Srinjan Lab
@srinjan.bsky.social
Lecturer @imperiallifesci.bsky.social @imperialsci.bsky.social
@imperialcollegeldn.bsky.social |Unravelling DNA mysteries in stem cells by staring at little dots| #salsa dancer| he/him |
https://profiles.imperial.ac.uk/srinjan.basu
@imperialcollegeldn.bsky.social |Unravelling DNA mysteries in stem cells by staring at little dots| #salsa dancer| he/him |
https://profiles.imperial.ac.uk/srinjan.basu
Pinned
Srinjan Lab
@srinjan.bsky.social
· Feb 26
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Srinjan Lab
My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Pathway to Independence – an interview with Anzy Miller
Anzy Miller, former Sir Henry Wellcome Postdoctoral Fellow supported by Nancy Papalopulu (The University of Manchester, UK), is interested in the mechanisms involved in the generation of human pancrea...
journals.biologists.com
August 4, 2025 at 12:39 PM
My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Srinjan Lab
We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments
Introducing five concepts from dynamical systems to decode developmental regulatory mechanisms, have a read! @perez-carrasco.bsky.social @roederlab.bsky.social @mpipz.bsky.social This effort started in a morphogenesis meeting @kitp-ucsb.bsky.social in 2023. journals.biologists.com/dev/article/...
August 4, 2025 at 2:46 PM
We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments
Reposted by Srinjan Lab
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
July 10, 2025 at 4:21 AM
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
This Friday 27th June, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Daniela Dietrich joining us from Bristol and our very own Annabelle Wurmser from my lab. Please do join us!
June 24, 2025 at 2:08 PM
This Friday 27th June, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Daniela Dietrich joining us from Bristol and our very own Annabelle Wurmser from my lab. Please do join us!
Reposted by Srinjan Lab
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Postdoctoral Researcher
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...
elxw.fa.em3.oraclecloud.com
March 20, 2025 at 9:22 AM
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
Reposted by Srinjan Lab
📢 Don’t miss the first Cancer Biology and Medicine talk of 2025 tomorrow!
Cancer stem cells, evolution and heterogeneity
Prof Brian Huntley @scicambridge.bsky.social
Thurs 9 Jan, 9:30-10:30
TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social
All welcome!
Cancer stem cells, evolution and heterogeneity
Prof Brian Huntley @scicambridge.bsky.social
Thurs 9 Jan, 9:30-10:30
TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social
All welcome!
January 8, 2025 at 10:00 AM
📢 Don’t miss the first Cancer Biology and Medicine talk of 2025 tomorrow!
Cancer stem cells, evolution and heterogeneity
Prof Brian Huntley @scicambridge.bsky.social
Thurs 9 Jan, 9:30-10:30
TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social
All welcome!
Cancer stem cells, evolution and heterogeneity
Prof Brian Huntley @scicambridge.bsky.social
Thurs 9 Jan, 9:30-10:30
TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social
All welcome!
Reposted by Srinjan Lab
Happy holi, the festival of UMAPs
March 15, 2025 at 8:01 AM
Happy holi, the festival of UMAPs
Reposted by Srinjan Lab
Wanna learn what we know about why we need to sleep? Here's a fun podcast I recorded for the excellent @npr.org "Seeking a scientist" show, conducted by Kate the Chemist. Enjoy!
@imperiallifesci.bsky.social @imperialcollegeldn.bsky.social
www.kcur.org/podcast/seek...
@imperiallifesci.bsky.social @imperialcollegeldn.bsky.social
www.kcur.org/podcast/seek...
Why do we need to sleep?
Humans spend one-third of their life sleeping, yet the purpose and function behind this regular state of unconsciousness remains a biological mystery. Sleep researcher Giorgio Gilestro is trying to un...
www.kcur.org
February 26, 2025 at 4:20 PM
Wanna learn what we know about why we need to sleep? Here's a fun podcast I recorded for the excellent @npr.org "Seeking a scientist" show, conducted by Kate the Chemist. Enjoy!
@imperiallifesci.bsky.social @imperialcollegeldn.bsky.social
www.kcur.org/podcast/seek...
@imperiallifesci.bsky.social @imperialcollegeldn.bsky.social
www.kcur.org/podcast/seek...
Reposted by Srinjan Lab
Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!!
📅 Wed, 12 March 2025
Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease.
@doryenbubeck.bsky.social
#OurImperial
📅 Wed, 12 March 2025
Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease.
@doryenbubeck.bsky.social
#OurImperial
February 17, 2025 at 1:01 PM
Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!!
📅 Wed, 12 March 2025
Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease.
@doryenbubeck.bsky.social
#OurImperial
📅 Wed, 12 March 2025
Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease.
@doryenbubeck.bsky.social
#OurImperial
Reposted by Srinjan Lab
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
media.tenor.com
February 13, 2025 at 1:23 PM
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
Reposted by Srinjan Lab
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
CHD3 regulates BMP signalling response during cranial neural crest cell specification https://www.biorxiv.org/content/10.1101/2025.02.14.638260v1
February 15, 2025 at 7:55 AM
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 6:07 PM
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Next friday February 7th, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Ben Steventon joining us from Cambridge @bensteventon.bsky.social and our very own Floriane Tissot from the Lo Celso lab.
January 28, 2025 at 8:43 PM
Next friday February 7th, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Ben Steventon joining us from Cambridge @bensteventon.bsky.social and our very own Floriane Tissot from the Lo Celso lab.
Reposted by Srinjan Lab
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications
Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...
www.nature.com
January 27, 2025 at 2:49 PM
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Exciting stuff, congrats to all involved!
Exciting new preprint alert! 🚨 The Collepardo lab, teaming up with Huabin Zhou and the Rosen lab we took a deep, high-resolution look into chromatin condensates! [1/6] #Chromatin #MD @rcollepardo.bsky.social @juliamaristany.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
January 23, 2025 at 9:31 AM
Exciting stuff, congrats to all involved!
Reposted by Srinjan Lab
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
qmul-jobs.tal.net
January 21, 2025 at 9:33 AM
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Basu lab hosted their first department social today @imperiallifesci.bsky.social My lab put together this amazing cell of food alongside fun games like cell fate charades. So proud of our masters students who coordinated everything from start to finish!!
December 6, 2024 at 10:19 PM
Basu lab hosted their first department social today @imperiallifesci.bsky.social My lab put together this amazing cell of food alongside fun games like cell fate charades. So proud of our masters students who coordinated everything from start to finish!!
Reposted by Srinjan Lab
🚨Abstract deadline- 13th December! 🚨
Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed!
We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...
Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed!
We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...
November 25, 2024 at 9:13 PM
🚨Abstract deadline- 13th December! 🚨
Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed!
We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...
Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed!
We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...