@sliverdaemon.bsky.social
"Then how should I begin
To spit out all the butt-ends of my days and ways?
And how should I presume?" - TS Eliot, Love Song of J. Alfred Prufrock
I like ML, quantitive biology, and medicine.
To spit out all the butt-ends of my days and ways?
And how should I presume?" - TS Eliot, Love Song of J. Alfred Prufrock
I like ML, quantitive biology, and medicine.
thought is a miracle
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The brain fires up immune cells when sick people are nearby
When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.
www.nature.com
July 30, 2025 at 2:41 AM
thought is a miracle
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted
Bacteria from a Yellowstone hot spring do something no other organism has been found to do: breathe oxygen and sulfur at the same time. 🧪 It's both aerobic and anaerobic, a beautiful freaky creature from a beautiful freaky place
The Cells That Breathe Two Ways | Quanta Magazine
In a hot spring at Yellowstone National Park, a microbe does something that life shouldn’t be able to do: It breathes oxygen and sulfur at the same time.
www.quantamagazine.org
July 28, 2025 at 12:49 PM
Bacteria from a Yellowstone hot spring do something no other organism has been found to do: breathe oxygen and sulfur at the same time. 🧪 It's both aerobic and anaerobic, a beautiful freaky creature from a beautiful freaky place
Reposted
🐌💫 Snail embryos never looked so fabulous!
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
July 25, 2025 at 11:11 PM
🐌💫 Snail embryos never looked so fabulous!
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
whole genome doubling is common in cancers, below you can see how that manifests in single cell transcriptomics (of ovarian cancer)
Nature research paper: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
go.nature.com/40qLLcJ
go.nature.com/40qLLcJ
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disrupts immunity.
go.nature.com
July 22, 2025 at 2:23 AM
whole genome doubling is common in cancers, below you can see how that manifests in single cell transcriptomics (of ovarian cancer)
Reposted
Aceitón, Riobó, Del Valle Batalla, Yuseff et al show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation rupress.org/jcb/article/...
July 21, 2025 at 5:15 PM
Aceitón, Riobó, Del Valle Batalla, Yuseff et al show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation rupress.org/jcb/article/...
Reposted
Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
July 21, 2025 at 12:52 PM
Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...
Reposted
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
July 3, 2025 at 2:23 PM
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
what a time to be alive! (you know, as far image processing is concerned)
New in #biabob 0.29.0: Code insertions in @jupyter.org Cells! 🥳
If you know how to start your image analysis, and how to visualize the results, just put %bob in between and let the AI do the hard coding work. Also provide hints as comments to guide the AI 😉
github.com/haesleinhuep...
If you know how to start your image analysis, and how to visualize the results, just put %bob in between and let the AI do the hard coding work. Also provide hints as comments to guide the AI 😉
github.com/haesleinhuep...
July 3, 2025 at 12:28 PM
what a time to be alive! (you know, as far image processing is concerned)
dogma now absurd first
When science advances:
"... 𝘢𝘵 𝘵𝘩𝘢𝘵 𝘵𝘪𝘮𝘦, 𝘯𝘰𝘣𝘰𝘥𝘺 𝘤𝘰𝘶𝘭𝘥 𝘪𝘮𝘢𝘨𝘪𝘯𝘦 𝘵𝘩𝘢𝘵 𝘵𝘩𝘦 𝘱𝘩𝘰𝘴𝘱𝘩𝘰𝘳𝘺𝘭𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘢𝘯 𝘦𝘯𝘻𝘺𝘮𝘦 𝘤𝘰𝘶𝘭𝘥 𝘣𝘦 𝘪𝘯𝘷𝘰𝘭𝘷𝘦𝘥 𝘪𝘯 𝘪𝘵𝘴 𝘳𝘦𝘨𝘶𝘭𝘢𝘵𝘪𝘰𝘯."
-- Eddy Fischer
Nobel Prize in Physiology or Medicine 1992
"... 𝘢𝘵 𝘵𝘩𝘢𝘵 𝘵𝘪𝘮𝘦, 𝘯𝘰𝘣𝘰𝘥𝘺 𝘤𝘰𝘶𝘭𝘥 𝘪𝘮𝘢𝘨𝘪𝘯𝘦 𝘵𝘩𝘢𝘵 𝘵𝘩𝘦 𝘱𝘩𝘰𝘴𝘱𝘩𝘰𝘳𝘺𝘭𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘢𝘯 𝘦𝘯𝘻𝘺𝘮𝘦 𝘤𝘰𝘶𝘭𝘥 𝘣𝘦 𝘪𝘯𝘷𝘰𝘭𝘷𝘦𝘥 𝘪𝘯 𝘪𝘵𝘴 𝘳𝘦𝘨𝘶𝘭𝘢𝘵𝘪𝘰𝘯."
