Sebastián Palacios Martínez
@spalaciosm.bsky.social
PhD at the University of Amsterdam. Microscopy enthusiast 🔬, cytoskeleton admirer 🧫, hopeful sensor builder. Mostly just a biologist finding his way. Opinions my own.
I'm really late to the party, but it's sad to see edX, originally a non-profit that provided high-quality, free courses on specialized topics became for-profit Their content is now gatekept behind yet another subscription model.
Years later the new owners are in deep debt anyway:
Years later the new owners are in deep debt anyway:
Three years later, has the $800M edX deal lost its luster?
2U’s acquisition of online course provider edX was once seen as a major win—and potentially even larger disrupter—in the OPM industry. Things didn’t go as planned.
www.insidehighered.com
November 17, 2025 at 1:54 PM
I'm really late to the party, but it's sad to see edX, originally a non-profit that provided high-quality, free courses on specialized topics became for-profit Their content is now gatekept behind yet another subscription model.
Years later the new owners are in deep debt anyway:
Years later the new owners are in deep debt anyway:
Reposted by Sebastián Palacios Martínez
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology
go.nature.com/4p2hyua
go.nature.com/4p2hyua
How genetically encoded sensors have lit up neuroscience
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
go.nature.com
November 11, 2025 at 11:38 AM
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology
go.nature.com/4p2hyua
go.nature.com/4p2hyua
Reposted by Sebastián Palacios Martínez
Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
November 7, 2025 at 2:40 PM
Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...
Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social
Reposted by Sebastián Palacios Martínez
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
go.nature.com/47hn0n5
go.nature.com/47hn0n5
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
go.nature.com
November 1, 2025 at 5:39 PM
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
go.nature.com/47hn0n5
go.nature.com/47hn0n5
Reposted by Sebastián Palacios Martínez
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by Sebastián Palacios Martínez
A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.
buff.ly/WHU3w3s
buff.ly/WHU3w3s
October 22, 2025 at 10:02 AM
A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.
buff.ly/WHU3w3s
buff.ly/WHU3w3s
Reposted by Sebastián Palacios Martínez
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
These ancient bumblebees were found with their pollen source
Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.
www.sciencenews.org
October 15, 2025 at 6:22 PM
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
Can't wait to try this out!
FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single-cell fluorescence lifetime data by Rupsa Datta and team: www.biorxiv.org/content/10.1...
October 9, 2025 at 11:13 AM
Can't wait to try this out!
Reposted by Sebastián Palacios Martínez
I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
October 4, 2025 at 11:50 AM
I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
Reposted by Sebastián Palacios Martínez
Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91
go.nature.com/46K10ja
go.nature.com/46K10ja
Jane Goodall’s legacy: three ways she changed science
The primatologist challenged what it meant to be a scientist.
go.nature.com
October 2, 2025 at 9:38 AM
Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91
go.nature.com/46K10ja
go.nature.com/46K10ja
Reposted by Sebastián Palacios Martínez
I find that so many biologists are also talented artists.
@hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.
@hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.
October 1, 2025 at 9:05 AM
I find that so many biologists are also talented artists.
@hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.
@hsuanpai.bsky.social is a skilled technician and apparently good at any artistic media she touches.. even LB.
Reposted by Sebastián Palacios Martínez
My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it:
🧵
🧵
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable
lifetimes across the visible spectrum enables simultaneous multiplexed live imaging,
super-resolution microscopy, a...
www.cell.com
September 29, 2025 at 5:51 PM
My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it:
🧵
🧵
Reposted by Sebastián Palacios Martínez
Another #FluorescenceFriday, another movie of the cytoskeleton.
This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells!
LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/
This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells!
LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/
August 22, 2025 at 10:26 AM
Another #FluorescenceFriday, another movie of the cytoskeleton.
This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells!
LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/
This time around EB3-mScarlet3 and LifeAct-mStayGold co-expressed in U2Os cells!
