Aussie Suzuki focuses on kinetochore functions in faithful chromosome segregation to study how the loss of kinetochore integrity causes cancer. #WARF100 @uwchancellor.bsky.social @mcardlelab.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_aussiesuzuki/
November 15, 2025 at 9:49 PM
Aussie Suzuki focuses on kinetochore functions in faithful chromosome segregation to study how the loss of kinetochore integrity causes cancer. #WARF100 @uwchancellor.bsky.social @mcardlelab.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_aussiesuzuki/
Alves Domingos, Green, Cheerambathur et al. reveal that the #kinetochore protein KNL-1 regulates the #actin #cytoskeleton to control dendrite branching. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
November 14, 2025 at 4:15 PM
Alves Domingos, Green, Cheerambathur et al. reveal that the #kinetochore protein KNL-1 regulates the #actin #cytoskeleton to control dendrite branching. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
Happening TODAY - Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
November 14, 2025 at 3:00 PM
Happening TODAY - Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organisation across kingdoms, underscoring its deep evolutionary origin.
November 14, 2025 at 6:57 AM
Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organisation across kingdoms, underscoring its deep evolutionary origin.
New publication from Dr. @dipesh-lab.bsky.social in collaboration with Prof. @raphmercier.bsky.social from @mpipz.bsky.social in @commsbio.nature.com Journal on Kinetochore KMN complex.
Read the paper for more: www.nature.com/articles/s42...
#Kinetochore #KMNcomplex #arabidopsis
Read the paper for more: www.nature.com/articles/s42...
#Kinetochore #KMNcomplex #arabidopsis
November 14, 2025 at 6:56 AM
New publication from Dr. @dipesh-lab.bsky.social in collaboration with Prof. @raphmercier.bsky.social from @mpipz.bsky.social in @commsbio.nature.com Journal on Kinetochore KMN complex.
Read the paper for more: www.nature.com/articles/s42...
#Kinetochore #KMNcomplex #arabidopsis
Read the paper for more: www.nature.com/articles/s42...
#Kinetochore #KMNcomplex #arabidopsis
Latest #GENETICS study uses structural analysis to identify components of the #Candida albicans inner kinetochore network and shows their functions in fitness and cell cycle progression by carrying out loss-of-function mutant characterization. buff.ly/Z9QI9aU
November 10, 2025 at 9:02 PM
Latest #GENETICS study uses structural analysis to identify components of the #Candida albicans inner kinetochore network and shows their functions in fitness and cell cycle progression by carrying out loss-of-function mutant characterization. buff.ly/Z9QI9aU
www.nature.com/articles/s42...
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms - Communications Biology
Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organization across k...
www.nature.com
November 7, 2025 at 7:02 PM
www.nature.com/articles/s42...
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
Latest from the lab. The conclusion is in the title!
Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
See you next week for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
November 7, 2025 at 6:00 PM
See you next week for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays www.biorxiv.org/content/10.1101/2025.11.04.686567v1 #cryoem
November 5, 2025 at 8:10 AM
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays www.biorxiv.org/content/10.1101/2025.11.04.686567v1 #cryoem
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays https://www.biorxiv.org/content/10.1101/2025.11.04.686567v1
November 5, 2025 at 4:17 AM
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays https://www.biorxiv.org/content/10.1101/2025.11.04.686567v1
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays https://www.biorxiv.org/content/10.1101/2025.11.04.686567v1
November 5, 2025 at 4:17 AM
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays https://www.biorxiv.org/content/10.1101/2025.11.04.686567v1
These findings highlight the significance of Stu2's kinetochore role and provide insights into the molecular mechanisms underlying its various functions, which are crucial for understanding chromosome segregation and cell division.
November 4, 2025 at 9:55 AM
These findings highlight the significance of Stu2's kinetochore role and provide insights into the molecular mechanisms underlying its various functions, which are crucial for understanding chromosome segregation and cell division.
Secondly, the precise location of Stu2 within the kinetochore is critical for its function, indicating a spatial separation mode of action that allows it to confer tension sensitivity.
November 4, 2025 at 9:55 AM
Secondly, the precise location of Stu2 within the kinetochore is critical for its function, indicating a spatial separation mode of action that allows it to confer tension sensitivity.
Using separation-of-function mutants and artificial tethering tools, the study made several important discoveries. Firstly, Stu2's microtubule polymerization activity is dispensable for viability, suggesting it has an essential kinetochore-associated function.
