Jacob Wolfe
@wolfepackscience.bsky.social
Passionate About Peptide Chemistry, Enzyme Structure/Design, and Accessible Science 🧪
Nice Jewish Boy ✡️
Pitt Biophysics PhD Candidate - Anticipated Graduation August 2025 🎓
2023-2024 Mellon Predoctoral Fellow in Seth Horne's Lab 👨🔬
Nice Jewish Boy ✡️
Pitt Biophysics PhD Candidate - Anticipated Graduation August 2025 🎓
2023-2024 Mellon Predoctoral Fellow in Seth Horne's Lab 👨🔬
Excited to present a flash talk and poster at the APS 2025 Conference!
🎤Flash Talk Info
📅 Date: Sunday, June 15, 2025
⏰ Time: 1:00 PM - 3:45 PM PST (Exact 10 min Slot, TBA)
🖼️ Poster Number P-047, Poster Session 1
📅 Date: Monday, June 16, 2025
⏰ Time: 12:30 PM - 2:00 PM PST
#ChemSky #PCJC
🎤Flash Talk Info
📅 Date: Sunday, June 15, 2025
⏰ Time: 1:00 PM - 3:45 PM PST (Exact 10 min Slot, TBA)
🖼️ Poster Number P-047, Poster Session 1
📅 Date: Monday, June 16, 2025
⏰ Time: 12:30 PM - 2:00 PM PST
#ChemSky #PCJC
June 3, 2025 at 7:34 PM
Reposted by Jacob Wolfe
We're excited to share our latest paper, just accepted in ACS Catalysis! 🎉 in which we describe how positionally addressable peptide libraries (SPOT libraries) can be used to discover artificial metallopeptide catalysts that work inside living cells. 👇 #ChemSky
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Streamlined Identification of Metallopeptides for Intracellular Catalysis Using Positionally Addressable Combinatorial Libraries
The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface of Chemistry and Biology. Current approaches rely on time-...
pubs.acs.org
May 8, 2025 at 8:29 AM
We're excited to share our latest paper, just accepted in ACS Catalysis! 🎉 in which we describe how positionally addressable peptide libraries (SPOT libraries) can be used to discover artificial metallopeptide catalysts that work inside living cells. 👇 #ChemSky
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
#ChemSky #PCJC #Peptide #AcademicSky #BioSky
Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature
Link to Article - www.linkedin.com/pulse/202504...
Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature
Link to Article - www.linkedin.com/pulse/202504...
April 14, 2025 at 9:24 PM
#ChemSky #PCJC #Peptide #AcademicSky #BioSky
Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature
Link to Article - www.linkedin.com/pulse/202504...
Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature
Link to Article - www.linkedin.com/pulse/202504...
I have been writing a series of LinkedIn articles summarizing #AlphaFold 3 best practices. Hopefully they're a good resource for everyone on here too.
Link to New Article- www.linkedin.com/pulse/alphaf...
#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry
Link to New Article- www.linkedin.com/pulse/alphaf...
#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry
March 24, 2025 at 5:24 PM
I have been writing a series of LinkedIn articles summarizing #AlphaFold 3 best practices. Hopefully they're a good resource for everyone on here too.
Link to New Article- www.linkedin.com/pulse/alphaf...
#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry
Link to New Article- www.linkedin.com/pulse/alphaf...
#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry
Really feels like De Novo Miniprotein bunders are the future of peptide therapeutics #BioSky #MedSky #ChemSky
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors [new]
Computational methods design miniproteins binding to GPCRs. Agonists & antagonists were created and validated structurally.
Computational methods design miniproteins binding to GPCRs. Agonists & antagonists were created and validated structurally.
March 24, 2025 at 3:32 AM
Reposted by Jacob Wolfe
👁️💧 NEW RESEARCH!
Kernardo- Colón et al. prevent vision loss in mice and human retinal cells using the small peptide H105A in eye drops to promote photoreceptor survival in the eye.
#Medsky #academicsky 🩺⚕️👀
Read more here: www.nature.com/articles/s43...
Kernardo- Colón et al. prevent vision loss in mice and human retinal cells using the small peptide H105A in eye drops to promote photoreceptor survival in the eye.
#Medsky #academicsky 🩺⚕️👀
Read more here: www.nature.com/articles/s43...
H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration - Communications Medicine
Bernardo-Colón et al. evaluate small peptides derived from the neurotrophic region of pigment epithelium-derived factor (PEDF) as potential therapeutics for retinitis pigmentosa using mouse models and...
www.nature.com
March 21, 2025 at 1:57 PM
👁️💧 NEW RESEARCH!
Kernardo- Colón et al. prevent vision loss in mice and human retinal cells using the small peptide H105A in eye drops to promote photoreceptor survival in the eye.
#Medsky #academicsky 🩺⚕️👀
Read more here: www.nature.com/articles/s43...
Kernardo- Colón et al. prevent vision loss in mice and human retinal cells using the small peptide H105A in eye drops to promote photoreceptor survival in the eye.
#Medsky #academicsky 🩺⚕️👀
Read more here: www.nature.com/articles/s43...
Green chemistry doesn't get the love it deserves. With more peptide drugs being developed every day, it's great to see researchers working to make that process more sustainable!