-- Eddy Fischer
Nobel Prize in Physiology or Medicine 1992
July 2, 2025 at 9:26 PM
dogma now absurd first
Reposted
I am once again reminded of my favorite @edyong209.bsky.social quote:
“…a tiny wise decision can do exponential good.”
“…a tiny wise decision can do exponential good.”
June 28, 2025 at 4:09 PM
I am once again reminded of my favorite @edyong209.bsky.social quote:
“…a tiny wise decision can do exponential good.”
“…a tiny wise decision can do exponential good.”
Reposted
Queequeq, my fine friend, does this sort of thing often happen?
June 28, 2025 at 4:47 PM
Queequeq, my fine friend, does this sort of thing often happen?
Reposted
Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance
www.science.org/cont...
www.science.org/cont...
Always ‘one atom away’: The long, rocky journey to an HIV prevention breakthrough
Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance
www.science.org
June 28, 2025 at 6:22 PM
Developing lenacapavir, the drug newly approved to protect against HIV for six months in one shot, took basic science, sophisticated chemistry, and perseverance
www.science.org/cont...
www.science.org/cont...
Reposted
The inferno of the living is not something that will be; if there is one, it is what is already here, the inferno where we live every day, that we form by being together. There are two ways to escape suffering it.
1/3
1/3
June 26, 2025 at 12:19 PM
The inferno of the living is not something that will be; if there is one, it is what is already here, the inferno where we live every day, that we form by being together. There are two ways to escape suffering it.
1/3
1/3
June 27, 2025 at 2:21 AM
Reposted
Meet The Speakers of the Single-Cell Approaches in Plant Biology GRC Conference!
To Apply to the GRC: lnkd.in/gvkMxuKR
To Learn More About Dr. Shahan's Research: sites.lifesci.ucla.edu/mcdb-shahan/
@rachelmshahan.bsky.social
To Apply to the GRC: lnkd.in/gvkMxuKR
To Learn More About Dr. Shahan's Research: sites.lifesci.ucla.edu/mcdb-shahan/
@rachelmshahan.bsky.social
June 26, 2025 at 7:33 PM
Meet The Speakers of the Single-Cell Approaches in Plant Biology GRC Conference!
To Apply to the GRC: lnkd.in/gvkMxuKR
To Learn More About Dr. Shahan's Research: sites.lifesci.ucla.edu/mcdb-shahan/
@rachelmshahan.bsky.social
To Apply to the GRC: lnkd.in/gvkMxuKR
To Learn More About Dr. Shahan's Research: sites.lifesci.ucla.edu/mcdb-shahan/
@rachelmshahan.bsky.social
Reposted
If we can develop cheap, effective and stable inoculants... Effect of Arbuscular Mycorrhyzal Fungi in Improving Soybean Growth in Ultisol Soil | Applied Research in Science and Technology
Effect of Arbuscular Mycorrhyzal Fungi in Improving Soybean Growth in Ultisol Soil
Background: Soybean is one of the most popular agricultural commodities in Indonesia, but its production is still low. Thus, it is necessary to make efforts to expand its agriculture in the form of marginal land development.
Aims: This study aims to examine the effect and obtain the best treatment dose of arbuscular mycorrhizal fungi (AMF) in ultisol soil to increase the growth of soybean plants (Glycine max (L.) Merill).
Methods: This experimental study employed a complete randomized design (CRD) with the treatment of arbuscular mycorrhizal fungi (AMF). The AMF treatment comprised five levels: no AMF, 4 g/polibag, 8 g/polibag, 12 g/polibag and 16 g/polibag. Each treatment was repeated four times, resulting in 20 experimental units and each experimental unit comprised three polybags so that this study used 60 polybags. The data were analyzed using Analysis of Variance (ANOVA) and continued with Duncan's New Multiple Range Test (DNMRT) at the 5% level.
Result: AMF treatment is able to increase the growth of soybean plants in the parameters of plant height, number of productive branches, flowering age, number of flowers, and harvest age. The AMF treatment dose of 12 g/polybag is proven to give the best results in increasing the growth of soybean plants. The use of AMF can be an effective strategy in optimizing soybean production, especially on marginal lands.
sco.lt
June 25, 2025 at 9:58 PM
If we can develop cheap, effective and stable inoculants... Effect of Arbuscular Mycorrhyzal Fungi in Improving Soybean Growth in Ultisol Soil | Applied Research in Science and Technology
Reposted
If we trust genetic engineering to save a child from leukemia, why reject it when it could save a child from blindness, malnutrition, or death?
We cure cancer with genetic engineering but ban it on the farm.
Celebrating one but demonizing the other fuels disinformation that costs lives.
1/
We cure cancer with genetic engineering but ban it on the farm.
