Weisong Zhao
@weisongzhao.bsky.social
🎓 PhD Candidate | Research Areas: Osteosarcoma Genomics & Sarcoma PDX Biobank & ecDNA
Reposted by Weisong Zhao
Cool update in Ensembl VEP (release 115):
You can now annotate structural variants with @gnomad-project.bsky.social allele frequencies AND ClinVar clinical significance
Perfect for filtering & interpreting SVs!
More info on our blog (zurl.co/3lZjy)
#genomics #bioinformatics
You can now annotate structural variants with @gnomad-project.bsky.social allele frequencies AND ClinVar clinical significance
Perfect for filtering & interpreting SVs!
More info on our blog (zurl.co/3lZjy)
#genomics #bioinformatics
Cool stuff Ensembl VEP can do: annotate structural variants with gnomAD allele frequencies and ClinVar clinical significance – Ensembl Blog
zurl.co
October 10, 2025 at 1:55 PM
Cool update in Ensembl VEP (release 115):
You can now annotate structural variants with @gnomad-project.bsky.social allele frequencies AND ClinVar clinical significance
Perfect for filtering & interpreting SVs!
More info on our blog (zurl.co/3lZjy)
#genomics #bioinformatics
You can now annotate structural variants with @gnomad-project.bsky.social allele frequencies AND ClinVar clinical significance
Perfect for filtering & interpreting SVs!
More info on our blog (zurl.co/3lZjy)
#genomics #bioinformatics
Reposted by Weisong Zhao
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Reposted by Weisong Zhao
Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social
October 3, 2025 at 4:48 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social
Reposted by Weisong Zhao
Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aberrant EZHIP expression drives tumorigenesis in osteosarcoma - Nature Communications
Osteosarcomas (OS) are aggressive bone tumors which have no actionable recurrent driver mutations. Here the authors identify aberrant expression of EZHIP in a subset of OS patients as an oncogenic dri...
www.nature.com
August 1, 2025 at 10:09 PM
Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Weisong Zhao
Reposted by Weisong Zhao
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC - Nature
In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.
go.nature.com
March 12, 2025 at 7:34 PM
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
Reposted by Weisong Zhao
Chromothripsis in cancer. #Chromothripsis #Cancer #GenomicRearrangements #ChromosomalShattering #Genomics #NatureReviewsCancer #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chromothripsis in cancer - Nature Reviews Cancer
Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...
www.nature.com
November 16, 2024 at 11:54 AM
Chromothripsis in cancer. #Chromothripsis #Cancer #GenomicRearrangements #ChromosomalShattering #Genomics #NatureReviewsCancer #BioSky #SciSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Weisong Zhao
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...
Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature
A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...
www.nature.com
January 8, 2025 at 10:58 PM
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...
Reposted by Weisong Zhao
🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social
doi.org/10.1158/2159...
doi.org/10.1158/2159...
Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...
doi.org
February 6, 2025 at 5:00 PM
🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social
doi.org/10.1158/2159...
doi.org/10.1158/2159...