Xavier
@xaviervel.bsky.social
Nephrologist at the UMass Chan School of Medicine.
Reposted by Xavier
Is coprescription of gabapentinoids with other psychoactive medications associated with altered mental status and falls? #nephrology #dialysis #gabapentinoid #psychoactivemedication
Altered Mental Status and Falls When Gabapentinoid and Other Psychoactive Medications Are Coprescrib | Docwire News
A study assessed the association of coprescribing gabapentinoids and other psychoactive medications with altered mental status and falls in kidney disease.
www.docwirenews.com
April 21, 2025 at 6:52 PM
Is coprescription of gabapentinoids with other psychoactive medications associated with altered mental status and falls? #nephrology #dialysis #gabapentinoid #psychoactivemedication
Reposted by Xavier
Reversible glomerular thrombotic microangiopathy associated with nintedanib in a kidney transplant recipient
#nephsky
www.kireports.org/article/S246...
#nephsky
www.kireports.org/article/S246...
Reversible glomerular thrombotic microangiopathy associated with nintedanib in a kidney transplant recipient
We present the case of a 69-year-old male patient non sensitized against HLA who underwent
a first kidney transplant after diabetic nephropathy. The patient was also diagnosed
with idiopathic pulmonar...
www.kireports.org
April 12, 2025 at 8:07 AM
Reversible glomerular thrombotic microangiopathy associated with nintedanib in a kidney transplant recipient
#nephsky
www.kireports.org/article/S246...
#nephsky
www.kireports.org/article/S246...
Reposted by Xavier
Paxlovid in advanced CKD, matched study with VA data in @ajkd.bsky.social
www.ajkd.org/article/S027...
cc @christosargyrop.bsky.social - validates our approach 😎
#COVID #NephSky
www.ajkd.org/article/S027...
cc @christosargyrop.bsky.social - validates our approach 😎
#COVID #NephSky
Safety and Effectiveness of Nirmatrelvir-Ritonavir in Patients With Advanced Kidney Dysfunction and COVID-19
Nirmatrelvir-ritonavir prevents COVID-19 hospitalization among high-risk adults, but
safety concerns limit its use in advanced kidney dysfunction. This study examined
safety and effectiveness outcomes...
www.ajkd.org
April 12, 2025 at 3:22 PM
Paxlovid in advanced CKD, matched study with VA data in @ajkd.bsky.social
www.ajkd.org/article/S027...
cc @christosargyrop.bsky.social - validates our approach 😎
#COVID #NephSky
www.ajkd.org/article/S027...
cc @christosargyrop.bsky.social - validates our approach 😎
#COVID #NephSky
Reposted by Xavier
📣Calling early career scientists, trainees, and junior faculty!
The ASN Journal Portfolio’s Junior Associate Editor Program is your chance to dive into editorial work with JASN, CJASN, and Kidney360. Review manuscripts, get mentored, sharpen your skills, and gain recognition.
🔗 bit.ly/3DZJ75B
The ASN Journal Portfolio’s Junior Associate Editor Program is your chance to dive into editorial work with JASN, CJASN, and Kidney360. Review manuscripts, get mentored, sharpen your skills, and gain recognition.
🔗 bit.ly/3DZJ75B
March 27, 2025 at 8:25 PM
📣Calling early career scientists, trainees, and junior faculty!
The ASN Journal Portfolio’s Junior Associate Editor Program is your chance to dive into editorial work with JASN, CJASN, and Kidney360. Review manuscripts, get mentored, sharpen your skills, and gain recognition.
🔗 bit.ly/3DZJ75B
The ASN Journal Portfolio’s Junior Associate Editor Program is your chance to dive into editorial work with JASN, CJASN, and Kidney360. Review manuscripts, get mentored, sharpen your skills, and gain recognition.
