#arteriole–#capillary
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biorxiv-neursci.bsky.social
Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions. https://www.biorxiv.org/content/10.1101/2024.06.28.601145v1
Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions. https://www.biorxiv.org/content/10.1101/2024.06.28.601145v1
During neuronal activity, cerebral blood flow increases to ensure adequate glucose and oxygen supply
www.biorxiv.org
July 2, 2024 at 9:15 PM
kidneyboy.bsky.social
fluids that move out of capillary on arteriole side all needs to be returned via lymphatics. #renalresearchmeeting
December 4, 2024 at 5:43 AM
saravasconcelos.bsky.social
Saf also integrated multiple datasets, to resolve the inter-tissue heterogeneity of pancreatic ECs. This revealed the vascular hierarchy within the pancreas and identified a specialized islet #capillary population & a specialized pre-capillary arteriole population! 4/
November 14, 2024 at 12:06 AM
haoyin.bsky.social
#Pericyte-to-Pericyte #TunnelingNanoTube in normal human Macula👁️
289 TNT 11 donors

All b/w retinal capillaries (none with arteriole/venule)
Closely intertwined with GFAP+ astrocyte processes😈
Density superficial > intermediate ~ deep capillary plexi

#IOVS 2024
iovs.arvojournals.org/article.aspx...
November 18, 2024 at 8:02 PM
haoyin.bsky.social
#YAP/TAZ #HydrostaticPressure #EndothelialCell

Effects of Pressure (20 mmHg capillary, 55 mmHg arteriole) on 2D & 3D EC behaviors
⏫#SproutingAngiogenesis
mouse aortic ring
3D EC microchannel
YAP/TAZ-dependent

⏫Partial #EndMT

⏫YAP nucleation

#CommsBio 2024
www.nature.com/articles/s42...
August 22, 2024 at 11:33 AM
biorxiv-neursci.bsky.social
L-Type calcium channels and TRPC3 channels shape brain pericyte calcium signaling and hemodynamics throughout the arteriole to capillary network in vivo https://www.biorxiv.org/content/10.1101/2024.02.27.582351v1
L-Type calcium channels and TRPC3 channels shape brain pericyte calcium signaling and hemodynamics throughout the arteriole to capillary network in vivo https://www.biorxiv.org/content/10.1101/2024.02.27.582351v1
Pericytes play a crucial role in regulating cerebral blood flow (CBF) through processes like vasomot
www.biorxiv.org
February 29, 2024 at 2:17 AM
haoyin.bsky.social
Autologous #CellTherapy for 👤#ChronicThreateningLimbIschemia

CD16+ pro-arteriogenic monocyte
HB-EGF paracrine, likely +other factors
N=5
100~150 ml apheresis
30M cells im
25% cell retention by D3
⏫arteriole/capillary/peri-arteriolar macrophage by D10

#ScienceTM 2024
www.science.org/doi/10.1126/...
June 26, 2024 at 11:38 AM
haoyin.bsky.social
#Pericyte #PulmonaryHypertension
1/2

A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH

#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
January 27, 2025 at 1:41 PM
haoyin.bsky.social
Global & Arteriole-capillary transition zone #NeuroVascularCoupling imaged by #UltrasoundLocalizationMicroscopy😆

Adult endothelial Eng KO🐭
👉Arteriole dilation+tortuosity
👉Ensheath/Mesh Pericyte soma rounding
👉⏬Sensory🧠flow

@mickaeltanter.bsky.social #NatBME ‬2025
link.springer.com/article/10.1...
August 4, 2025 at 12:39 PM
hswapnil.medsky.social
Pathologies of 🐷 to human kidney transplant

3 patients - from Jayme Locke et al in @ajkd.bsky.social

Mesangial IgM/C4 deposits + cellularity seen even preimplantation, endothelial injury, even (viral) inclusion in one case

www.ajkd.org/article/S027...

