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commsmed.nature.com
Communications Medicine
@commsmed.nature.com
A selective open access journal from @NaturePortfolio publishing research, reviews & commentary across clinical, translational & public health research fields. nature.com/commsmed
🚨 NEW RESEARCH! ⚕️ 🩺

Grieger, Takele, Vesco et al. perform a systematic review and meta-analysis on the individualized effectiveness of lifestyle interventions and weight gain during pregnancy.

https://bit.ly/481mCrX
#PregnancyHealth
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis - Communications Medicine
Grieger, Takele, Vesco, et al. perform a systematic review and meta-analysis of gestational weight gain interventions. Findings indicate lifestyle interventions that reduce excessive gestational weight gain provide greater benefits for women with a normal BMI and higher HDL cholesterol levels at the initiation of interventions.
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November 14, 2025 at 1:01 PM
Reposted by Communications Medicine
This year marks the 30th anniversary of the Healthy Islands vision. @natcomms.nature.com has launched a new collection seeking manuscripts on Pacific Islander health in collaboration with @commsmed.nature.com and Scientific Reports. Please consider submitting your work to us!
November 12, 2025 at 7:40 PM
Reposted by Communications Medicine
Calling all researchers! Submit your life course epi manuscripts to a collaborative collection with @natcomms.nature.com, @commsmed.nature.com and Scientific Reports
November 12, 2025 at 7:37 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Harre et al. find that cholesterol drives tumor progression and immune suppression in non-small lung cancer while omega-3 PUFAs reduce tumor burden.

https://bit.ly/3LY7nIQ
#CancerResearch
Dietary ω−3 polyunsaturated fatty acids (PUFAs) reduce cholesterol-driven non-small cell lung cancer (NSCLC) progression in mouse models of disease - Communications Medicine
Harre et al. analyze serum lipids from patients with NSCLC and test how cholesterol- or ω−3 PUFA–enriched diets affect tumor growth and immunity in mouse models, with or without PD-1 therapy. They find that cholesterol drives tumor progression and immune suppression, while ω−3 PUFAs reduce tumor burden and improve PD-1 efficacy
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November 13, 2025 at 1:46 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Hsu et al. find that angiotensin receptor-neprilysin inhibitors (ARNIs) in individuals with CPOD and heart failure may reduce COPD symptoms.

https://bit.ly/3JFsbUV
#RespiratoryHealth
Angiotensin receptor-neprilysin inhibitor treatment in people with chronic obstructive pulmonary disease and heart failure - Communications Medicine
mlHsu et al. examine the effectiveness of Angiotensin Receptor-Neprilysin Inhibitors (ARNI) in individuals with Chronic Obstructive Pulmonary Disease (COPD) and heart failure. Findings reveal that ARNI treatment in people with both COPD and HF may lower the risk of COPD exacerbations, respiratory failure, and respiratory tract infections.
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November 12, 2025 at 12:31 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Zhang, Huang et al. develop mCODEGPT to automatically extract important details from clinical notes of cancer patients using LLMs without needing manual labeling by experts.

https://bit.ly/43WRpVz
#AIinMedicine
Introducing mCODEGPT as a zero-shot information extraction from clinical free text data tool for cancer research - Communications Medicine
Zhang, Huang et al. introduce mCODEGPT, a zero-shot framework that extracts named entities as structured data from clinical notes of cancer patients using Large Language Models. Their hierarchical prompt engineering approach enables accuracy information extraction without relying on expert-labelled training data.
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November 11, 2025 at 12:46 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Britsch et al. Develop a ML model to predict 48-hour mortality for intensive care unit patients throughout their stay.

https://bit.ly/4p2MpqC
#AIinHealthcare #ICU
An interpretable machine learning algorithm enables dynamic 48-hour mortality prediction during an ICU stay - Communications Medicine
Britsch et al. develop a dynamic machine learning model that predicts 48-hour mortality for intensive care unit patients throughout their stay. The model shows robust performance across disease groups and timepoints, offering interpretable, clinically relevant risk categorization.
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November 10, 2025 at 9:08 PM
Reposted by Communications Medicine
⭐New Publication Alert⭐

Published October 15, 2025 in @commsmed.nature.com 'Associations of maternal and paternal characteristics with cardiac malformations using real-world data and machine learning.'

