Sara Marie Ulv Larsen
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ulvlarsen.bsky.social
Sara Marie Ulv Larsen
@ulvlarsen.bsky.social
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MD & PhD with an affection for neurobiologi | Research on #Sleep, #Glymphatics, #BrainFluidDynamics and #BrainPulsations | Based in Copenhagen
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Reposted by Sara Marie Ulv Larsen
plosbiology.org
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sleep pressure and slow-wave-rich NREM sleep exert distinct effects on cerebral vasomotion and on brain pulsations driven by respiratory and cardiac forces. Heightened sleep pressure (following 35 h of wakefulness) promotes vasomotion (yellow box). Slow-wave-rich NREM sleep enhances brain pulsations driven by the respiratory and cardiac cycles—more so in gray and white matter than in the ventricles (red boxes). The respiration- and cardiac-driven brain pulsations also intensify with deeper sleep (N3 > N2) and correlate with EEG delta power, which is a measure of slow-wave activity (light vs. dark red boxes).
November 25, 2025 at 5:40 PM
Reposted by Sara Marie Ulv Larsen
plosbiology.org
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sleep pressure and slow-wave-rich NREM sleep exert distinct effects on cerebral vasomotion and on brain pulsations driven by respiratory and cardiac forces. Heightened sleep pressure (following 35 h of wakefulness) promotes vasomotion (yellow box). Slow-wave-rich NREM sleep enhances brain pulsations driven by the respiratory and cardiac cycles—more so in gray and white matter than in the ventricles (red boxes). The respiration- and cardiac-driven brain pulsations also intensify with deeper sleep (N3 > N2) and correlate with EEG delta power, which is a measure of slow-wave activity (light vs. dark red boxes).
November 25, 2025 at 2:07 PM
Reposted by Sara Marie Ulv Larsen
medrxivpreprint.bsky.social
Sleep pressure propels cerebrovascular oscillations while sleep intensity correlates with respiration- and cardiac-driven brain pulsations https://www.medrxiv.org/content/10.1101/2024.10.16.24315580v1
Sleep pressure propels cerebrovascular oscillations while sleep intensity correlates with respiration- and cardiac-driven brain pulsations https://www.medrxiv.org/content/10.1101/2024.10.16.24315580v1
The waste-clearing flow of cerebrospinal fluid through the brain is driven by cerebrovascular, respi
www.medrxiv.org
October 18, 2024 at 6:26 AM
Reposted by Sara Marie Ulv Larsen
erictopol.bsky.social
How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien!
www.cell.com/cell/abstrac...
www.science.org/content/arti...
January 9, 2025 at 4:44 PM
Reposted by Sara Marie Ulv Larsen
sorengrubb.bsky.social
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Showing how a precapillary sphincter dilates during high blood pressure
June 10, 2025 at 7:38 PM
Reposted by Sara Marie Ulv Larsen
ianharrisonneuro.bsky.social
Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠
November 16, 2024 at 11:38 AM
Reposted by Sara Marie Ulv Larsen
jonykipnis.bsky.social
Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.
May 4, 2025 at 10:41 PM
Reposted by Sara Marie Ulv Larsen
natrevneurol.nature.com
Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease
INTRODUCTION Free-water imaging of the choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD). METHODS Our study investigated the role of free-water fraction (FWf) of CP in AD ...
alz-journals.onlinelibrary.wiley.com
May 21, 2025 at 11:43 AM