@tharaux-lenoir-lab.bsky.social
Reposted
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
October 6, 2025 at 4:19 PM
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
Reposted
Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV)
doi.org/10.1016/j.kint.2025.04.003
#OpenAccess #MedSky #NephSky @kdigo.org
doi.org/10.1016/j.kint.2025.04.003
#OpenAccess #MedSky #NephSky @kdigo.org
October 21, 2025 at 6:53 PM
Executive summary of the #KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (#IgAN) and Immunoglobulin A Vasculitis (#IgAV)
doi.org/10.1016/j.kint.2025.04.003
#OpenAccess #MedSky #NephSky @kdigo.org
doi.org/10.1016/j.kint.2025.04.003
#OpenAccess #MedSky #NephSky @kdigo.org
Reposted
Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more: kidney.pub/CJASN0910
November 23, 2025 at 8:00 PM
Among hypertensive adults with ambulatory AKI, this #ASNCJASN study found plasma biomarkers reflecting impaired kidney tubule health measured at the time of ambulatory AKI are associated with subsequent non-recovery in kidney function. Read more: kidney.pub/CJASN0910
Reposted
📚 Déjà 97 articles sur le blog 'Le #diabète dans tous ses états' !
Un contenu rigoureux et accessible.
Physiopathologie, traitements, complications, innovations…
Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org
Un contenu rigoureux et accessible.
Physiopathologie, traitements, complications, innovations…
Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org
Le Diabète dans tous ses états
Un blog, comme aucun autre, pour découvrir et tout comprendre des mille et une facettes du diabète et de l’obésité.
www.le-diabete-dans-tous-ses-etats.precidiab.org
November 14, 2025 at 6:02 AM
📚 Déjà 97 articles sur le blog 'Le #diabète dans tous ses états' !
Un contenu rigoureux et accessible.
Physiopathologie, traitements, complications, innovations…
Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org
Un contenu rigoureux et accessible.
Physiopathologie, traitements, complications, innovations…
Une ressource unique pour comprendre toutes les facettes de cette maladie complexe
www.le-diabete-dans-tous-ses-etats.precidiab.org
Reposted
Syndrome d’auto-brasserie : être ivre sans boire une goutte d’alcool
Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang.
www.lemonde.fr/blog/realite... [Rediff]
Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang.
www.lemonde.fr/blog/realite... [Rediff]
November 18, 2025 at 11:14 AM
Syndrome d’auto-brasserie : être ivre sans boire une goutte d’alcool
Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang.
www.lemonde.fr/blog/realite... [Rediff]
Ce trouble diffère du syndrome d'auto-brasserie urinaire dans lequel on trouve de l’alcool dans l’urine mais pas dans le sang.
www.lemonde.fr/blog/realite... [Rediff]
Reposted
Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation: youtu.be/oSB3CP5UDPE
Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation
In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2–binding and TIE2-activating antibody warrants investigation as a therapy in human…
youtu.be
November 11, 2025 at 7:30 PM
Video Abstract: Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation: youtu.be/oSB3CP5UDPE
Reposted
Cancer : la France doit savoir pourquoi elle est surexposée
Cancer : la France doit savoir pourquoi elle est surexposée
L’étude du « Lancet », qui a placé la France en tête des pays les plus touchés, doit servir de signal d’alarme. Qu’un pays développé ignore l’ensemble des causes d’une incidence singulière du cancer n’est pas acceptable.
www.lemonde.fr
October 11, 2025 at 9:11 AM
Cancer : la France doit savoir pourquoi elle est surexposée
Mineralocorticoid Receptor #MR inhibition in parietal epithelial cells #PEC prevents #FSGS and #crescenticGN. Furthermore, we didn’t find 11βHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal.
@isgd.bsky.social
doi.org/10.1016/j.ki...
@isgd.bsky.social
doi.org/10.1016/j.ki...
October 11, 2025 at 9:19 AM
Mineralocorticoid Receptor #MR inhibition in parietal epithelial cells #PEC prevents #FSGS and #crescenticGN. Furthermore, we didn’t find 11βHSD in PECs, suggesting that standard of care could stimulate MR, which is not optimal.
@isgd.bsky.social
doi.org/10.1016/j.ki...
@isgd.bsky.social
doi.org/10.1016/j.ki...
Reposted
Perturbation of the circadian clock in chronic diseases involving organ fibrosis
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
October 8, 2025 at 4:15 PM
Perturbation of the circadian clock in chronic diseases involving organ fibrosis
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?
Perturbation of the circadian clock in chronic diseases involving organ fibrosis
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
This review by Mukherji et al. highlights circadian mechanisms, their perturbations predisposing toward chronic disease and fibrosis, and the promise of chronotherapy: www.jci.org/articles/vie...
October 9, 2025 at 6:28 AM
Enthusiastic about this emerging field. Perhaps a key to understanding and treating the multiorgan complications of #diabetes and #metabolic syndrome?
Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!
September 26, 2025 at 3:49 PM
Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!
Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice.
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social @olilen.bsky.social
@upcite.bsky.social @inserm.fr
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social @olilen.bsky.social
@upcite.bsky.social @inserm.fr
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a …
www.sciencedirect.com
September 26, 2025 at 3:39 PM
Inhibiting MR protects against glomerular damage by preventing the activation of parietal epithelial cells. A novel mechanism that should impact medical practice.
