Susan Lea
@smlea.bsky.social
Scientist at St Jude using structural biology to try and understand how things work - views are my own not my institutions
Reposted by Susan Lea
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
doi.org
October 2, 2025 at 6:20 AM
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Susan Lea
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress - Nature Communications
Actinobacteria grow by inserting new cell wall material at the cell poles. Here, Zhong et al. show that a stomatin-like protein modulates polar growth under hyperosmotic stress by facilitating the for...
www.nature.com
March 18, 2025 at 6:27 PM
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
Reposted by Susan Lea
Reposted by Susan Lea
Last few days to apply for this:
There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
March 7, 2025 at 1:33 PM
Last few days to apply for this:
Reposted by Susan Lea
Less than half an hour ago, a peaceful transfer of power has taken place at #BPS2025!
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
February 18, 2025 at 5:44 PM
Less than half an hour ago, a peaceful transfer of power has taken place at #BPS2025!
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Reposted by Susan Lea
A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota https://www.biorxiv.org/content/10.1101/2025.02.17.638638v1
February 18, 2025 at 2:17 AM
A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota https://www.biorxiv.org/content/10.1101/2025.02.17.638638v1
Reposted by Susan Lea
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
January 26, 2025 at 1:30 PM
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
Reposted by Susan Lea
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out
January 26, 2025 at 12:27 PM
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out
Reposted by Susan Lea
Hive mind:
I seem to remember having seen a plot/analysis showing that pLDDT is correlated to conservation but my mind or Google-fu isn’t finding it
I seem to remember having seen a plot/analysis showing that pLDDT is correlated to conservation but my mind or Google-fu isn’t finding it
January 17, 2025 at 9:49 PM
Hive mind:
I seem to remember having seen a plot/analysis showing that pLDDT is correlated to conservation but my mind or Google-fu isn’t finding it
I seem to remember having seen a plot/analysis showing that pLDDT is correlated to conservation but my mind or Google-fu isn’t finding it
Reposted by Susan Lea
It is a great honour to invite you to a symposium to celebrate the career of Mark Carrington. An exciting set of talks, particularly if you are fascinated by trypanosomes.
January 13, 2025 at 10:32 AM
It is a great honour to invite you to a symposium to celebrate the career of Mark Carrington. An exciting set of talks, particularly if you are fascinated by trypanosomes.
Reposted by Susan Lea
1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!
December 17, 2024 at 7:27 PM
1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!
Reposted by Susan Lea
19F modified amino acids such as trifluoromethyl-Phe integrated into proteins can give strong, clean signals for complex samples, but the results are difficult to interpret in terms of structure
This study uses "ring current design" to increase 19F chemical shift dispersion and interpretability 🧬🧶🧲
This study uses "ring current design" to increase 19F chemical shift dispersion and interpretability 🧬🧶🧲
Out now! How to rationally design 19F labels to study structures of large biomol complexes, incl in cells. Using engineered ring currents, and designed with MD and AF.
With co-first author Julian Streit, and Saifu Daya and John Christodoulou.
#nmrchat #compchem
www.biorxiv.org/content/10.1...
With co-first author Julian Streit, and Saifu Daya and John Christodoulou.
#nmrchat #compchem
www.biorxiv.org/content/10.1...
Rational design of 19F NMR labelling sites to probe protein structure and interactions
Proteins are investigated in increasingly more complex biological systems, where 19F NMR is proving highly advantageous due to its high gyromagnetic ratio and background-free spectra. Its application ...