🔗 bit.ly/3DZJ75B
Reposted by Xavier
Chloride depletion alkalosis (as opposed to what was previously called 'contraction alkalosis') #Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/
👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/
March 24, 2025 at 1:09 AM
Chloride depletion alkalosis (as opposed to what was previously called 'contraction alkalosis') #Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/
👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/
Reposted by Xavier
I am "CONVINCE"D that #hemodiafiltration will overcome #incrementalhemodialysis in the @nephmadness.bsky.social match on the first round. you will be lost if you chose #incrementalHD #trashtalk #nephmadness or may be the #blueribbonfail are not yet "CONVINVE"D !!
March 22, 2025 at 9:22 AM
I am "CONVINCE"D that #hemodiafiltration will overcome #incrementalhemodialysis in the @nephmadness.bsky.social match on the first round. you will be lost if you chose #incrementalHD #trashtalk #nephmadness or may be the #blueribbonfail are not yet "CONVINVE"D !!
Reposted by Xavier
So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything!
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
March 19, 2025 at 11:22 AM
So @danfuster.bsky.social and colleagues seem to find HCTZ doesn’t work for anything!
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
In a post hoc analysis of NOSTONE (where CT scans were done in all & repurposed for calculating bone density) HCTZ doesn’t increase it vs placebo
journals.lww.com/cjasn/pages/... in @asnpublications.bsky.social
Reposted by Xavier
The @isn-india.bsky.social Journal Club TODAY‼️
📅 When: 19 March 2025 | 08:00 – 09:00 PM IST
📌 Topic: ISN Journal Club – March 2025 - Obinutuzumab in Lupus Nephritis
🔗 Join here: us02web.zoom.us/j/8949743288...
🔑 Passcode: 647870
We look forward to your enthusiastic participation and engagement!
📅 When: 19 March 2025 | 08:00 – 09:00 PM IST
📌 Topic: ISN Journal Club – March 2025 - Obinutuzumab in Lupus Nephritis
🔗 Join here: us02web.zoom.us/j/8949743288...
🔑 Passcode: 647870
We look forward to your enthusiastic participation and engagement!
March 19, 2025 at 12:46 PM
The @isn-india.bsky.social Journal Club TODAY‼️
📅 When: 19 March 2025 | 08:00 – 09:00 PM IST
📌 Topic: ISN Journal Club – March 2025 - Obinutuzumab in Lupus Nephritis
🔗 Join here: us02web.zoom.us/j/8949743288...
🔑 Passcode: 647870
We look forward to your enthusiastic participation and engagement!
📅 When: 19 March 2025 | 08:00 – 09:00 PM IST
📌 Topic: ISN Journal Club – March 2025 - Obinutuzumab in Lupus Nephritis
🔗 Join here: us02web.zoom.us/j/8949743288...
🔑 Passcode: 647870
We look forward to your enthusiastic participation and engagement!
Kidney immunology, not for the faint hearted.
March 13, 2025 at 3:57 AM
Kidney immunology, not for the faint hearted.
Rapid review of lupus nephritis pathogenesis with the fellows today.
March 5, 2025 at 9:32 PM
Rapid review of lupus nephritis pathogenesis with the fellows today.
Reposted by Xavier
It turns out, that under the right conditions, carbonyl groups form on MPO. Hydralazine actually ATTACHES to these carbonyl groups, probably modifying the MPO conformation and inducing a neo-antigen, which eventually causes the formation of anti-MPO IgM!
March 4, 2025 at 9:19 PM
It turns out, that under the right conditions, carbonyl groups form on MPO. Hydralazine actually ATTACHES to these carbonyl groups, probably modifying the MPO conformation and inducing a neo-antigen, which eventually causes the formation of anti-MPO IgM!
Reposted by Xavier
COL4A5 Intronic Variants at Third to Fifth Nucleotides Cause Alport Syndrome pubmed.ncbi.nlm.nih.gov/39990911/
March 3, 2025 at 5:42 PM
COL4A5 Intronic Variants at Third to Fifth Nucleotides Cause Alport Syndrome pubmed.ncbi.nlm.nih.gov/39990911/
Reposted by Xavier
Reposted by Xavier
ACE inhibitors are not nephrotoxic - but 🐍 snakebite from Bothrops spp can cause AKI in kids
link.springer.com/article/10.1...
