W. Florian Fricke
@wffricke.bsky.social
Human Microbiome Research
Reposted by W. Florian Fricke
Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....
Distinguishing diet- and microbe-derived metabolites in the human gut - Microbiome
Background Human gut microbes metabolize food and host secretions, consuming and producing small molecules that are important to health and homeostasis. Here, we present an atlas of diet- and microbio...
microbiomejournal.biomedcentral.com
October 18, 2025 at 7:07 PM
Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....
"both air sharing and physical contact enabled bidirectional transmission: U.S. mucus-degrading taxa (e.g., Akkermansia) was transferred into Thai microbiomes, while Thai-derived, potentially health-promoting bacteria colonized U.S. microbiomes." doi.org/10.1080/1949...
October 8, 2025 at 7:30 AM
"both air sharing and physical contact enabled bidirectional transmission: U.S. mucus-degrading taxa (e.g., Akkermansia) was transferred into Thai microbiomes, while Thai-derived, potentially health-promoting bacteria colonized U.S. microbiomes." doi.org/10.1080/1949...
Reposted by W. Florian Fricke
We're hiring a #postdoc with knowledge of the #microbiome, #microbiology, #bioinformatics, #computationalbiology to understand the role of the vaginal microbiome in women's health. #Baltimore #womenshealth
Learn more: bit.ly/CAMRIpostdoc
Learn more: bit.ly/CAMRIpostdoc
October 1, 2025 at 6:13 PM
We're hiring a #postdoc with knowledge of the #microbiome, #microbiology, #bioinformatics, #computationalbiology to understand the role of the vaginal microbiome in women's health. #Baltimore #womenshealth
Learn more: bit.ly/CAMRIpostdoc
Learn more: bit.ly/CAMRIpostdoc
Reposted by W. Florian Fricke
In #Microbiome:
🦠Exploring how the microbiome influences fertility & preconception health
🚨Offering a systems-level lens through which to understand & improve reproductive health by linking diet, immunity, metabolism & hormonal signaling
Read more👉 doi.org/p7cw
🦠Exploring how the microbiome influences fertility & preconception health
🚨Offering a systems-level lens through which to understand & improve reproductive health by linking diet, immunity, metabolism & hormonal signaling
Read more👉 doi.org/p7cw
October 1, 2025 at 8:34 AM
In #Microbiome:
🦠Exploring how the microbiome influences fertility & preconception health
🚨Offering a systems-level lens through which to understand & improve reproductive health by linking diet, immunity, metabolism & hormonal signaling
Read more👉 doi.org/p7cw
🦠Exploring how the microbiome influences fertility & preconception health
🚨Offering a systems-level lens through which to understand & improve reproductive health by linking diet, immunity, metabolism & hormonal signaling
Read more👉 doi.org/p7cw
Cool paper: doi.org/10.1016/j.ce...
"different fermentation products [profiles] released [vary a lot more depending on] microbiome composition [than] daily production of bacterial biomass + release of fermentation products" "diet not microbiota [is] dominant factor for fermentation product harvest"
"different fermentation products [profiles] released [vary a lot more depending on] microbiome composition [than] daily production of bacterial biomass + release of fermentation products" "diet not microbiota [is] dominant factor for fermentation product harvest"
Redirecting
doi.org
September 9, 2025 at 9:59 AM
Cool paper: doi.org/10.1016/j.ce...
"different fermentation products [profiles] released [vary a lot more depending on] microbiome composition [than] daily production of bacterial biomass + release of fermentation products" "diet not microbiota [is] dominant factor for fermentation product harvest"
"different fermentation products [profiles] released [vary a lot more depending on] microbiome composition [than] daily production of bacterial biomass + release of fermentation products" "diet not microbiota [is] dominant factor for fermentation product harvest"
Can we predict small intestinal microbiota traits from saliva? Read our new paper “Contamination-controlled upper gastrointestinal microbiota profiling reveals salivary-duodenal community types linked to opportunistic pathogen carriage and inflammation”, doi.org/10.1080/1949...
Contamination-controlled upper gastrointestinal microbiota profiling reveals salivary-duodenal community types linked to opportunistic pathogen carriage and inflammation
The upper gastrointestinal (uGI) microbiota has been implicated in infectious, metabolic, and immunological conditions, yet remains poorly characterized due to invasive sampling and low microbial b...
doi.org
August 19, 2025 at 3:22 PM
Can we predict small intestinal microbiota traits from saliva? Read our new paper “Contamination-controlled upper gastrointestinal microbiota profiling reveals salivary-duodenal community types linked to opportunistic pathogen carriage and inflammation”, doi.org/10.1080/1949...
Reposted by W. Florian Fricke
Microbial community-scale metabolic models (MCMMs) map gut microbiome composition & dietary context to functional outputs, at scale.
