Thanks to all who attended the 2025 Angelika Amon Young Scientist Award ceremony. The award honors exceptional graduate work done outside the US & brings winners to the KI to share their science. Congrats to Sourav Ghosh & Kotaro Tomuro on engaging talks. mit-ki.org/46zzJB5

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

So grateful to the AIC team at Janelia! Three surreal weeks packed with months of learning, cutting-edge technology, and inspiring science. Huge thanks to Bob’s for the amazing food—it made everything even sweeter. Truly an experience of a lifetime that I’ll always cherish! 💛
#microscopy #IPALM #ExM

Incredibly honoured and grateful to receive the 2025 Angelika Amon Young Scientist Award! Deep thanks to my supervisor @anirban-banerjee.bsky.social, friends, lab colleagues, Department of Biosciences and Bioengineering, and @iitbombay.bsky.social for their unwavering support. Simply Lovely.

NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study.
www.nature.com/articles/s41...
@ivahb.bsky.social @elvirab.bsky.social

Tick Tock Neutrophil Clock

Hall Lab (Auckland) with zebrafish model find light boosts the circadian protein Per2, which enhances ROS and hmgb1a expression via a BMAL1–NF-κB enhancer

End result: Better bacterial clearance and survival—a circadian clock-gated boost for daytime innate immune function

Cool insights.

If you're into host-pathogen interactions and cell-autonomous immunity, this is a must-attend! Stellar speaker lineup and exciting science all around. Also, catch work from our lab being presented!"
#immunity #conference #india #embo

Haven’t shared this in a while. But the #ubiquitin and #ubl Starter Pack now includes 116 profiles to follow if you’re interested in the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

Great to see this out. A story that spanned continents, cities and budget codes…

www.nature.com/articles/s41...

Big thanks to all the teams involved!

@clausenlab.bsky.social @e3chembio.bsky.social

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

We can see our ECR-focused LINE symposium already on the horizon (9th of June) @crick.ac.uk. shorturl.at/MyWNl 🥳
You can submit your abstracts (talk or poster) until the EXTENDED DEADLINE on the 12th of May here: shorturl.at/7KuXL
Free registration shorturl.at/wLyWY
We're excited to see you there!

RNF213, a host E3 ligase, ubiquitylates LPS to mark cytosol-invading bacteria for autophagy. But how do cytosol-adapted bacteria escape? We found that Shigella's E3 ligase IpaH1.4 blocks LPS ubiquitylation by degrading RNF213 via the proteasome.
www.nature.com/articles/s41...

Amazing analogy. Thank you for sharing.

🚨Got a few minutes over breakfast? 🥣
Here’s a quick peek at what we’ve been up to.
If you don’t have time for the full paper, this summary’s got the essence.
Hope you find it as exciting! 🦠🔬 @natmicrobiol.nature.com @springernature.com
#sciencecom

communities.springernature.com/posts/rippin...

Happy to share my Ph.D work!!
Our latest paper shows VCP/p97 uses its tweezer-like action to tear invading bacteria apart — a powerful cellular defense! 🦠
@natmicrobiol.nature.com
@BsbeIitb @iitbombay @CSIR
This was years of hard work! Thanks all🙌
#microbiology #cellautonomous #immunity #ubiquitin