In @ped-neph.bsky.social
Though it seems not always mediated by hypotension
#NephSky
link.springer.com/article/10.1...
In @ped-neph.bsky.social
Though it seems not always mediated by hypotension
#NephSky
Acute kidney injury induced by snakebites in pediatric patients - Pediatric Nephrology
Background Snakebites are a significant public health problem worldwide, with a global prevalence estimated 2.7 million envenomings and 81,000 to 138,000 deaths annually. Acute kidney injury (AKI) is ...
link.springer.com
February 28, 2025 at 4:43 PM
ACE inhibitors are not nephrotoxic - but 🐍 snakebite from Bothrops spp can cause AKI in kids
link.springer.com/article/10.1...
In @ped-neph.bsky.social
Though it seems not always mediated by hypotension
#NephSky
link.springer.com/article/10.1...
In @ped-neph.bsky.social
Though it seems not always mediated by hypotension
#NephSky
Reposted by Xavier
Most SEs from steroids are longer term and cumulative, aside from infection. I don’t know of many folks that would rx a CNI first.
March 1, 2025 at 2:38 AM
Most SEs from steroids are longer term and cumulative, aside from infection. I don’t know of many folks that would rx a CNI first.
Reposted by Xavier
Steroid if it’s their first or second go, if frequently relapsing go next to CNI, then if breaking through CNI and prednisone it’s RTX
March 1, 2025 at 2:22 AM
Steroid if it’s their first or second go, if frequently relapsing go next to CNI, then if breaking through CNI and prednisone it’s RTX
Reposted by Xavier
Beautiful cover art on the latest issue of @ndt-era.bsky.social @hjanders.bsky.social
From @nephgirlsketch.bsky.social of course!
academic.oup.com/ndt/issue
From @nephgirlsketch.bsky.social of course!
academic.oup.com/ndt/issue
March 1, 2025 at 1:29 AM
Beautiful cover art on the latest issue of @ndt-era.bsky.social @hjanders.bsky.social
From @nephgirlsketch.bsky.social of course!
academic.oup.com/ndt/issue
From @nephgirlsketch.bsky.social of course!
academic.oup.com/ndt/issue
For minimal change disease in adults. Do you always go for steroid as first line? Or do you consider other alternatives (MMF, CNI)? And if so, what are those scenarios? #askRenal
February 28, 2025 at 11:56 PM
For minimal change disease in adults. Do you always go for steroid as first line? Or do you consider other alternatives (MMF, CNI)? And if so, what are those scenarios? #askRenal
Reposted by Xavier
This one goes out to all my fans
February 21, 2025 at 3:22 AM
This one goes out to all my fans
When AIN recurs after a run with steroids. Do people go for MMF? Do you see any positive results with this?
February 20, 2025 at 3:32 AM
When AIN recurs after a run with steroids. Do people go for MMF? Do you see any positive results with this?
Reposted by Xavier
Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis
#nephsky
www.sciencedirect.com/science/arti...
#nephsky
www.sciencedirect.com/science/arti...
Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis
Clinical data and animal models have provided compelling evidence supporting the pathogenic role of complement activation in the progression of focal …
www.sciencedirect.com
February 20, 2025 at 1:59 AM
Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis
#nephsky
www.sciencedirect.com/science/arti...
#nephsky
www.sciencedirect.com/science/arti...
Reposted by Xavier
Good on @kidney.org NKF on putting out a clear statement on this issue
www.kidney.org/press-room/n...
#NephSky
www.kidney.org/press-room/n...
#NephSky
NKF Statement on Mass Staff Terminations at HHS
www.kidney.org
February 19, 2025 at 3:50 AM
Good on @kidney.org NKF on putting out a clear statement on this issue
www.kidney.org/press-room/n...
#NephSky
www.kidney.org/press-room/n...
#NephSky
Clearing my driveway
February 20, 2025 at 3:29 AM
Clearing my driveway