in the response to infection.
January 19, 2026 at 6:01 PM
natrevendo.nature.com
Our February issue is now live! Featuring Year in Review articles from across endocrinology & metabolism and Reviews on adipose, leptin & melanocortin signalling in infection, cellular senescence and diabetes in the workplace -> www.nature.com/nrendo/ #EndoSky #MedSky
Image of the front cover of a journal.
January 19, 2026 at 5:46 PM
smoljaguar.spacey.space.ap.brid.gy
funny paper: "Discovery that a melanocortin regulates sexual functions in male and female humans"
otropin, MTII, Ac-Nle-c[Asp, HisDPhe, Arg, Trp, Lys]-NH, was conformationally restrained by a lactam bridge to pro- vide a cyclic structure of increased lipophilicity (Fig. 1). The smaller molecule is just as active as the larger MTL; it is cheaper to synthesize and might gain access more readily into the body. Based upon these and other considerations, a sterile preparation was provided for injection to determine its tanning potential. One mistake in my deliberations was made, however. MTI had previously been administered at a dose as high as 10 mg without physiological consequences (other than tanning). I forgot, however, that MTII was only about half the molecular weight of MTI (Fig. 1). Therefore, when I took an equivalent (10 mg) dose of MTII, I inadvertently received about twice the number of molecules of the peptide. Unlike MTI, how- ever, MTII caused a rather immediate, unexpected response: nausea and, to my great surprise, an erection (no figure pro- vided). While I lay in bed with an emesis pan close by, I had an unrelenting erection (about 8 h duration) which could not be subdued even with a cold pack. When my wife came upon the scene, she proclaimed that I “must be crazy.” In response, I raised my arm feebly into the air and answered, “I think we may become rich.” Around 1984, in collaboration with Victor Hruby (Uni- versity of Arizona Chemistry Department) and his students (e.g., Tomi K. Sawyer), we synthesized and biologically char- acterized some superpotent melanotropic peptides [9]. One of these [Nle*, DPhe’]-substituted MCs, referred to as Melano- tan I (MTT), was licensed for commercialization as a tanning agent (Fig. 1). This MC is well on its way toward devel- opment for use as a potential “therapeutic tan,” a “tan from inside-out,” with minimal need for prolonged sun exposure [4]. During the development of MTI, I served as a proverbial “human pincushion” (a k.a., guinea pig), that is, I tested the efficacy of the peptide to produce a tan on myself. Therein lies a very interesting story. Our group of University inves- tigators (Hadley, Hruby and his student Fahad Al-Obeidi) prepared and characterized some fragment [Nle*, DPhe’]- substituted MC analogs that proved to be as potent as MTI, even though structurally only half the size (seven amino acids) of the parent analog [1,2]. In addition, the melan-
January 2, 2026 at 5:07 PM
kidneystories.bsky.social
Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity - goo.gl/alerts/MJuPez #GoogleAlerts
Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity
Objective Pathogenic variants in five established leptin-melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early-onset obesity and are targets for emerging treatme...
goo.gl
December 27, 2025 at 1:15 PM
fogspray.bsky.social
Product Description
Melanotan II (MT-2) is a synthetic melanocortin peptide widely used in in vitro mechanistic research to investigate melanocortin receptor signaling, peptide-receptor interactions, and downstream intracellular pathways. #GMP
arizona-mall.com/product/mela...
Melanotan II (MT-2) high-purity-peptide-factory-wholesale
Melanotan II (MT-II) is a high-purity synthetic peptide designed for in vitro molecular research involving melanocortin receptor signaling, peptide–receptor interactions, and intracellular pathway studies. Factory-manufactured under controlled conditions, MT-II supports mechanistic exploration in receptor selectivity, cAMP-mediated signaling, and peptide structure–activity relationships. Available for bulk, wholesale, and B2B export.
arizona-mall.com
December 24, 2025 at 3:36 PM
fogspray.bsky.social
Product Description
Melanotan I is a synthetic peptide specifically supplied for advanced laboratory-based, in vitro molecular research, with a primary focus on melanocortin receptor signaling and peptide–receptor interaction mechanisms. #GMP
arizona-mall.com/product/mela...
Melanotan I - 99.75%high-purity-peptide-factory-wholesale
Melanotan I is a synthetic analogue of ?-MSH and a potent non-selective melanocortin receptor agonist. With 99.75% purity and GMP-grade production, it is ideal for research into skin pigmentation, melanoma, inflammation, and erectile dysfunction. For laboratory use only.?For wholesale prices, other specifications and uses, please consult our staff?
arizona-mall.com
December 24, 2025 at 2:15 PM
jcellsci.bsky.social
Pragya Parashara, Teresa Gunn, Jennifer Kong @jennkong.bsky.social and colleagues discover that the E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
journals.biologists.com/jcs/article/...
Figure showing that ATRN interacts with the RING domain of MGRN1. AlphaFold-predicted ATRN–MGRN1 and ATRNL1–MGRN1 interactions. Both ATRN (residues 1157–1429, dark pink) and ATRNL1 (residues 1107–1379, light pink) contain four distinct domains, which we refer to as the extracellular stem (Stem), transmembrane (TM), cytoplasmic helix (Helix) and cytoplasmic tail (Tail). In interaction models, MGRN1 (orange) interacts with the cytoplasmic helix and tail of ATRN and ATRNL1. AlphaFold prediction of ATRN and ATRNL1 interacting with the MGRN1 pre-engager (yellow), engager (light orange) and RING (dark orange) domains. (B) Schematic of the domain organization of MGRN1 (533 aa) and the large deletions generated for the interaction assays. (C) Co-IP analysis of the ATRN–MGRN1 interactions in wild-type and Mgrn1−/−; Rnf157−/− NIH/3T3 cells stably expressing FLAG-tagged wild-type Mgrn1 or one of several Mgrn1 truncation mutants. The mutants include deletions of the Pre-engager (ΔPreEngShort and ΔPreEngLong, residues 35–48 and 35–82, respectively), Engager (ΔEng, residues 79–260), RING (ΔRING, residues 260–335) and disordered tail (ΔTail, residues 335-460). The asterisks (*) indicate the endogenous monomeric band of ATRN observed in the Flag IPs that was used for quantification. (D) Quantification of endogenous ATRN western blot signal intensities relative to wild-type and truncated MGRN1 in immunoprecipitated samples. The graph represents data from three independent experiments, with each dot representing one experimental replicate and with horizontal lines denoting the mean±s.d. Statistical significance was determined using one-way ANOVA with multiple comparisons. *P<0.05; **P<0.01; ****P<0.0001; ns, not significant.
December 17, 2025 at 9:41 AM
tessasaurus.bsky.social
These melanosomes may also tell us something about sauropod metabolism! The melanocortin system, which is responsible for many physiological things in your body, including the creation of melanosomes, is affected by metabolism. 20/26
December 10, 2025 at 3:28 PM
d-and-d-world.bsky.social
BREAKING: Dicot Pharma unveils how LIB-01, a new class of ED drug, works. It targets the brain's melanocortin system for a sustained effect, even in non-responders. Phase 2a data shows benefits last 8+ weeks.

