Zukai Liu
@zukailiu.bsky.social
Washington Research Foundation fellow in Shendure and Hamazaki labs at UW.
PhD from Robson and Cheng labs at JAX.
Gene editing and Stem cell biology.
PhD from Robson and Cheng labs at JAX.
Gene editing and Stem cell biology.
Reposted by Zukai Liu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
go.nature.com
November 11, 2025 at 4:36 PM
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
Reposted by Zukai Liu
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
November 5, 2025 at 3:09 PM
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
Reposted by Zukai Liu
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
November 4, 2025 at 3:10 PM
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
Reposted by Zukai Liu
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Zukai Liu
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
1/n Wondering how transposable elements shape the evolution of cell lineage specification in embryogenesis? Please check this out! We found that human specific LTR2B can be bound by HAND1, transcribed and spliced into neighboring genes, most of which are human specific ExMC marker genes.
Great work from @zukailiu.bsky.social defining the first mesenchymal cells in human development as trophoblast-derived, and adding to the examples of evolutionary co-option of viral sequences contributing to our uniquely ape/human features. #hiPSC #MorPhiC #EvoDevo
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Redirecting
doi.org
April 15, 2025 at 7:01 AM
1/n Wondering how transposable elements shape the evolution of cell lineage specification in embryogenesis? Please check this out! We found that human specific LTR2B can be bound by HAND1, transcribed and spliced into neighboring genes, most of which are human specific ExMC marker genes.
Reposted by Zukai Liu
Great work from @zukailiu.bsky.social defining the first mesenchymal cells in human development as trophoblast-derived, and adding to the examples of evolutionary co-option of viral sequences contributing to our uniquely ape/human features. #hiPSC #MorPhiC #EvoDevo
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Redirecting
doi.org
April 12, 2025 at 2:40 AM
Great work from @zukailiu.bsky.social defining the first mesenchymal cells in human development as trophoblast-derived, and adding to the examples of evolutionary co-option of viral sequences contributing to our uniquely ape/human features. #hiPSC #MorPhiC #EvoDevo
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Reposted by Zukai Liu
Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9
www.biorxiv.org
March 19, 2025 at 3:44 PM
Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9
Reposted by Zukai Liu
I can highly recommend the YEN 2025 meeting for students and postdocs working on 'anything embryo' - a fantastic meeting organized by students and postdocs for you!
Registration open for this year's Young Embryologist Network meeting
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
19 May, The Francis Crick Institute, London
thenode.biologists.com/yen-2025-con...
YEN 2025 Conference: Registration is open! - the Node
Register now for the Young Embryologist Network meeting - Monday 19 May 2025 at the Francis Crick Institute. Are you an early career researcher in
thenode.biologists.com
February 3, 2025 at 6:50 PM
I can highly recommend the YEN 2025 meeting for students and postdocs working on 'anything embryo' - a fantastic meeting organized by students and postdocs for you!
Reposted by Zukai Liu
Brief PSA for the functional genomics community: if you are profiling complex libraries with >1 internal components (e.g., enhancer+barcodes in MPRAs) delivered via AAVs, be aware that there might be substantial unlinking within your libraries if you packaged as a pool! doi.org/10.1101/2025...
January 17, 2025 at 3:53 PM
Brief PSA for the functional genomics community: if you are profiling complex libraries with >1 internal components (e.g., enhancer+barcodes in MPRAs) delivered via AAVs, be aware that there might be substantial unlinking within your libraries if you packaged as a pool! doi.org/10.1101/2025...
Wonderful work! Congrats, Ryan!
My thesis work on active machine learning to model regulatory DNA is now out in Cell Systems!
We answer the question: When you can synthesize any DNA sequence you want, how do you decide which ones are worth testing?
www.sciencedirect.com/science/arti...
We answer the question: When you can synthesize any DNA sequence you want, how do you decide which ones are worth testing?
www.sciencedirect.com/science/arti...
January 8, 2025 at 9:01 AM
Wonderful work! Congrats, Ryan!