Here, we describe these emerging tools & their utility to both basic & translational microbiome research. @natmicrobiol.nature.com
www.nature.com/articles/s41...
Here, we describe these emerging tools & their utility to both basic & translational microbiome research. @natmicrobiol.nature.com
www.nature.com/articles/s41...
Moving from genome-scale to community-scale metabolic models for the human gut microbiome - Nature Microbiology
In this Perspective, Deiner, Gibbons and colleagues describe the current strengths and limitations of microbial community-scale metabolic models in microbiome research.
www.nature.com
April 11, 2025 at 2:38 PM
Microbial community-scale metabolic models (MCMMs) map gut microbiome composition & dietary context to functional outputs, at scale.
Here, we describe these emerging tools & their utility to both basic & translational microbiome research. @natmicrobiol.nature.com
www.nature.com/articles/s41...
Here, we describe these emerging tools & their utility to both basic & translational microbiome research. @natmicrobiol.nature.com
www.nature.com/articles/s41...
Reposted by W. Florian Fricke
New editorial at Microbiome 🦠 !
Co-authored by the Senior Editors, it aims to highlight current challenges in the field of environmental and host-associated microbiome research and provides a blueprint for contemporary studies of the microbiomes.
microbiomejournal.biomedcentral.com/articles/10....
Co-authored by the Senior Editors, it aims to highlight current challenges in the field of environmental and host-associated microbiome research and provides a blueprint for contemporary studies of the microbiomes.
microbiomejournal.biomedcentral.com/articles/10....
A blueprint for contemporary studies of microbiomes - Microbiome
This editorial piece co-authored by the Senior Editors at Microbiome aims to highlight current challenges in the field of environmental and host-associated microbiome research. We also take the opport...
microbiomejournal.biomedcentral.com
April 8, 2025 at 9:46 AM
New editorial at Microbiome 🦠 !
Co-authored by the Senior Editors, it aims to highlight current challenges in the field of environmental and host-associated microbiome research and provides a blueprint for contemporary studies of the microbiomes.
microbiomejournal.biomedcentral.com/articles/10....
Co-authored by the Senior Editors, it aims to highlight current challenges in the field of environmental and host-associated microbiome research and provides a blueprint for contemporary studies of the microbiomes.
microbiomejournal.biomedcentral.com/articles/10....
Reposted by W. Florian Fricke
Sawhney et al. followed 52 infants from birth to age 8, uncovering how gut microbiomes shift, stabilize, and evolve. A key finding: the emergence and timing of Bacteroides- and Prevotella-dominated enterotypes. 👶🧬 1/n
Gut microbiome evolution from infancy to 8 years of age - Nature Medicine
In a unique cohort of twins followed from birth to 8 years of age, shotgun sequencing of stool samples reveals that the transmission, persistence and evolutionary adaptation of bacterial strains are s...
doi.org
April 7, 2025 at 8:03 AM
Sawhney et al. followed 52 infants from birth to age 8, uncovering how gut microbiomes shift, stabilize, and evolve. A key finding: the emergence and timing of Bacteroides- and Prevotella-dominated enterotypes. 👶🧬 1/n
Reposted by W. Florian Fricke
Principles of gut microbiota assembly
Principles of gut microbiota assembly
The gut microbiota plays a critical role in human health, yet its taxonomic complexity, interpersonal variability, and resistance to change in adulthood present challenges for understanding the factors driving shifts in its composition and function. Here,…
dlvr.it
March 15, 2025 at 7:23 PM
Principles of gut microbiota assembly
Minimal lasting gut microbiome perturbation after antibiotic (amoxicillin) treatment in children, which mostly affected bifidobacteria: microbiomejournal.biomedcentral.com/articles/10....
Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants - Microbiome
Background The evolving infant gut microbiome influences host immune development and later health outcomes. Early antibiotic exposure could impact microbiome development and contribute to poor outcome...
microbiomejournal.biomedcentral.com
February 17, 2025 at 11:26 AM
Minimal lasting gut microbiome perturbation after antibiotic (amoxicillin) treatment in children, which mostly affected bifidobacteria: microbiomejournal.biomedcentral.com/articles/10....
Microbiota assembly in SPF mice: rdcu.be/d9yMn - No bifidobacteria in neonatal mice, no clear maternal source of pioneer strains.
Bacterial community assembly of specific pathogen-free neonatal mice | Microbiome
rdcu.be
February 12, 2025 at 10:18 AM
Microbiota assembly in SPF mice: rdcu.be/d9yMn - No bifidobacteria in neonatal mice, no clear maternal source of pioneer strains.
Great study + opportunity to repost old tweets about our related meta-analysis: www.sciencedirect.com/science/arti..., which was smaller + focused on maternal strain transmission but also early-life #microbiome maturation, incl. oxygen-tolerant to intolerant species-dominated microbiome transition.
