Clinical outcome assessment (COA), particularly health-related quality of life (HRQoL) is an important component of patient-centered outcome assessmen…

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Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

Nature Reviews Neurology, Published online: 25 June 2025; doi:10.1038/s41582-025-01112-8Chimeric antigen receptor (CAR) T cells provide an effective treatment option for advanced haematological malignancies, but neurological adverse effects of CAR T cell therapies are common. This article reviews current knowledge regarding the mechanisms that contribute to neurological toxicities following CAR T cell therapy and highlights current and emerging management strategies.

Understanding the pathophysiology of hypoxic-ischemic encephalopathy (HIE) provides important knowledge for the interpretation of neuroprognostic inve…

Nature Reviews Neurology, Published online: 02 May 2025; doi:10.1038/s41582-025-01089-4In this Perspective, the authors provide a detailed description of rare autoimmune encephalitic conditions that present with recurrent seizures that are resistant to immunotherapy, grouped under the term autoimmune encephalitis-associated epilepsy. The article considers the clinical characteristics and pathophysiological mechanisms of these conditions, alongside current knowledge of treatment and outcomes.

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Status epilepticus represents a significant neurological emergency, with high morbidity and mortality rates. In addition to standard care, the identification of adjuvant strategies is essential to ...

Status epilepticus represents a significant neurological emergency, with high morbidity and mortality rates. In addition to standard care, the identification of adjuvant strategies is essential to ...