Russ at UF
@rthepple.bsky.social
Scientist, lifelong athlete, home cook, music lover and amateur musician, husband, father, brother, son. Research interests: aging, cancer cachexia, sepsis, skeletal muscle and mitochondria. Did I mention mitochondria?
Reposted by Russ at UF
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 11:44 AM
Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...
Reposted by Russ at UF
Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 13, 2025 at 1:19 AM
Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...
Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....
Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner
Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur...
onlinelibrary.wiley.com
March 12, 2025 at 11:12 AM
Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed
Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...
pubmed.ncbi.nlm.nih.gov
March 10, 2025 at 4:23 PM
New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/
Reposted by Russ at UF
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:
doi.org/10.1038/s415...
3/3
doi.org/10.1038/s415...
3/3
Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
doi.org
March 3, 2025 at 2:15 PM
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:
doi.org/10.1038/s415...
3/3
doi.org/10.1038/s415...
3/3
Reposted by Russ at UF
Our new review on longitudinal body comp in lung cancer is now in print!
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Body composition alterations in patients with lung cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because...
journals.physiology.org
February 24, 2025 at 9:41 PM
Our new review on longitudinal body comp in lung cancer is now in print!
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Reposted by Russ at UF
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
scim.ag
February 19, 2025 at 4:54 PM
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
Reposted by Russ at UF
Reposted by Russ at UF
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 11:17 AM
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Reposted by Russ at UF
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus
Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over the past 2 decades, tran…
www.sciencedirect.com
February 16, 2025 at 2:03 PM
@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...
Reposted by Russ at UF
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
Cefis et al. show that mitochondrial respiration and ROS production are not affected
during healthy muscle aging but identify altered mitochondrial calcium handling as
a potential key driving mechanis...
www.cell.com
February 11, 2025 at 7:18 PM
When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Russ at UF
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
Ruggieri et al. developed a spatial transcriptomics dataset of skeletal muscle from
the SOD1G93A ALS mouse model. Their findings highlight polyamine metabolism’s role
in muscle fiber vulnerability, sh...
www.cell.com
February 11, 2025 at 7:30 PM
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Russ at UF
Reposted by Russ at UF
Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling
This review explores the intricate processes of motor unit remodeling with a specific focus on the influence of reactive oxygen species (ROS) and oxid…
www.sciencedirect.com
February 2, 2025 at 4:36 PM
Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
How cool is this?!
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
January 30, 2025 at 12:03 PM
How cool is this?!
Reposted by Russ at UF
Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez!
rdcu.be/d7L66
rdcu.be/d7L66
Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
rdcu.be
January 28, 2025 at 9:46 AM
Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez!
rdcu.be/d7L66
rdcu.be/d7L66
Fascinating new paper relating to motoneuron changes in muscles regulating swallowing with aging. This likely has implications for limb muscle too. physoc.onlinelibrary.wiley.com/doi/full/10....
Dendritic alterations precede age‐related dysphagia and nucleus ambiguus motor neuron death
Abstract figure legend Here, we evaluate the effects of ageing on the timing and pressure generation during naturalistic water bolus swallows, using Millar catheters placed in the pharynx (purple: to...
physoc.onlinelibrary.wiley.com
January 28, 2025 at 3:00 PM
Fascinating new paper relating to motoneuron changes in muscles regulating swallowing with aging. This likely has implications for limb muscle too. physoc.onlinelibrary.wiley.com/doi/full/10....
Reposted by Russ at UF
Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨
A recent manuscript by @sulianamanley.bsky.social's lab led by @jclandoni.bsky.social describes reversible mitochondrial pearling as a driving force for mtDNA regular distribution within mitochondria.
PKmito ORANGE was used in to image mitochondrial pearling by STED microscopy in live cells.
PKmito ORANGE was used in to image mitochondrial pearling by STED microscopy in live cells.
January 24, 2025 at 12:04 PM
Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨
Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...
BREATHE Application » Breathing Research and Therapeutics Center » College of Public Health and Health Professions » University of Florida
.
breathe.phhp.ufl.edu
January 22, 2025 at 7:59 PM
Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...
Reposted by Russ at UF
Nice summary of our paper by #AdvancedScienceNews🤩
www.advancedsciencenews.com/exercising-e...
@ismcopenhagen.bsky.social
#BispebjergHospital
www.advancedsciencenews.com/exercising-e...
@ismcopenhagen.bsky.social
#BispebjergHospital
December 9, 2024 at 9:58 AM
Nice summary of our paper by #AdvancedScienceNews🤩
www.advancedsciencenews.com/exercising-e...
@ismcopenhagen.bsky.social
#BispebjergHospital
www.advancedsciencenews.com/exercising-e...
@ismcopenhagen.bsky.social
#BispebjergHospital
Reposted by Russ at UF
A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not.
December 5, 2024 at 1:55 PM
A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not.
Reposted by Russ at UF
AMPK regulates the maintenance and remodelling of the neuromuscular junction by @ngseany.bsky.social @mikhaiai.bsky.social @stephmattina.bsky.social www.sciencedirect.com/science/arti...
AMPK regulates the maintenance and remodelling of the neuromuscular junction
The neuromuscular junction (NMJ) is an electrochemical signaling apparatus essential for facilitating muscle contraction and counteracting neurodegene…
www.sciencedirect.com
November 23, 2024 at 2:43 PM
AMPK regulates the maintenance and remodelling of the neuromuscular junction by @ngseany.bsky.social @mikhaiai.bsky.social @stephmattina.bsky.social www.sciencedirect.com/science/arti...