Zukai Liu
@zukailiu.bsky.social
Washington Research Foundation fellow in Shendure and Hamazaki labs at UW.
PhD from Robson and Cheng labs at JAX.
Gene editing and Stem cell biology.
PhD from Robson and Cheng labs at JAX.
Gene editing and Stem cell biology.
Thank you for pointing this out! Absolutely amazing work on the mouse HAP gastruloids! We updated our preprint here www.biorxiv.org/content/10.1...
Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning
Human gastruloids are a powerful class of stem cell derived models that recapitulate key features of early embryonic development, including symmetry breaking and the emergence of three germ layers. Ho...
www.biorxiv.org
September 27, 2025 at 4:01 AM
Thank you for pointing this out! Absolutely amazing work on the mouse HAP gastruloids! We updated our preprint here www.biorxiv.org/content/10.1...
4/n This is absolutely a teamwork and it would not be done without the support from Robson Lab and Cell Engineering Lab at JAX. My deepest gratitude goes to my mentor @paulrobson.bsky.social for his amazing guidance, support and encouragement along this journey!
April 15, 2025 at 7:24 AM
4/n This is absolutely a teamwork and it would not be done without the support from Robson Lab and Cell Engineering Lab at JAX. My deepest gratitude goes to my mentor @paulrobson.bsky.social for his amazing guidance, support and encouragement along this journey!
3/n As an example of EvoDevo, the ExMC only shows up in peri implementation embryos in apes not in other mammals, making it difficult to be studied. Our hiPSC-based model not only uncovered the molecular basis of this species difference, but provide a powerful tool to study human ExMC.
April 15, 2025 at 7:18 AM
3/n As an example of EvoDevo, the ExMC only shows up in peri implementation embryos in apes not in other mammals, making it difficult to be studied. Our hiPSC-based model not only uncovered the molecular basis of this species difference, but provide a powerful tool to study human ExMC.
2/n as a young TE, LTR2B was evolved 40 million years ago with around 300 copies across human genome. Then we precisely deleted a single copy of LTB2B and found it is sufficient to down regulate the expression of ANKS1A, a key marker of human ExMC and thus impair the cell specification.
April 15, 2025 at 7:08 AM
2/n as a young TE, LTR2B was evolved 40 million years ago with around 300 copies across human genome. Then we precisely deleted a single copy of LTB2B and found it is sufficient to down regulate the expression of ANKS1A, a key marker of human ExMC and thus impair the cell specification.