➡️ Read paper: www.nature.com/articles/s43...

#cardiometabolichealth #machinelearning
November 6, 2025 at 4:40 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Brown et al. use machine learning to detect risk factors for fetal heart defects using clinical conditions of the parents.

https://bit.ly/47LgUu6

@jeremypb.bsky.social

#FetalHealth
Associations of maternal and paternal characteristics with cardiac malformations using real-world data and machine learning - Communications Medicine
Brown et al. apply statistical and unsupervised machine learning methods to identify and characterize associations between maternal and paternal characteristics with infant cardiac malformations. Known risk factors were identified alongside potential signals, which warrant further investigation.
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November 7, 2025 at 12:31 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Cente et al. find that repetitive heading of the ball is associated with biochemical alterations, reduction in focused attention, and cognitive flexibility in female soccer players ⚽

https://bit.ly/4hHnMgy
#WomenInSports
Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players - Communications Medicine
Cente et al. investigate the acute effects of mild repetitive head impacts in female soccer players. Findings reveal that female players are more sensitive to head impacts compared to males, as manifested by short-term decline in cognitive performance, altered plasma tau protein profile, and initiation of neuroprotective pathways.
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November 6, 2025 at 12:46 PM
🚨 NEW RESEARCH! ⚕️ 🩺

La Porta et al. develop an algorithm to analyze gene expression data in HER2-breast cancer patients to predict immunotherapy response.

https://bit.ly/4nA4hrH
#BreastCancer
Predicting the response to immunotherapy from gene expression data in HER2-negative breast cancer - Communications Medicine
La Porta et al. present ARIADNE, an algorithm to analyze gene expression data in HER2-breast cancer patients. The predictive ability of response to immunotherapy is improved when complemented by a cytokine score.
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November 5, 2025 at 12:32 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Keeler et al. report an updated systematic review and meta-analysis of peripheral #cytokine concentrations in individuals with eating disorders.

https://bit.ly/3WCT8vq

@jhnnklr @kingsedresearch
#EatingDisorders
Cytokine concentrations in people with eating disorders: A comprehensive updated systematic review and meta-analysis - Communications Medicine
Keeler et al. report an updated meta-analysis of peripheral cytokine concentrations in individuals with eating disorders. Results reveal elevations in interleukin (IL)-6 and IL-15 and reductions in IL-7 in people with anorexia nervosa in comparison to healthy controls, and no elevations in pro-inflammatory cytokines in people with bulimia nervosa.
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November 4, 2025 at 1:31 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Lyu et al. develop a patient-specific virtual coronary intervention (VCI) framework that enables real-time, non-invasive simulation of percutaneous coronary intervention (PCI).

https://bit.ly/3Jnibj0

#CardiovascularHealth #DigitalTwin
Predictive computational framework to provide a digital twin for personalized cardiovascular medicine - Communications Medicine
Lyu et al. develop a patient-specific virtual coronary intervention (VCI) framework that enables real-time, non-invasive simulation of percutaneous coronary intervention (PCI). This technique accurately predicts post-PCI physiology and vessel morphology, offering a promising tool for optimizing pre-procedural planning and enhancing PCI outcomes.
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October 30, 2025 at 12:58 PM
🚨 NEW RESEARCH! ⚕️ 🩺

Shukla et al. develop a PET/CT agent, [68Ga]Ga-DOTA-mDesmo, targeting vasopressin V1b receptors overexpressed in ACTH-secreting pituitary tumors causing Cushing’s disease.

https://bit.ly/4hv68N4

#MedicalResearch #CushingsDisease
Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s disease - Communications Medicine
Shukla et al. develop a PET/CT agent, [68Ga]Ga-DOTA-mDesmo, targeting vasopressin V1b receptors overexpressed in ACTH-secreting pituitary tumors causing Cushing’s disease. Their preclinical findings support its potential use for functional and anatomical identification of tumors that are otherwise difficult to detect.
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October 29, 2025 at 11:56 AM
🚨 NEW RESEARCH! ⚕️ 🩺