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social @olilen.bsky.social
@upcite.bsky.social @inserm.fr
www.sciencedirect.com/science/arti...
@parcc-inserm.bsky.social @olilen.bsky.social
@upcite.bsky.social @inserm.fr
Reposted
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
go.nature.com/3KBRg2W
go.nature.com/3KBRg2W
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
go.nature.com
September 25, 2025 at 9:13 AM
Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
go.nature.com/3KBRg2W
go.nature.com/3KBRg2W
Reposted
Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
September 20, 2025 at 12:04 PM
Take a peek: This issue’s cover features 3D imaging and single-cell genomics by David A. Long @daniyaljafree.bsky.social & team, revealing lymphatic rewiring in kidney tissue with chronic transplant rejection: buff.ly/BZEw4az
Reposted
Hoover, Hacohen, Davidson @northwellhealth.bsky.social et al. analyze the intrarenal myeloid compartment in four #lupus #nephritis mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies. rupress.org/jem/article/...
September 3, 2025 at 4:15 PM
Hoover, Hacohen, Davidson @northwellhealth.bsky.social et al. analyze the intrarenal myeloid compartment in four #lupus #nephritis mouse models and 155 humans using single-cell profiling, spatial transcriptomics, and functional studies. rupress.org/jem/article/...
Reposted
Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...
September 4, 2025 at 4:03 PM
Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...
Reposted
Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study
Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011
Original article: doi.org/10.1016/j.kint.2025.04.017
#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011
Original article: doi.org/10.1016/j.kint.2025.04.017
#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
August 19, 2025 at 4:30 PM
Is #preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study
Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011
Original article: doi.org/10.1016/j.kint.2025.04.017
#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
Commentary by S Jesudason & G Piccoli
doi.org/10.1016/j.kint.2025.05.011
Original article: doi.org/10.1016/j.kint.2025.04.017
#MedSky #NephSky #CKD #diabeticnephropathy #PedsNeph
Reposted
Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline
doi.org/10.1016/j.kint.2025.07.024
#NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social
doi.org/10.1016/j.kint.2025.07.024
#NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social
September 2, 2025 at 7:13 PM
Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline
doi.org/10.1016/j.kint.2025.07.024
#NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social
doi.org/10.1016/j.kint.2025.07.024
#NephSky #MedSky #glomerulus @uwchemistry.bsky.social @uwcse.bsky.social @uwnephrology.bsky.social
Reposted
Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions
doi.org/10.1016/j.kint.2025.07.022
#NephSky #MedSky #AKI #acutekidneyinjury
doi.org/10.1016/j.kint.2025.07.022
#NephSky #MedSky #AKI #acutekidneyinjury
September 3, 2025 at 2:04 PM
Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions
doi.org/10.1016/j.kint.2025.07.022
#NephSky #MedSky #AKI #acutekidneyinjury
doi.org/10.1016/j.kint.2025.07.022
#NephSky #MedSky #AKI #acutekidneyinjury
Reposted
ICYMI: Chemotaxis as a driver in immune privilege.
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
buff.ly/Mwn8t1c
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
buff.ly/Mwn8t1c
July 26, 2025 at 3:33 PM
ICYMI: Chemotaxis as a driver in immune privilege.
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
buff.ly/Mwn8t1c
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
buff.ly/Mwn8t1c
Reposted
Reposted
‼️EXTRAORDINARY WORLD RECORD
Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m !
WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl
BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit)
Also crazy 46.1C Bunji 🇵🇰1469m asl
History is rewritten again
Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m !
WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl
BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit)
Also crazy 46.1C Bunji 🇵🇰1469m asl
History is rewritten again
July 5, 2025 at 3:37 PM
‼️EXTRAORDINARY WORLD RECORD
Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m !
WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl
BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit)
Also crazy 46.1C Bunji 🇵🇰1469m asl
History is rewritten again
Brutal 48.5C Chillas,PAKISTAN 🇵🇰 1250m !
WORLD RECORD OF HIGHEST TEMPERATURE ABOVE 1000M asl
BUT...Yesterday 49.3C Bafq IRAN 🇮🇷 altitude 999m (they should have moved the station a bit)
Also crazy 46.1C Bunji 🇵🇰1469m asl
History is rewritten again
Reposted
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
July 5, 2025 at 5:09 PM
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
Reposted
Hot day on the French Riviera:
With 37.4C Sete broke its record of July highest temperature on record.
With 37.4C Sete broke its record of July highest temperature on record.
July 5, 2025 at 6:09 PM
Hot day on the French Riviera:
With 37.4C Sete broke its record of July highest temperature on record.
With 37.4C Sete broke its record of July highest temperature on record.
Reposted
East Asia: The hell is coming.
Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C.
Records will be hundreds (at best)
Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C.
Records will be hundreds (at best)
July 5, 2025 at 9:08 PM
East Asia: The hell is coming.
Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C.
Records will be hundreds (at best)
Eastern China,The Koreas,Japan and parts of Far East Russia are gonna live hazardous conditions with temperatures up to 40C,up to 30C at night,extreme humidity and locally heat indexes >50C.
Records will be hundreds (at best)