Susan Lea
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smlea.bsky.social
Susan Lea
@smlea.bsky.social
Scientist at St Jude using structural biology to try and understand how things work - views are my own not my institutions
Reposted by Susan Lea
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.

doi.org/10.1038/s415...
A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
doi.org
October 2, 2025 at 6:20 AM
Reposted by Susan Lea
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
January 26, 2025 at 1:30 PM
Always amazes me that numerate folks can’t see that if one Prof has multiple trainees in their group over a career you need expansion of the sector for more than one trainee to become a Prof…and massive expansion for even 60% to stay in academia…we have to be training them for non-academic careers!
January 26, 2025 at 12:58 PM
Reposted by Susan Lea
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out
January 26, 2025 at 12:27 PM
As a structural biologist the only sensible hypothesis is - if I see what it looks like I’ll understand it better…
December 6, 2024 at 8:13 PM
Ben Barres was a wonderful person and his insights were incredibly important for highlighting structural issues - but I feel uncomfortable that this is another example of a man’s views having more weight. Why does it take a male presenting person (be they ally or transgender) to get our voice heard?
November 25, 2024 at 12:39 PM
The year I was elected to EMBO the news of that came through followed a couple of weeks later by a stage one rejection from the ERC…essentially the ‘we haven’t heard of her’ stage of evaluation…best thing was it meant I was blocked from reapplying so didn’t have to write another for a while…
November 24, 2024 at 2:03 PM
Reposted by Susan Lea
You may recall, we used a similar technique to find plasmid-dependent phages, by putting the same plasmid in two different bacteria. Now we do it for all sorts of phages!
www.nature.com/articles/s41...
Diverse and abundant phages exploit conjugative plasmids - Nature Communications
Some phages use plasmid-encoded conjugation proteins as receptors to infect their bacterial hosts, making their host range dependent on horizontal transfer of the plasmid. Here, the authors present a ...
www.nature.com
November 23, 2024 at 6:42 PM
Meet Dante - he wants me to tell you he’s a very good boy ;-)
November 13, 2024 at 8:57 PM