#transplant #nephsky #renalpath
Fi gure 1 Case 1 xenografts. (A) Left preimplantation biopsy shows glomerulus with mild increase in mesangial matrix and segmental increase in mesangial cellularity (PASH x20). (B) Right postimplantation biopsy, POD-2, shows diffuse tubular epithelial cell necrosis with loss of nuclei and frequent granular casts. The glomerulus shows rare lumina occluded by fibrin thrombi (arrows); the rest of the capillaries are congested (PASH x20). (C) Left preimplantation biopsy; immunofluorescence shows global granular staining for IgM limited to the mesangium (FITC anti-human IgM). (D) Right preimplantation biopsy shows electron dense immune complex deposits within the expanded mesangium (Uranyl acetate and lead citrate, x4000). (E) Low power of the biopsy in D shows nearly intact foot processes; the mesangial matrix and cellularity is mildly increased, and the glomerular basement membrane appears thin (Urinayl acetate and lead citrate x1600). (F) Right postimplantation biopsy, POD-2, shows severe endothelial cell injury with loss of endothelial cell nuclei; the lumina are completely obliterated by degenerated swollen endothelial cells, fibrin tactoids (arrow) and entrapped fragmented red blood cells; the foot processes are completely effaced (Uranyl acetate and lead citrate, x3200). Figure 2 Case 2 xenografts. (A) Left preimplantation biopsy shows glomerulus with mild increase in mesangial matrix and segmental increase in mesangial cellularity; adjacent arteriole is unremarkable (PASH x20). (B) Left postimplantation biopsy, POD-3, there is moderate to severe acute tubular injury showing luminal dilatation with tubular epithelial cells simplification and frequent casts within injured tubular lumen and interstitial edema; the glomerulus, in addition to mildly increased mesangial matrix and mild mesangial hypercellularity, shows scattered inflammatory cells including PMNs (arrow) within the capillary lumina lined by swollen endothelial cells with segmental partial to near complete obliteration of the peripheral capillary lumina (PASH x20). (C) Left preimplantation biopsy; immunofluorescence shows weak but global granular staining for IgM limited to the mesangium (FITC anti-human IgM). (D) Left postimplantation biopsy, POD-1; immunofluorescence shows strong and global, granular staining for C3 predominantly limited to the mesangium (FITC anti-human C3). (E) Right preimplantation biopsy; the foot processes are nearly intact; the glomerular basement membrane appears thin (Uranyl acetate and lead citrate x3400). (F)Left preimplantation biopsy; and (G) Left postimplantation biopsy, POD-1; there are frequent electron dense immune complex deposits within the expanded mesangium (Uranyl acetate and lead citrate, x5800 and 3400 respectively). (H) Right postimplantation biopsy, POD-3, the capillary loops are lined by swollen endothelial cells with partial to near complete obliteration of the lumina; the foot processes are partially effaced (Uranyl acetate and lead citrate x2600). (I) Right postimplantation biopsy, POD-3, high power view of the glomerulus in H shows intraluminal fibrin tactoids (arrow), in addition to the subendothelial electron densities (asterisk) with microvesicular architecture (Uranyl acetate and lead Figure 3 Case 3 xenografts. (A) Left preimplantation biopsy shows glomerulus with mild increase in mesangial matrix and segmental increase in mesangial cellularity; there is no tubulointerstitial injury (PASH x20). (B) Left postimplantation biopsy, POD-7, the peritubular capillaries (arrows) contain inflammatory cells indicative of peritubular capillaritis; the tubulointerstitium shows moderate acute tubular injury and interstitial edema (PASH x20). (C) Left postimplantation biopsy, POD-3, the C4d stain is negative in the peritubular capillaries (C4d immunohistochemical stain x20). The C4d is focally positive in peritubular capillaries in postimplantation, POD-5 (D) and diffusely positive in postimplantation, POD-7 (E) biopsies (C4d immunohistochemical stain x20). (F) Right postperfusion biopsy; immunofluorescence shows global granular staining for C3, limited to the mesangium (FITC anti-human C3). (G) Right preimplantation and (H) right postperfusion biopsies; the foot processes are nearly intact; the glomerular basement membrane appears thin (Uranyl acetate and lead citrate x2600 and 1450 respectively). (I) Right postperfusion biopsy on higher power shows rare electron dense immune complex deposits (arrow) within the expanded mesangium (Uranyl acetate and lead citrate x7900). (J) Right postimplantation biopsy, POD-7, shows mildly increased mesangial matrix and segmentally swollen endothelial cells; however, no significant foot process effacement is present (Uranyl acetate and lead citrate, x2600).
July 16, 2025 at 1:39 AM
onaalbizu.bsky.social
While it's well known pwME have a low cerebral blood flow

AND:

"We found that small vessel disease, SVD, is associated with reduced synthesis of the phospholipid PIP2, which prevents the Kir2.1 channel-initiated capillary-to-arteriole electrical signaling ...
pmc.ncbi.nlm.nih.gov/articles/PMC...
PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity
Years before the emergence of infarctions or significant cognitive decline, patients with cerebral small vessel disease (SVD) show a deterioration in the ability of the brain to augment blood flow loc...
pmc.ncbi.nlm.nih.gov
March 22, 2025 at 9:47 AM
izzynchristie.bsky.social
Great to see the efforts of Barbara Lind in the Volterra lab.