Pais et al. examine dopamine function and eating behavior via brain imaging. Striatal dopaminergic dysfunction may increase the incentive salience of food cues with bariatric surgery appearing to reverse these disruptions.
PET/fMRI demonstrates that bariatric surgery may reverse striatal dopaminergic dysfunction in women with obesity - Communications Medicine
Pais et al. use multimodal brain imaging to examine dopamine function and eating behavior. Striatal dopaminergic dysfunction in obesity may increase the incentive salience of food cues, promoting cravings and compulsive eating, with bariatric surgery appearing to reverse these molecular and functional disruptions.
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October 28, 2025 at 12:33 PM
🚨 NEW COMMENT 🩺

Connolly et al. describe the International Health Cohorts Consortium (IHCC), a global initiative aimed at enhancing genomic databases through inclusion of ancestral groups, promoting collaboration and cutting-edge research.
The International Health Cohorts Consortium (IHCC) advances population health research and genomic discovery - Communications Medicine
Connolly et al. describe the International Health Cohorts Consortium (IHCC), a global initiative that is closing gaps in genomic databases by representation of different ancestral groups, promoting academic and industry collaborations, and supporting cutting-edge research in global health. A summary of the collective resources of 69 member cohorts, representing over 34 million people is discussed.
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October 27, 2025 at 11:48 AM
🚨 NEW PERSPECTIVE ⚕️ 🩺

Alam et al. outline key technical and ethical challenges in sensor-based digital phenotyping for mental health. They propose standardization strategies to enhance data reliability, scalability and global applicability.
Challenges and standardisation strategies for sensor-based data collection for digital phenotyping - Communications Medicine
Alam et al. outline key technical and ethical challenges in sensor-based digital phenotyping for mental health. They propose standardisation strategies to enhance data reliability, scalability and global applicability.
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October 24, 2025 at 10:43 AM
🚨 NEW COMMENT⚕️ 🩺

Sagandira highlights how agile local API manufacturing could serve as a strategic approach for enhancing health and economic security. This could reshape Africa’s pharmaceutical sector enabling sustainable medicine access.
Agile local manufacturing of active pharmaceutical ingredients in Africa could improve health security and economic growth - Communications Medicine
Sagandira highlights how agile local API manufacturing could serve as a strategic approach for enhancing health and economic security. This could reshape Africa’s pharmaceutical sector enabling sustainable medicine access.
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October 23, 2025 at 10:40 AM
🚨 NEW RESEARCH! ⚕️ 🩺

Nakao et al. conduct and validate a phenome-wide association study on foveal thickness and find DPF3 correlates with a reduced risk of arrhythmia.

https://bit.ly/4o2Xdox

#CardiovascularHealth #Arrhythmia #MedicalResearch
A genome-wide association between foveal thickness and arrhythmia - Communications Medicine
Nakao et al. conduct and validate a phenome-wide association study on foveal thickness and find DPF3 (rs4903064) correlates with a reduced risk of arrhythmia, specifically premature cardiac complex, suggesting a link between foveal thickness and cardiovascular health.
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October 22, 2025 at 10:23 AM
🚨 NEW RESEARCH! ⚕️ 🩺

Damasio et al. develop a discharge summary system based on large language models to support the generation of summaries from clinical notes demonstrating its potential to assist healthcare professionals in routine tasks.
Development and evaluation of a clinical note summarization system using large language models - Communications Medicine
Damasio et al. develop a discharge summary system based on large language models using feedback from both physicians and patients. The results show that the AI-generated model can accurately support the generation of summaries from clinical notes demonstrating its potential to assist healthcare professionals in routine tasks.
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October 21, 2025 at 11:18 AM
Reposted by Communications Medicine
Ischemic heart disease (IHD) is a leading cause of death world-wide due to its heterogeneous nature yet homogeneous treatment.

Amalie Dahl @amdahl05.bsky.social et al used cluster algorithm to identify subgroups with different risk profiles and different patterns, improving diagnosis.

#Science
October 17, 2025 at 9:21 AM
🚨 PERSPECTIVE! ⚕

Azubuike et al. discuss the physical, economic and cultural barriers limiting access to healthcare for people with disabilities. They argue the need for equitable healthcare and propose approaches to enable this to be introduced
Equity and social justice perspectives on disability inclusion in healthcare services in Nigeria - Communications Medicine
Azubuike et al. discuss the physical, economic, and cultural barriers limiting access to healthcare for people with disabilities. They argue the need for equitable healthcare and propose approaches to enable this to be introduced.
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October 17, 2025 at 10:01 AM