Celebrating one but demonizing the other fuels disinformation that costs lives.
1/
June 24, 2025 at 10:26 PM
If we trust genetic engineering to save a child from leukemia, why reject it when it could save a child from blindness, malnutrition, or death?
We cure cancer with genetic engineering but ban it on the farm.
Celebrating one but demonizing the other fuels disinformation that costs lives.
1/
We cure cancer with genetic engineering but ban it on the farm.
Celebrating one but demonizing the other fuels disinformation that costs lives.
1/
I've seen this disease firsthand; believe me when I say this is an incredibly important moment for those who have EB. Bravo Stanford!
Stanford Medicine researchers have used gene-edited skin grafts—made from patients’ own cells—to heal painful, chronic wounds caused by epidermolysis bullosa.
stan.md/3HNC7KO
stan.md/3HNC7KO
June 24, 2025 at 12:33 AM
I've seen this disease firsthand; believe me when I say this is an incredibly important moment for those who have EB. Bravo Stanford!
"cells grow long signaling filopodia called cytonemes [...] visible extending from the orange cell"
Happy #FluorescenceFriday! These are cultured fibroblasts imaged on a confocal microscope by postdoc Christina Daly. She is trying to understand how cells grow long signaling filopodia called cytonemes. Examples are visible extending from the orange cell in the image. 🤩 🧪 👩🔬
June 22, 2025 at 10:50 PM
"cells grow long signaling filopodia called cytonemes [...] visible extending from the orange cell"
Reposted
Explore Wikipedia through a data map. Pages are grouped by semantic similarity, for topic clusters.
Hover to see details, zoom to explore more fine-grained topics, click to go to a page. Search by page
name to find interesting starting points for exploration.
lmcinnes.github.io/datamapplot_...
Hover to see details, zoom to explore more fine-grained topics, click to go to a page. Search by page
name to find interesting starting points for exploration.
lmcinnes.github.io/datamapplot_...
June 22, 2025 at 3:36 PM
Explore Wikipedia through a data map. Pages are grouped by semantic similarity, for topic clusters.
Hover to see details, zoom to explore more fine-grained topics, click to go to a page. Search by page
name to find interesting starting points for exploration.
lmcinnes.github.io/datamapplot_...
Hover to see details, zoom to explore more fine-grained topics, click to go to a page. Search by page
name to find interesting starting points for exploration.
lmcinnes.github.io/datamapplot_...
Reposted
For today's #FluorescenceFriday I'm thrilled to share that
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
June 20, 2025 at 4:58 PM
For today's #FluorescenceFriday I'm thrilled to share that
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
ScienceAdvances was so nice to pick my picture as this week's featured image!
It's actually a still of a video😊
Check out the paper to learn more
science.org/doi/10.1126/...
#cellbio #devbio #cellmigration #science
Thank you @aaas.org
Reposted
Spectacular work by @maikbischoff.bsky.social @peiferlabunc.bsky.social showing how Plexin/Semaphorin-guided collective cell migration of muscle precursor cells shapes the developing testis. Look at the movies! 😱
| Science Advances www.science.org/doi/10.1126/...
| Science Advances www.science.org/doi/10.1126/...
Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance
An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.
www.science.org
June 19, 2025 at 10:06 AM
Spectacular work by @maikbischoff.bsky.social @peiferlabunc.bsky.social showing how Plexin/Semaphorin-guided collective cell migration of muscle precursor cells shapes the developing testis. Look at the movies! 😱
| Science Advances www.science.org/doi/10.1126/...
| Science Advances www.science.org/doi/10.1126/...
Reposted
Final version of this paper with Alexis Pietak (allencenter.tufts.edu/our-team/ale..., www.researchgate.net/profile/Alex...) is now out:
www.sciencedirect.com/science/arti...
"Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine"
www.sciencedirect.com/science/arti...
"Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine"
Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine
Gene regulatory networks (GRNs) are critically important for efforts in biomedicine and biotechnology. Here, we introduce the Regulatory Network Machi…
www.sciencedirect.com
June 17, 2025 at 7:28 PM
Final version of this paper with Alexis Pietak (allencenter.tufts.edu/our-team/ale..., www.researchgate.net/profile/Alex...) is now out:
www.sciencedirect.com/science/arti...
"Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine"
www.sciencedirect.com/science/arti...
"Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine"
June 16, 2025 at 5:42 PM
Reposted
Machine learning often performs unexpectedly poorly when deployed in real-world domains.
This article suggests that underspecification is a key reason for the poor performance.
This article suggests that underspecification is a key reason for the poor performance.
June 15, 2025 at 12:58 PM
Machine learning often performs unexpectedly poorly when deployed in real-world domains.
This article suggests that underspecification is a key reason for the poor performance.
This article suggests that underspecification is a key reason for the poor performance.