www.biorxiv.org
December 17, 2024 at 9:55 PM
19F modified amino acids such as trifluoromethyl-Phe integrated into proteins can give strong, clean signals for complex samples, but the results are difficult to interpret in terms of structure
This study uses "ring current design" to increase 19F chemical shift dispersion and interpretability 🧬🧶🧲
This study uses "ring current design" to increase 19F chemical shift dispersion and interpretability 🧬🧶🧲
Reposted by Susan Lea
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
December 9, 2024 at 4:36 PM
Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990
Reposted by Susan Lea
Clap in the face reminder when judged on PhD/post doc years even after >12 years:
"Kovacs' record in microbiology is somewhat lighter, particularly early career lack of first-authored leadership on high level publications"
... and I am still in academic science #nevertheless
"Kovacs' record in microbiology is somewhat lighter, particularly early career lack of first-authored leadership on high level publications"
... and I am still in academic science #nevertheless
November 24, 2024 at 1:06 PM
Clap in the face reminder when judged on PhD/post doc years even after >12 years:
"Kovacs' record in microbiology is somewhat lighter, particularly early career lack of first-authored leadership on high level publications"
... and I am still in academic science #nevertheless
"Kovacs' record in microbiology is somewhat lighter, particularly early career lack of first-authored leadership on high level publications"
... and I am still in academic science #nevertheless
Reposted by Susan Lea
You may recall, we used a similar technique to find plasmid-dependent phages, by putting the same plasmid in two different bacteria. Now we do it for all sorts of phages!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diverse and abundant phages exploit conjugative plasmids - Nature Communications
Some phages use plasmid-encoded conjugation proteins as receptors to infect their bacterial hosts, making their host range dependent on horizontal transfer of the plasmid. Here, the authors present a ...
www.nature.com
November 23, 2024 at 6:42 PM
You may recall, we used a similar technique to find plasmid-dependent phages, by putting the same plasmid in two different bacteria. Now we do it for all sorts of phages!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Susan Lea
Phages! At the Disco!
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
November 23, 2024 at 6:34 PM
Phages! At the Disco!
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Reposted by Susan Lea
Visiting @arianebriegel.bsky.social at the Institute Pasteur ! Great to see her new lab!
November 22, 2024 at 8:40 AM
Visiting @arianebriegel.bsky.social at the Institute Pasteur ! Great to see her new lab!
Reposted by Susan Lea
We will be hosting 3rd Full Circle Symposium for Native Biologists hosted at UCSF in April 2025! We aim to build community and provide meaningful opportunities for Native scientists. If you are a Native biologist who is interested plz fill this out to stay up to date: forms.gle/AN7nfkhdB3Fv...
November 18, 2024 at 8:06 PM
We will be hosting 3rd Full Circle Symposium for Native Biologists hosted at UCSF in April 2025! We aim to build community and provide meaningful opportunities for Native scientists. If you are a Native biologist who is interested plz fill this out to stay up to date: forms.gle/AN7nfkhdB3Fv...
Reposted by Susan Lea
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
November 18, 2024 at 3:09 PM
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
Reposted by Susan Lea
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
Published today Steve and Justin’s story that finally reveals the basis for transmission of uni directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s415...
March 8, 2024 at 1:11 PM
Published today Steve and Justin’s story that finally reveals the basis for transmission of uni directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s415...
Reposted by Susan Lea
Important so please help spread the word...
Interested in postgrad research? Maybe do a PhD?
Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds
Stipend, free accommodation, mentoring...
Deadline 21 Feb
www.ox.ac.uk/admissions/g...
Interested in postgrad research? Maybe do a PhD?
Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds
Stipend, free accommodation, mentoring...
Deadline 21 Feb
www.ox.ac.uk/admissions/g...
January 15, 2024 at 5:29 PM
Important so please help spread the word...
Interested in postgrad research? Maybe do a PhD?
Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds
Stipend, free accommodation, mentoring...
Deadline 21 Feb
www.ox.ac.uk/admissions/g...
Interested in postgrad research? Maybe do a PhD?
Oxford runs a summer internship scheme for UK students from under-represented and disadvantaged backgrounds
Stipend, free accommodation, mentoring...
Deadline 21 Feb
www.ox.ac.uk/admissions/g...
Time for puppy to start sciencing….
January 4, 2024 at 4:08 PM
Time for puppy to start sciencing….
Reposted by Susan Lea
For microbiologists seeking faculty jobs: Rutgers has 4+ faculty searches in microbiology right now! Please share widely and see below for details and links on the individual positions 1/5
November 14, 2023 at 11:37 PM
For microbiologists seeking faculty jobs: Rutgers has 4+ faculty searches in microbiology right now! Please share widely and see below for details and links on the individual positions 1/5
Reposted by Susan Lea
A fantastic postdoc opportunity with Jon Grimes at Strubi, University of Oxford, to study the molecular mechanisms of viruses using the latest cryo-ET and cryo-SIM technologies.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
November 7, 2023 at 4:43 PM
A fantastic postdoc opportunity with Jon Grimes at Strubi, University of Oxford, to study the molecular mechanisms of viruses using the latest cryo-ET and cryo-SIM technologies.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...