Vincent Marcangeli
@vincentmarcangeli.bsky.social
PhD student at UQAM. Skeletal muscle physiology, mitochondrial biology, mitophagy, aging, physical activity.
Pinned
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPa...
physoc.onlinelibrary.wiley.com
November 22, 2025 at 5:08 PM
Mitochondrial dynamics proteins have other functions than just regulating mito dynamics, but they are often forgotten.
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Congrats to the team and especially Rémi Chaney and @gillesgouspillou.bsky.social who did the heavy lifting on this review 💪
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Strength training improves mitochondrial bioenergetics and skeletal muscle integrity in women with Myotonic Dystrophy Type 1.
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
A 12‐Week Strength Training Improves Mitochondrial Respiration, H2O2 Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1
Background
Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats in the DMPK gene, causing the accumulation of toxic RNA that sequesters RNA-binding proteins. Clinically, DM1 is characte.....
onlinelibrary.wiley.com
November 18, 2025 at 9:14 PM
Strength training improves mitochondrial bioenergetics and skeletal muscle integrity in women with Myotonic Dystrophy Type 1.
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Thanks to everyone involved, notably @gillesgouspillou.bsky.social, @jpleduc-gaudet.bsky.social, E. Duchesne, L. Girard-Coté.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Vincent Marcangeli
🚨FUTURE LEADERS SCHEME OPEN FOR APPLICATIONS🚨
We are looking for ECRs who wish to gain insights into editorial workflows and peer review!
📆Application window open until 8th August 2025
🔗 buff.ly/3z8KM6d
We are looking for ECRs who wish to gain insights into editorial workflows and peer review!
📆Application window open until 8th August 2025
🔗 buff.ly/3z8KM6d
July 10, 2025 at 4:43 PM
🚨FUTURE LEADERS SCHEME OPEN FOR APPLICATIONS🚨
We are looking for ECRs who wish to gain insights into editorial workflows and peer review!
📆Application window open until 8th August 2025
🔗 buff.ly/3z8KM6d
We are looking for ECRs who wish to gain insights into editorial workflows and peer review!
📆Application window open until 8th August 2025
🔗 buff.ly/3z8KM6d
Reposted by Vincent Marcangeli
Our latest review is out now in @jphysiol.bsky.social
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings
Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social
doi.org/10.1113/JP28...
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings
Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social
doi.org/10.1113/JP28...
May 5, 2025 at 10:06 AM
Our latest review is out now in @jphysiol.bsky.social
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings
Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social
doi.org/10.1113/JP28...
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings
Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social
doi.org/10.1113/JP28...
Reposted by Vincent Marcangeli
Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse-induced atrophy
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse‐induced atrophy
Abstract figure legend Common human and rodent muscle disuse models and associated changes in skeletal muscle mitochondrial function; respiration, redox stress and apoptotic cell death. I–V, complexe...
physoc.onlinelibrary.wiley.com
May 5, 2025 at 5:49 PM
Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse-induced atrophy
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Vincent Marcangeli
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 3:56 AM
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Reposted by Vincent Marcangeli
Our lab is excited to be a part of this enormous $23.8 million 'MitoRevolution' initiative led by Ana Andreazza, Scientific Director of Mito2i, and colleagues. We will be investigating the potential for mitochondrial transplantation in preclinical models of muscle disorders.
www.mitoinnovation.com
www.mitoinnovation.com
April 16, 2025 at 12:08 AM
Our lab is excited to be a part of this enormous $23.8 million 'MitoRevolution' initiative led by Ana Andreazza, Scientific Director of Mito2i, and colleagues. We will be investigating the potential for mitochondrial transplantation in preclinical models of muscle disorders.
www.mitoinnovation.com
www.mitoinnovation.com
Reposted by Vincent Marcangeli
Scientists have created the first map of mitochondria throughout the entire brain
https://go.nature.com/4c8CLNM
https://go.nature.com/4c8CLNM
First map of human brain mitochondria is ‘groundbreaking’ achievement
Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
go.nature.com
March 31, 2025 at 1:51 PM
Scientists have created the first map of mitochondria throughout the entire brain
https://go.nature.com/4c8CLNM
https://go.nature.com/4c8CLNM
Here comes the sun: the central role of human and clinical physiology in the era of multi-omics and inter-organ crosstalk | J Physiol
physoc.onlinelibrary.wiley.com/doi/full/10....
physoc.onlinelibrary.wiley.com/doi/full/10....
Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
March 31, 2025 at 5:35 PM
Here comes the sun: the central role of human and clinical physiology in the era of multi-omics and inter-organ crosstalk | J Physiol
physoc.onlinelibrary.wiley.com/doi/full/10....
physoc.onlinelibrary.wiley.com/doi/full/10....
Reposted by Vincent Marcangeli
www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity - Nature
The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...
www.nature.com
March 26, 2025 at 5:41 PM
www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity
A human brain map of mitochondrial respiratory capacity and diversity
Reposted by Vincent Marcangeli
2 new teaching focused tenure track faculty positions in my dept.
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
Assistant Professor in Exercise Physiology and Metabolism
Assistant Professor in Exercise Physiology and Metabolism
careers.uoguelph.ca
March 24, 2025 at 11:37 AM
2 new teaching focused tenure track faculty positions in my dept.
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
careers.uoguelph.ca/job/Guelph-A...
Reposted by Vincent Marcangeli
Out in this month's issue of Aging Cell. Motor neurons do better in the presence of primary human muscle cells from older exercisers vs non-exercisers.
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner
Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur....
doi.org
March 20, 2025 at 2:35 PM
Out in this month's issue of Aging Cell. Motor neurons do better in the presence of primary human muscle cells from older exercisers vs non-exercisers.
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...
« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ».
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
Sedentary death syndrome - PubMed
Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physical inactivity, very...
pubmed.ncbi.nlm.nih.gov
March 12, 2025 at 12:35 PM
« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ».
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
21-year-old gem.
pubmed.ncbi.nlm.nih.gov/15317985/
Reposted by Vincent Marcangeli
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...
pubmed.ncbi.nlm.nih.gov
March 10, 2025 at 4:23 PM
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Reposted by Vincent Marcangeli
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
www.nature.com
March 6, 2025 at 5:15 AM
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vincent Marcangeli
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
February 10, 2025 at 9:39 PM
Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
February 11, 2025 at 7:18 PM
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...