February 3, 2025 at 9:25 AM
Great study + opportunity to repost old tweets about our related meta-analysis: www.sciencedirect.com/science/arti..., which was smaller + focused on maternal strain transmission but also early-life #microbiome maturation, incl. oxygen-tolerant to intolerant species-dominated microbiome transition.
“The gut microbiota predicts and time-restricted feeding delays experimental colitis” New paper out from our group in GutMicrobes: www.tandfonline.com/doi/full/10..... Congratulations to first authors Hannah Ruple and Eva Haasis. (1/x)
The gut microbiota predicts and time-restricted feeding delays experimental colitis
The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointes...
www.tandfonline.com
January 24, 2025 at 2:45 PM
“The gut microbiota predicts and time-restricted feeding delays experimental colitis” New paper out from our group in GutMicrobes: www.tandfonline.com/doi/full/10..... Congratulations to first authors Hannah Ruple and Eva Haasis. (1/x)
Reposted by W. Florian Fricke
Our study @cellpress.bsky.social finds healthy Canadians that consume a non-industrialized-type #diet can modulate their #microbiome, boost beneficial metabolites and improve their health. In just 3 weeks:
LDL cholesterol ↓17%
fasting glucose ↓6%
CRP ↓ 14%
www.cell.com/cell/fulltex...
LDL cholesterol ↓17%
fasting glucose ↓6%
CRP ↓ 14%
www.cell.com/cell/fulltex...
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation
Is it possible to restore the human gut microbiome in industrialized settings and
reintroduce microbial species that have been lost? In healthy adults, Li et al. found
that consuming a diet mimicking ...
www.cell.com
January 23, 2025 at 5:10 PM
Our study @cellpress.bsky.social finds healthy Canadians that consume a non-industrialized-type #diet can modulate their #microbiome, boost beneficial metabolites and improve their health. In just 3 weeks:
LDL cholesterol ↓17%
fasting glucose ↓6%
CRP ↓ 14%
www.cell.com/cell/fulltex...
LDL cholesterol ↓17%
fasting glucose ↓6%
CRP ↓ 14%
www.cell.com/cell/fulltex...
Reposted by W. Florian Fricke
🎉New article from our team demonstating that a #microbiota derived #bileacid improves hepatic #cholesterol levels in mice with cancer #cachexia! Congratulations to Morgane Thibaut & Martin Roumain! Thanks to our collaborators, the FNRS and the @welbio.bsky.social www.tandfonline.com/doi/full/10....
The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia
Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host me...
www.tandfonline.com
January 13, 2025 at 6:46 PM
🎉New article from our team demonstating that a #microbiota derived #bileacid improves hepatic #cholesterol levels in mice with cancer #cachexia! Congratulations to Morgane Thibaut & Martin Roumain! Thanks to our collaborators, the FNRS and the @welbio.bsky.social www.tandfonline.com/doi/full/10....
Reposted by W. Florian Fricke
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by W. Florian Fricke
New research shows gut physiology, e.g. transit time and pH, influence microbiome variation and metabolism. These findings implicate a personalized approach and repeated sampling in microbiome studies to capture individual differences and daily dynamics. #Microbiome
Today we publish an (in my opinion) important paper in
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
Gut physiology and environment explain variations in human gut microbiome composition and metabolism - Nature Microbiology
An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.
www.nature.com
November 27, 2024 at 1:53 PM
New research shows gut physiology, e.g. transit time and pH, influence microbiome variation and metabolism. These findings implicate a personalized approach and repeated sampling in microbiome studies to capture individual differences and daily dynamics. #Microbiome
Reposted by W. Florian Fricke
We found something interesting in the evolution of plant microbiota. It is under review and we published the preprint today. Avi Bograd from my lab analyzed the genomes of 38,912 bacteria and identified a clear depletion of all MGE types in plant-associated bacteria vs. non-plant associated bacteria
November 19, 2024 at 8:46 AM
We found something interesting in the evolution of plant microbiota. It is under review and we published the preprint today. Avi Bograd from my lab analyzed the genomes of 38,912 bacteria and identified a clear depletion of all MGE types in plant-associated bacteria vs. non-plant associated bacteria
Reposted by W. Florian Fricke
Hot off the press: "Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations" www.sciencedirect.com/science/arti...
See below for @suguru-nishijima.bsky.social 's thread on the preprint!
#microsky #microbiome
See below for @suguru-nishijima.bsky.social 's thread on the preprint!
#microsky #microbiome
November 13, 2024 at 4:29 PM
Hot off the press: "Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations" www.sciencedirect.com/science/arti...
See below for @suguru-nishijima.bsky.social 's thread on the preprint!
#microsky #microbiome
See below for @suguru-nishijima.bsky.social 's thread on the preprint!
#microsky #microbiome