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zech-lab.bsky.social
ZechLab
@zech-lab.bsky.social
800 followers 1.7K following 8 posts
Cell Invasion | Mechanobiology | Cytoskeleton | Actin in Ageing | Endolysosomal System | Microscopy @Uni of Liverpool
https://tzech6.wixsite.com/zechlab
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zech-lab.bsky.social
An exciting project to understand cellular ageing in health and disease. Deadline for applications is 4th Dec. Pis don't hesitate to contact us if interested. https://www.findaphd.com/phds/project/mrc-dimen- doctoral-training-partnership-stopping-premature-ageing: investigating-the-role-of-actomyosin-mediated-nuclear- force-feedback-in-cell-homeostasis/?p189509 Please also see our websites for research interests: Tobias Zech: https://tzech6.wixsite.com/zechlab • Chris Toseland: https://www.toseland- lab.com
November 19, 2025 at 12:13 PM
Reposted by ZechLab
livunicancer.bsky.social
Are you interested in studying in the UK for your Masters?

Please join our program director for the MSc Cancer Biology and Therapy at the University of Liverpool for an on-line event.

19th November at 5pm (GMT).

To sign up please use the link below:

lnkd.in/efsXw-ke
November 9, 2025 at 6:25 PM
Reposted by ZechLab
livunicancer.bsky.social
The first to be shared is this one: lnkd.in/euACxRhz

With Marisa Merino, co-supervisers Prof. Hilary Ashe & Prof. Harish Poptani.:

Interested in How Organisms Cope with Growth in Challenging Environments? Open to international applicants.

#DevBio #Microscopy #CellBio #PhDPositions #Genetics
November 12, 2025 at 2:03 PM
Reposted by ZechLab
livunicancer.bsky.social
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social

An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...

#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
www.findaphd.com
November 13, 2025 at 10:25 AM
Reposted by ZechLab
joachimgoedhart.bsky.social
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
(C) Recruitment of the WT PIKfyve-CCR-Kina to Rab5 endosomes and changes in biosensor localization at these membranes is shown by the fluorescence intensity ratios of the constructs at Rab5 endosomes over the whole cell. Data shown is the grand mean ± SEM of 3 experiments. A total of 35 cells were analyzed. Confocal images over time are shown to the right. (D) As in C, but now utilizing the catalytically dead K1876E/V1883I mutant of the FKBP-PIKfyve-CCR-Kina as a negative control.
November 12, 2025 at 6:57 PM
Reposted by ZechLab
bengoult.bsky.social
🧠 Fully funded 4-year PhD studentship 🧠 Please repost

BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social

Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.

www.findaphd.com/phds/project...
(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com
PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com
www.findaphd.com
November 11, 2025 at 10:29 AM
Reposted by ZechLab
bengoult.bsky.social
The project is now live on FindaPhD and open for applications. Deadline December 4th
October 31, 2025 at 10:07 AM
Reposted by ZechLab
bengoult.bsky.social
Vinculin is a simple adapter protein right? Wrong!

That’s been the prevailing view for the 46 years since it was discovered.

Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.

www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Reposted by ZechLab
christoseland.bsky.social
Please repost - Multiple PhDs available

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...

www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Reposted by ZechLab
christoseland.bsky.social
Please Repost!

Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!

www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis at University of Liverpool, l...
www.findaphd.com
November 2, 2025 at 11:13 AM
Reposted by ZechLab
guijacquemet.bsky.social
Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030

abo.rekrytointi.com/paikat/index...
University Researcher in Bioimaging / Universitetsforskare med inriktning bioimaging, 1.11.2025-31.12.2030
abo.rekrytointi.com
September 10, 2025 at 11:28 AM
Reposted by ZechLab
bengoult.bsky.social
Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...
August 28, 2025 at 10:25 AM
Reposted by ZechLab
tanosbarbara.bsky.social
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!

@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
August 18, 2025 at 3:31 PM
Reposted by ZechLab
lsajournal.org
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social
www.life-science-alliance.org/content/8/10...
August 18, 2025 at 3:15 PM
zech-lab.bsky.social
tanosbarbara.bsky.social Barbara Tanos @tanosbarbara.bsky.social · Aug 18
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion.
This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends!

@zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
August 19, 2025 at 9:38 PM
Reposted by ZechLab
cci-liv.bsky.social
Keen about High Performance Computing & #imageanalysis? Search for #75 at #ELMI2025 this evening @sebastianmunck.bsky.social‬ @makaefer.bsky.social
June 5, 2025 at 7:03 AM
Reposted by ZechLab
susanagodinho.bsky.social
👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
👉 deadline 20/06
👇 check it out

www.godinholab.com
June 3, 2025 at 8:57 AM
Reposted by ZechLab
cci-liv.bsky.social
The @livunihls.bsky.social has published their strategy 2025-2031. We cannot get past the cover page though: stunning image taken by our very own image analyst @makaefer.bsky.social before she became the image analyst. @livuni-livsrf.bsky.social @bwilm.bsky.social @raphavisses.bsky.social
Cover page of the University of Liverpool, Faculty of Health and Life Sciences Strategy 2025-2031 document. The page is black and features a multi-channel microscope image of a mouse embryonic kidney stained for ureteric bud (cyan & yellow) and lumen (magenta). The kidney is surrounded by yellow spots which served as fiduciary markers during lightsheet imaging and give the impression of a starry sky.
May 19, 2025 at 12:32 PM
Reposted by ZechLab
jcellsci.bsky.social
Gustavo Pacheco, Douglas DeSimone and colleagues discover that mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signalling in leader row cells.

journals.biologists.com/jcs/article/...

#JCSMitoSI #Mitochondria
Figure showing that MMP in mesendoderm cells is dependent on integrin activation state and signalling.
May 15, 2025 at 9:58 AM
Reposted by ZechLab
scholpplab.bsky.social
Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! 🐠 Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...
May 7, 2025 at 9:20 AM
Reposted by ZechLab
shaneherbert.bsky.social
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
Reposted by ZechLab
jcellsci.bsky.social
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
March 28, 2025 at 11:46 AM
Reposted by ZechLab
pcusachs.bsky.social
Interested in how cells respond when squeezed? Check the review paper just published by Laura Faure, @valeriaventurini.bsky.social and myself on this. Really thorough and clear revision by Laura and Valeria!
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · Mar 28
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
April 1, 2025 at 3:52 PM
Reposted by ZechLab
the-node.bsky.social
It's the last day of #biologists100! We'll be sharing more photos of people posing with our polaroid frame.

Aymen al-Rawi @aymen-alrawi.bsky.social is the @bscb-official.bsky.social postdoc rep and organised the #ECR session at Biologists @ 100. His key words are #CircadianRhythm #MassSpec #MRC_LMB
Aymen al-Rawi posing with the Node's polaroid frame. The text on the frame reads "#ECR #CircadianRhythm #MassSpec #MRC_LMB"
March 27, 2025 at 10:20 AM
Reposted by ZechLab
focalplane.bsky.social
If you are attending #biologists100, you can now visit our image gallery with @the-node.bsky.social in the exhibition hall and vote for your favourite image.
If you are not at the conference, you can still vote in our poll on FocalPlane: focalplane.biologists.com/2025/03/11/v...
Picture of easels displaying microscopy images.
March 25, 2025 at 10:28 AM