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions

#womeninSTEM #astrocytes #neuroscience #glia
www.biorxiv.org/content/10.1...
Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions
During neuronal activity, cerebral blood flow increases to ensure adequate glucose and oxygen supply, a crucial mechanism known as the neurovascular coupling response. Blood is drawn from the brain’s ...
www.biorxiv.org
May 22, 2025 at 9:53 AM
biorxivpreprint.bsky.social
Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions. https://www.biorxiv.org/content/10.1101/2024.06.28.601145v1
Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses locally at arteriole-capillary junctions. https://www.biorxiv.org/content/10.1101/2024.06.28.601145v1
During neuronal activity, cerebral blood flow increases to ensure adequate glucose and oxygen supply
www.biorxiv.org
July 2, 2024 at 9:15 PM
biorxivpreprint.bsky.social
L-Type calcium channels and TRPC3 channels shape brain pericyte calcium signaling and hemodynamics throughout the arteriole to capillary network in vivo https://www.biorxiv.org/content/10.1101/2024.02.27.582351v1
L-Type calcium channels and TRPC3 channels shape brain pericyte calcium signaling and hemodynamics throughout the arteriole to capillary network in vivo https://www.biorxiv.org/content/10.1101/2024.02.27.582351v1
Pericytes play a crucial role in regulating cerebral blood flow (CBF) through processes like vasomot
www.biorxiv.org
February 29, 2024 at 2:17 AM
joe-pathology.bsky.social
The post-capillary venules are in the pathological firing line again this evening. Yikes! This one shows florid fibrinoid necrosis while a helpless arteriole looks on.😢
#LeukocytoclasticVasculitis
#pathology
#dermatology
#PathSky
February 20, 2025 at 8:25 PM
haoyin.bsky.social
Hierarchical microvasculature on a chip

Arteriole (φ400 μm #ViscousFingerPattening Collagen) -Capillary (self-assembly) -Venule

Arteriole can contract by ~2%φ

#VascularPermeability

Circulating tumor cell/T cell extravasation

Roger Kamm lab, Lab on a Chip 2023
pubs.rsc.org/en/content/a...
October 16, 2023 at 7:23 PM
sorengrubb.bsky.social
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Showing how a precapillary sphincter dilates during high blood pressure
June 10, 2025 at 7:38 PM
castltrastondrs.bsky.social
Cognitive functioning and the effects of #COVID19
molecularneurodegeneration.biomedcentral.com/articles/10....
Neurological manifestations of #LongCovid

journals.sagepub.com/doi/10.1177/...
Cognitive decline following acute 🦠infections & post covid

link.springer.com/article/10.1...
Diagram illustration of the vasculature and BL layers in the CNS. a Scheme of the CNS blood vessels and meningeal lymphatic/glymphatic system. The inset highlights the cross-section view of a meningeal artery. b Scheme of various BL layers and cellular components at the arterial/arteriole, capillary, and post-capillary venule levels in the CNS vasculature. BL: basal lamina; eBL: endothelial basal lamina; EC: endothelial cell; pBL: parenchymal basal lamina; PVM: perivascular macrophage; SMC: smooth muscle cell
October 20, 2023 at 9:50 PM
swilua.bsky.social
people talking about the lung complexity
Elena Lake • @relic_r...• 1d did you know: your lungs aren't hollow balloons, but are three-dimensional and spongey all the way through? and when you breath in and out, the sponge simply becomes more versus less inflated? @embryosophy said the texture of lungs is roughly the texture of oyster mushrooms Traches oper lobe Cardiac blue @theproteindance •17h Okay I desperately need to correct this before it gets too out of hand. There is a hollow cavity in your lungs. It's shaped like a weird twisty fractal that interlocks with the weird twisty fractal of your blood vessels because that maximizes gas exchange surface area blue @theproteindance •17h The "sponge" that people are mainly discussing is the extracellular matrix which is holding this whole thing together. It scaffolds the cells in place. Most of the lungs are dedicated to making as much blood pass by as much oxygen as possible with Mary the two to meet Native (fresh) Decellularized Gross omy Ultrastructure RB RB AS 100 um blue @theproteindance •17h Also, as for the balloon thing they do exist. They are just tiny and at the end of the bronchiole I used a histology image cause I doubt people here would be happy to see the messy dissection. You can look it up if you want though Pulmonary veins Terminal bronchiole arte Pulmonary artery Alveolus bronchiole lumen Bronchiole Pulmonary venule Bronchial nerve Pulmonary arteriole Pulmonary capillary Alveolus Pores of Kohn
November 28, 2024 at 1:19 PM