@thegodofsheep.bsky.social
Reposted
🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools.
🔗 royalsociety.org/medals-and-p...
🔗 royalsociety.org/medals-and-p...
August 28, 2025 at 6:24 PM
🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools.
🔗 royalsociety.org/medals-and-p...
🔗 royalsociety.org/medals-and-p...
Reposted
Nature research paper: One-shot design of functional protein binders with BindCraft
go.nature.com/46bhOAv
go.nature.com/46bhOAv
One-shot design of functional protein binders with BindCraft - Nature
BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.
go.nature.com
September 1, 2025 at 5:37 PM
Nature research paper: One-shot design of functional protein binders with BindCraft
go.nature.com/46bhOAv
go.nature.com/46bhOAv
Reposted
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
September 2, 2025 at 10:48 AM
Preprint: De-novo design of proteins that inhibit bacterial defenses
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications
Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Reposted
Researchers and science-policy specialists tell Nature that the plans leave the door open to political interference in science
go.nature.com/4p2O8x1
go.nature.com/4p2O8x1
Trump called for ‘gold-standard science’: how the NIH, NSF and others are answering
Some researchers say that US-agency policies provide opportunities for political interference.
go.nature.com
September 2, 2025 at 4:50 PM
Researchers and science-policy specialists tell Nature that the plans leave the door open to political interference in science
go.nature.com/4p2O8x1
go.nature.com/4p2O8x1
Reposted
Recent advances in the inference of deep viral
evolutionary history journals.asm.org/doi/10.1128/...
A review on structural phylogenetics utility and limitations
evolutionary history journals.asm.org/doi/10.1128/...
A review on structural phylogenetics utility and limitations
September 2, 2025 at 10:35 PM
Recent advances in the inference of deep viral
evolutionary history journals.asm.org/doi/10.1128/...
A review on structural phylogenetics utility and limitations
evolutionary history journals.asm.org/doi/10.1128/...
A review on structural phylogenetics utility and limitations
Reposted
Engineering a Dimeric Single-Domain Antibody for Improved Detection and neutralization of Amyloid-β oligomers][new]
Engineered dimeric sdAb for enhanced binding, neutralizing toxic amyloid-β oligomers in Alzheimer's.
Engineered dimeric sdAb for enhanced binding, neutralizing toxic amyloid-β oligomers in Alzheimer's.
September 1, 2025 at 4:04 AM
Engineering a Dimeric Single-Domain Antibody for Improved Detection and neutralization of Amyloid-β oligomers][new]
Engineered dimeric sdAb for enhanced binding, neutralizing toxic amyloid-β oligomers in Alzheimer's.
Engineered dimeric sdAb for enhanced binding, neutralizing toxic amyloid-β oligomers in Alzheimer's.
Reposted
SynGlue: AI-Driven Designer for Clinically Actionable Multi-Target Therapeutics [new]
AI designs multi-target drugs via fragment-based reasoning, data, & struct. It generated novel BRD4-VHL PROTACs with potent anti-cancer activity.
AI designs multi-target drugs via fragment-based reasoning, data, & struct. It generated novel BRD4-VHL PROTACs with potent anti-cancer activity.
September 3, 2025 at 6:05 AM
SynGlue: AI-Driven Designer for Clinically Actionable Multi-Target Therapeutics [new]
AI designs multi-target drugs via fragment-based reasoning, data, & struct. It generated novel BRD4-VHL PROTACs with potent anti-cancer activity.
AI designs multi-target drugs via fragment-based reasoning, data, & struct. It generated novel BRD4-VHL PROTACs with potent anti-cancer activity.
Reposted
The Darwin-Godel Drug Discovery Machine (DGDM): A Self-Improving AI Framework [updated]
Self-Improving AI: Auto molecule/pipeline refinement for drug discovery via dual-loop evolution & adaptive meta-learning.
Self-Improving AI: Auto molecule/pipeline refinement for drug discovery via dual-loop evolution & adaptive meta-learning.
September 2, 2025 at 6:54 AM
The Darwin-Godel Drug Discovery Machine (DGDM): A Self-Improving AI Framework [updated]
Self-Improving AI: Auto molecule/pipeline refinement for drug discovery via dual-loop evolution & adaptive meta-learning.
Self-Improving AI: Auto molecule/pipeline refinement for drug discovery via dual-loop evolution & adaptive meta-learning.