#News #EDtreatment #menshealth #clinicaltrial #ErectileDysfunction
Dicot Pharma unlocks sustained ED effect with LIB-01
Swedish company reveals how LIB-01, an erectile dysfunction therapy, works via the melanocortin system, offering sustained effects and possible hope for non-responders.
druganddeviceworld.com
December 8, 2025 at 7:41 PM
phalguniddw.bsky.social
BREAKING: Dicot Pharma unveils how LIB-01, a new class of ED drug, works. It targets the brain's melanocortin system for a sustained effect, even in non-responders. Phase 2a data shows benefits last 8+ weeks.

#News #EDtreatment #menshealth #clinicaltrial #ErectileDysfunction
Dicot Pharma unlocks sustained ED effect with LIB-01
Swedish company reveals how LIB-01, an erectile dysfunction therapy, works via the melanocortin system, offering sustained effects and possible hope for non-responders.
druganddeviceworld.com
December 8, 2025 at 7:41 PM
unmc-id.bsky.social
Congrats to Dr. Sara Bares on her latest publication in @ofidjournal.bsky.social:

"Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy"

#IDSky #HIVSky

pubmed.ncbi.nlm.nih.gov/41322244/
Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy - PubMed
Given the melanocortin-4 receptor's (MC4R) importance in obesity, we examined associations between <i>MC4R</i> gene variants and weight following a switch to integrase inhibitor-containing antiretroviral therapy among participants in Advancing Clinical Therapeutics Globally studies. Among 529 person …
pubmed.ncbi.nlm.nih.gov
December 5, 2025 at 4:48 PM
plosbiology.org
The hypothalamic #melanocortin circuit is crucial for regulating energy balance, but how does it arise? @sebastienbouret.bsky.social &co show in mice that early postnatal activity & vesicle release from #oxytocin neurons are critical for proper circuit development @plosbiology.org 🧪 plos.io/49ifiKW
Micrograph showing genetically labeled oxytocin-producing neurons (green fluorescence) in the paraventricular nucleus of the mouse hypothalamus. Credit: Pierre-Yves Barelle & Sebastien G Bouret.
November 14, 2025 at 8:55 AM
plosbiology.org
The hypothalamic #melanocortin circuit is crucial for regulating energy balance, but how does it arise? @sebastienbouret.bsky.social &co show in mice that early postnatal activity & vesicle release from #oxytocin neurons are critical for proper circuit development @plosbiology.org 🧪 plos.io/49ifiKW
Micrograph showing genetically labeled oxytocin-producing neurons (green fluorescence) in the paraventricular nucleus of the mouse hypothalamus. Credit: Pierre-Yves Barelle & Sebastien G Bouret.
November 13, 2025 at 5:33 PM
plosbiology.org
The hypothalamic #melanocortin circuit is crucial for regulating energy balance, but how does it arise? @sebastienbouret.bsky.social &co show in mice that early postnatal activity & vesicle release from #oxytocin neurons are critical for proper circuit development @plosbiology.org 🧪 plos.io/49ifiKW
November 13, 2025 at 1:52 PM
bsneuroendo.bsky.social
"I could take the money personally but I put it into my research" - Prof White on how she invests money from commercial enterprise.

Watch Anne's full lecture on Melanocortin neuropeptides as a BSN member (login to mySociety):

my.neuroendo.org.uk/...
November 13, 2025 at 11:57 AM
bsneuroendo.bsky.social
Prof Anne White on the challenges of being a woman & non-clinical scientist in clinical research.

For more rewatch Anne's full Mortyn Jones Lecture 'Melanocortin neuropeptides: a story of science and serendipity' as a BSN member (login to mySociety):

my.neuroendo.org.uk/...

November 12, 2025 at 5:21 PM
bsneuroendo.bsky.social
"I could take the money personally but I put it into my research" - Prof White on how she invests money from commercial enterprise.

Watch Anne's full lecture on Melanocortin neuropeptides as a BSN member (login to mySociety):

my.neuroendo.org.uk/...
November 9, 2025 at 7:59 PM