LUTs here (Ink collection)--> sites.imagej.net/JDM_LUTs/luts/
Reposted by Sebastián Palacios Martínez
Today is National Lighthouse Day honoring the historical and cultural significance of lighthouses. I've posted this image before but have reprocessed it. It is the lighthouse at St. Marks Florida. #photography #landscape #EastCoastKin #bnw #blackandwhitephotography #infrared #fullspectrum #clouds
August 7, 2025 at 9:58 AM
Today is National Lighthouse Day honoring the historical and cultural significance of lighthouses. I've posted this image before but have reprocessed it. It is the lighthouse at St. Marks Florida. #photography #landscape #EastCoastKin #bnw #blackandwhitephotography #infrared #fullspectrum #clouds
Reposted by Sebastián Palacios Martínez
🐙 This Octopus shifts from deep to active rest while "dreaming" for #MicroscopyMonday. REM‑like sleep (color bursts and twitches) filmed in real time by Horst Obenhaus @octoscience.bsky.social, currently a 2025 Whitman Fellow at @mblscience.bsky.social. #NESM
#Octopus #Neuro #SleepScience #MBL
#Octopus #Neuro #SleepScience #MBL
July 21, 2025 at 11:53 AM
🐙 This Octopus shifts from deep to active rest while "dreaming" for #MicroscopyMonday. REM‑like sleep (color bursts and twitches) filmed in real time by Horst Obenhaus @octoscience.bsky.social, currently a 2025 Whitman Fellow at @mblscience.bsky.social. #NESM
#Octopus #Neuro #SleepScience #MBL
#Octopus #Neuro #SleepScience #MBL
Reposted by Sebastián Palacios Martínez
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
buff.ly/pMGXJVM
buff.ly/pMGXJVM
July 1, 2025 at 10:03 AM
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.
buff.ly/pMGXJVM
buff.ly/pMGXJVM
A very late #FluorescenceFriday.
Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!
Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!
June 28, 2025 at 5:27 PM
A very late #FluorescenceFriday.
Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!
Reposting one of my favorite timelapses from the past year: EB3-mScarlet3 in a HeLa cell, look at those microtubules grow!
Shout-out to The Phage Collection Project run by @fnobrega.bsky.social
You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance!
Check their website for more info ➡️ www.phage-collection.org
You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance!
Check their website for more info ➡️ www.phage-collection.org
ThePhageCollectionProject
www.phage-collection.org
June 28, 2025 at 4:44 PM
Shout-out to The Phage Collection Project run by @fnobrega.bsky.social
You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance!
Check their website for more info ➡️ www.phage-collection.org
You can order your very own samplng kit and help with the discovery of new phages to combat antibiotic resistance!
Check their website for more info ➡️ www.phage-collection.org
Proud to work with and learn from an extraordinary biologist 🔬
This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social
@joachimgoedhart.bsky.social
June 25, 2025 at 4:13 PM
Proud to work with and learn from an extraordinary biologist 🔬
Reposted by Sebastián Palacios Martínez
Great nod to the photography work of Bernd and Hilla Becher
June 22, 2025 at 7:19 AM
Great nod to the photography work of Bernd and Hilla Becher
Reposted by Sebastián Palacios Martínez
Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance
😍
Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...
😍
Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...
June 20, 2025 at 7:06 PM
Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance
😍
Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...
😍
Jaap van Buul Lab @jcellsci.bsky.social 2025
journals.biologists.com/jcs/article-...
Reposted by Sebastián Palacios Martínez
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
March 20, 2025 at 1:31 PM
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
Reposted by Sebastián Palacios Martínez
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
www.biorxiv.org
March 10, 2025 at 3:36 AM
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sebastián Palacios Martínez
I had to try this (see preprint), so here's a result with milk ± ampyrone and it just works!!
March 7, 2025 at 6:51 PM
I had to try this (see preprint), so here's a result with milk ± ampyrone and it just works!!