Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
@wajihjawhar.bsky.social
Your friendly neighborhood geneticist 🇱🇧
Pediatric cancer epigenetics 🧬 | CCS and TFRI scholar 🇨🇦 | PhDc Jabado & Garzia labs @McGill.ca
Pediatric cancer epigenetics 🧬 | CCS and TFRI scholar 🇨🇦 | PhDc Jabado & Garzia labs @McGill.ca
Pinned
Aberrant EZHIP expression drives tumorigenesis in osteosarcoma - Nature Communications
Osteosarcomas (OS) are aggressive bone tumors which have no actionable recurrent driver mutations. Here the authors identify aberrant expression of EZHIP in a subset of OS patients as an oncogenic dri...
www.nature.com
Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
🔬 A study from The Institute & Lady Davis Institute uncovers new mechanisms of osteosarcoma, the most common bone cancer in youth. Toward more targeted therapies.
@cusm-muhc.bsky.social @healthsciences.mcgill.ca
➡️ rimuhc.ca/-/genomic-st...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca
➡️ rimuhc.ca/-/genomic-st...
September 16, 2025 at 1:54 PM
🔬 A study from The Institute & Lady Davis Institute uncovers new mechanisms of osteosarcoma, the most common bone cancer in youth. Toward more targeted therapies.
@cusm-muhc.bsky.social @healthsciences.mcgill.ca
➡️ rimuhc.ca/-/genomic-st...
@cusm-muhc.bsky.social @healthsciences.mcgill.ca
➡️ rimuhc.ca/-/genomic-st...
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
August 18, 2025 at 12:23 PM
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
The @terryfoxresearch.bsky.social @marathonofhope.bsky.social cancer centres network has now processed over 10,000 patient genomic profiles, with over 5,300 complete clinical data sets, and now comprises 50 member institutions. A truly national effort inspired by an inspirational Canadian. 🇨🇦 🤯
August 7, 2025 at 9:59 PM
The @terryfoxresearch.bsky.social @marathonofhope.bsky.social cancer centres network has now processed over 10,000 patient genomic profiles, with over 5,300 complete clinical data sets, and now comprises 50 member institutions. A truly national effort inspired by an inspirational Canadian. 🇨🇦 🤯
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
Epigenetics Update - Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation bit.ly/47khG2x
Hsiang-Ying Lee and Nian Liu in Cell
#Epigenetics #Bivalency #HisMods #Transposons
---
High-resolution insights without cell sorting; epigenometech.com
Hsiang-Ying Lee and Nian Liu in Cell
#Epigenetics #Bivalency #HisMods #Transposons
---
High-resolution insights without cell sorting; epigenometech.com
August 7, 2025 at 8:19 AM
Epigenetics Update - Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation bit.ly/47khG2x
Hsiang-Ying Lee and Nian Liu in Cell
#Epigenetics #Bivalency #HisMods #Transposons
---
High-resolution insights without cell sorting; epigenometech.com
Hsiang-Ying Lee and Nian Liu in Cell
#Epigenetics #Bivalency #HisMods #Transposons
---
High-resolution insights without cell sorting; epigenometech.com
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk #sarcomas
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas - Nature Communications
Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes...
www.nature.com
August 5, 2025 at 1:56 PM
Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk #sarcomas
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aberrant EZHIP expression drives tumorigenesis in osteosarcoma - Nature Communications
Osteosarcomas (OS) are aggressive bone tumors which have no actionable recurrent driver mutations. Here the authors identify aberrant expression of EZHIP in a subset of OS patients as an oncogenic dri...
www.nature.com
August 1, 2025 at 10:09 PM
Finally made it to bsky! For my first post here, I am happy to share our work that was published in @natcomms.nature.com We discover that #EZHIP expression and K27me3 loss are prevalent events in high-grade #osteosarcoma.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Wajih Jawharوجيه جوهر 🇱🇧🇨🇦
On this final day of Sarcoma Awareness Month, we're sharing a breakthrough that brings new hope to patients with osteosarcoma – the same cancer that set Terry Fox on his Marathon of Hope.
📖 Read more: www.tfri.ca/updates/news...
@terryfoxfoundation.bsky.social @ccsresearch.bsky.social @mcgill.ca
📖 Read more: www.tfri.ca/updates/news...
@terryfoxfoundation.bsky.social @ccsresearch.bsky.social @mcgill.ca
July 31, 2025 at 9:53 PM
On this final day of Sarcoma Awareness Month, we're sharing a breakthrough that brings new hope to patients with osteosarcoma – the same cancer that set Terry Fox on his Marathon of Hope.
📖 Read more: www.tfri.ca/updates/news...
@terryfoxfoundation.bsky.social @ccsresearch.bsky.social @mcgill.ca
📖 Read more: www.tfri.ca/updates/news...
@terryfoxfoundation.bsky.social @ccsresearch.bsky.social @mcgill.ca