November 4, 2025 at 9:55 AM
Using separation-of-function mutants and artificial tethering tools, the study made several important discoveries. Firstly, Stu2's microtubule polymerization activity is dispensable for viability, suggesting it has an essential kinetochore-associated function.
Stu2, a key protein, has surprising functions beyond microtubule polymerization - it plays an essential role at the kinetochore, crucial for chromosome segregation and cell survival.
🧵 Thread below
Full analysis: https://helixbrief.com/article/00caa5e7-44d2-4b18-8019-9ce674b1d441
🧵 Thread below
Full analysis: https://helixbrief.com/article/00caa5e7-44d2-4b18-8019-9ce674b1d441
November 4, 2025 at 9:55 AM
Stu2, a key protein, has surprising functions beyond microtubule polymerization - it plays an essential role at the kinetochore, crucial for chromosome segregation and cell survival.
🧵 Thread below
Full analysis: https://helixbrief.com/article/00caa5e7-44d2-4b18-8019-9ce674b1d441
🧵 Thread below
Full analysis: https://helixbrief.com/article/00caa5e7-44d2-4b18-8019-9ce674b1d441
A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation https://www.biorxiv.org/content/10.1101/2025.10.31.685952v1
November 1, 2025 at 5:30 PM
A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation https://www.biorxiv.org/content/10.1101/2025.10.31.685952v1
A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation https://www.biorxiv.org/content/10.1101/2025.10.31.685952v1
November 1, 2025 at 5:30 PM
A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation https://www.biorxiv.org/content/10.1101/2025.10.31.685952v1
Ines Anna Drinnenberg @institutcurie.bsky.social @sorbonne-universite.fr and co-workers @nordicembl.bsky.social show that #insects evolved a conserved monomeric #histone fold domain in the CENP-T #kinetochore protein family. #evolution
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
November 1, 2025 at 9:07 AM
Ines Anna Drinnenberg @institutcurie.bsky.social @sorbonne-universite.fr and co-workers @nordicembl.bsky.social show that #insects evolved a conserved monomeric #histone fold domain in the CENP-T #kinetochore protein family. #evolution
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
Join us for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
October 31, 2025 at 5:00 PM
Join us for Darren Mallett’s dissertation defense!
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
Title: Uncovering the mechanisms that control unattached kinetochore clustering
Lab: Biggins Lab, FH
When: Friday, November 14, 10 a.m. PST
Where: Fred Hutch Pelton Auditorium (Weintraub Building)
We propose a kinetochore-centrosome feedback mechanism controlling chromosome movement: chromosomes near centrosomes rely on CENP-E because high Aurora A activity boosts Aurora B at kinetochores, restricting end-on attachments. CENP-E counteracts this by downregulating Aurora B.
October 29, 2025 at 5:09 PM
We propose a kinetochore-centrosome feedback mechanism controlling chromosome movement: chromosomes near centrosomes rely on CENP-E because high Aurora A activity boosts Aurora B at kinetochores, restricting end-on attachments. CENP-E counteracts this by downregulating Aurora B.
Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
October 27, 2025 at 11:35 AM
Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Great talk by @uendesfelder.bsky.social at #ChemBioPhys2025. She talked about her group's work on single molecule microscopy to study structure and dynamics in biological systems. Exciting insights into kinetochore structure and bacterial injectisome dynamics (T3SS). rupress.org/jcb/article/...
October 23, 2025 at 1:23 PM
Great talk by @uendesfelder.bsky.social at #ChemBioPhys2025. She talked about her group's work on single molecule microscopy to study structure and dynamics in biological systems. Exciting insights into kinetochore structure and bacterial injectisome dynamics (T3SS). rupress.org/jcb/article/...
Their study was published in @embojournal.org
"MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes"
doi.org/10.1038/s443...
"MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes"
doi.org/10.1038/s443...
MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes | The EMBO Journal
imageimageMeiotic errors in oocytes cause egg aneuploidy. This study shows that kinetochores
employ MPS1 kinase to promote timely spindle bipolarization before stable microtubule
attachments in acentr...
doi.org
October 22, 2025 at 6:59 AM
Their study was published in @embojournal.org
"MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes"
doi.org/10.1038/s443...
"MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes"
doi.org/10.1038/s443...
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1
October 21, 2025 at 9:30 PM
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1
October 21, 2025 at 9:30 PM
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1