#ChemSky #BioSky
#ChemSky #BioSky
Addressing sustainability challenges in peptide synthesis
with flow chemistry and machine learning
Authors: Kristóf Ferentzi, Viktor Farkas, András Perczel
DOI: 10.26434/chemrxiv-2025-93c25
with flow chemistry and machine learning
Authors: Kristóf Ferentzi, Viktor Farkas, András Perczel
DOI: 10.26434/chemrxiv-2025-93c25
March 18, 2025 at 1:46 PM
Miniproteins are a potential therapeutic modality, and multimeric mini-proteins are a clever way to obtain a high degree of structural complexity with only 30-60 amino acids. Always exciting to expand the toolkit of amino acids available to increase their thermodynamic stability! #ChemSky #BioSky
Just out: Stabilization of a miniprotein fold by an unpuckered proline surrogate
Stabilization of a miniprotein fold by an unpuckered proline surrogate
Communications Chemistry, Published online: 12 March 2025; doi:10.1038/s42004-025-01474-6Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is…
bit.ly
March 12, 2025 at 6:38 PM
Reposted by Jacob Wolfe
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry
This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.
jamanetwork.com
March 10, 2025 at 2:15 PM
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
The new HHS Secretary -in charge of nearly every major biomedical research funding agency in the US- was finalized today.
If you want to know how your Senators voted and adjust your vote accordingly, you can get that information here.
#NIH #CDC #NSF #AcademicSky #ChemSky
If you want to know how your Senators voted and adjust your vote accordingly, you can get that information here.
#NIH #CDC #NSF #AcademicSky #ChemSky
How the Senate Voted to Confirm R.F.K. Jr. as Health Secretary
The Senate confirmed Mr. Kennedy by a vote of 52 to 48 to lead the department responsible for public health.
www.nytimes.com
February 14, 2025 at 3:39 AM
The new HHS Secretary -in charge of nearly every major biomedical research funding agency in the US- was finalized today.
If you want to know how your Senators voted and adjust your vote accordingly, you can get that information here.
#NIH #CDC #NSF #AcademicSky #ChemSky
If you want to know how your Senators voted and adjust your vote accordingly, you can get that information here.
#NIH #CDC #NSF #AcademicSky #ChemSky
Reposted by Jacob Wolfe
Many #researchintegrity sleuths are volunteers with little financial support for their often-daunting work to uncover #scientificfraud. One of the most prominent, Elisabeth Bik, has now provided money to change that. @elisabethbik.bsky.social @science.org www.science.org/content/arti...
Renowned scientific integrity investigator endows fund to support fellow sleuths
Microbiologist Elisabeth Bik donates $200,000 to support training, travel
www.science.org
February 13, 2025 at 5:08 PM
Many #researchintegrity sleuths are volunteers with little financial support for their often-daunting work to uncover #scientificfraud. One of the most prominent, Elisabeth Bik, has now provided money to change that. @elisabethbik.bsky.social @science.org www.science.org/content/arti...
Reposted by Jacob Wolfe
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
#LawSky #AcademicSky Grad student here, can someone explain to me like I'm 5 years old how a researcher would pursue legal action for the illegal impoundment of funds allocated to them by congress?
Most R01 schools have good lawyers, but making the info public right now would be good
Most R01 schools have good lawyers, but making the info public right now would be good
Background on Unlawful Impoundment in President Trump’s Executive Orders
Impoundment—unilateral action taken by the executive branch to delay or cancel appropriations enacted into law—has always been unlawful.
democrats-appropriations.house.gov
February 8, 2025 at 2:49 PM
#LawSky #AcademicSky Grad student here, can someone explain to me like I'm 5 years old how a researcher would pursue legal action for the illegal impoundment of funds allocated to them by congress?
Most R01 schools have good lawyers, but making the info public right now would be good
Most R01 schools have good lawyers, but making the info public right now would be good
Reposted by Jacob Wolfe
The latest from your government, brought to you by @science.org.bsky.social NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...
NIH slashes overhead payments for research, sparking outrage
Move to cut indirect cost rate to 15% could cost universities billions of dollars
www.science.org
February 8, 2025 at 1:21 PM
The latest from your government, brought to you by @science.org.bsky.social NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...
Reposted by Jacob Wolfe
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
What's Happening Inside the NIH and NSF
www.science.org
February 4, 2025 at 4:40 PM
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Jacob Wolfe
Happy Black History Month! I’m trying to compile a list of contemporary black chemists and I could only think of 20 off the top of my head. Drop some names please. Thank you!
February 2, 2025 at 3:48 PM
Happy Black History Month! I’m trying to compile a list of contemporary black chemists and I could only think of 20 off the top of my head. Drop some names please. Thank you!
Reposted by Jacob Wolfe
PNAS is committed to advancing global scientific equity.
We provide free access to journal content dating back to 1915 and waive publication fees for researchers in over 120 lower-income countries, removing barriers to knowledge and discovery. Learn more: www.pnas.org/post/update/...
We provide free access to journal content dating back to 1915 and waive publication fees for researchers in over 120 lower-income countries, removing barriers to knowledge and discovery. Learn more: www.pnas.org/post/update/...
January 31, 2025 at 8:23 PM
PNAS is committed to advancing global scientific equity.
We provide free access to journal content dating back to 1915 and waive publication fees for researchers in over 120 lower-income countries, removing barriers to knowledge and discovery. Learn more: www.pnas.org/post/update/...
We provide free access to journal content dating back to 1915 and waive publication fees for researchers in over 120 lower-income countries, removing barriers to knowledge and discovery. Learn more: www.pnas.org/post/update/...