Jacob Wolfe
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wolfepackscience.bsky.social
Jacob Wolfe
@wolfepackscience.bsky.social
67 followers 160 following 18 posts
Passionate About Peptide Chemistry, Enzyme Structure/Design, and Accessible Science 🧪

Nice Jewish Boy ✡️

Pitt Biophysics PhD Candidate - Anticipated Graduation August 2025 🎓

2023-2024 Mellon Predoctoral Fellow in Seth Horne's Lab 👨‍🔬
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wolfepackscience.bsky.social
Excited to present a flash talk and poster at the APS 2025 Conference!

🎤Flash Talk Info
📅 Date: Sunday, June 15, 2025
⏰ Time: 1:00 PM - 3:45 PM PST (Exact 10 min Slot, TBA)

🖼️ Poster Number P-047, Poster Session 1
📅 Date: Monday, June 16, 2025
⏰ Time: 12:30 PM - 2:00 PM PST

#ChemSky #PCJC
June 3, 2025 at 7:34 PM
wolfepackscience.bsky.social
#ChemSky #PCJC #Peptide #AcademicSky #BioSky

Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature

Link to Article - www.linkedin.com/pulse/202504...
April 14, 2025 at 9:24 PM
wolfepackscience.bsky.social
I have been writing a series of LinkedIn articles summarizing #AlphaFold 3 best practices. Hopefully they're a good resource for everyone on here too.

Link to New Article- www.linkedin.com/pulse/alphaf...

#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry
LinkedIn Article Title: Alpha Fold 3 Best Practices - How to Confidently Present an AF3 Structure (With Code!) The image is a two panel, on the left is a bar graph displaying triplicate mean and standard deviation values from 3 independent AlphaFold refolding simulations for the protein GB1, it's reversed sequence, and a scrambled sequence. On the right shows 4 ChimeraX visualizations of the models from that analysis. The original crystal structure 1PGA is color coded grey, other 3 models (GB1, Reversed, and Scramble) are color coded by Ca pLDDT scores. The reversed and scramble sequences have much lower scores.
March 24, 2025 at 5:24 PM