Satoshi Koyama
@skoyama.bsky.social
Assist. Director of Bioinformatics | MGB Personalized Medicine
Investigator, Cardiovascular Research Center | Massachusetts General Hospital Member of the Faculty | Harvard Medical School
Interested in Cardiovascular Genetics and Personalized Medicine 🧬👨💻
Investigator, Cardiovascular Research Center | Massachusetts General Hospital Member of the Faculty | Harvard Medical School
Interested in Cardiovascular Genetics and Personalized Medicine 🧬👨💻
Pinned
Satoshi Koyama
@skoyama.bsky.social
· Jan 15
Genetic Predisposition to LDL-C and Incident Type 2 Diabetes
This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholest...
jamanetwork.com
We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
Heading to #ASHG2025 ✈️🚢🚎?
We’ll present the latest CAD GWAS updates from CARDIoGRAMplusC4D (cardiogramplusc4d.xn--org)would-389d love to see you there!
📅 Saturday, Oct 18, 9:15–9:30 AM ET
📍 Room 253ABC (Level 2)
We’ll present the latest CAD GWAS updates from CARDIoGRAMplusC4D (cardiogramplusc4d.xn--org)would-389d love to see you there!
📅 Saturday, Oct 18, 9:15–9:30 AM ET
📍 Room 253ABC (Level 2)
October 10, 2025 at 1:47 PM
Heading to #ASHG2025 ✈️🚢🚎?
We’ll present the latest CAD GWAS updates from CARDIoGRAMplusC4D (cardiogramplusc4d.xn--org)would-389d love to see you there!
📅 Saturday, Oct 18, 9:15–9:30 AM ET
📍 Room 253ABC (Level 2)
We’ll present the latest CAD GWAS updates from CARDIoGRAMplusC4D (cardiogramplusc4d.xn--org)would-389d love to see you there!
📅 Saturday, Oct 18, 9:15–9:30 AM ET
📍 Room 253ABC (Level 2)
Reposted by Satoshi Koyama
I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.
I did this last year and it was great to meet a whole bunch of new people, at all career stages!
I did this last year and it was great to meet a whole bunch of new people, at all career stages!
October 6, 2025 at 11:14 PM
I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.
I did this last year and it was great to meet a whole bunch of new people, at all career stages!
I did this last year and it was great to meet a whole bunch of new people, at all career stages!
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
October 2, 2025 at 12:57 AM
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
Reposted by Satoshi Koyama
Reposted by Satoshi Koyama
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
July 28, 2025 at 10:58 AM
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
Reposted by Satoshi Koyama
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 2:00 PM
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Reposted by Satoshi Koyama
This is the best article I’ve read so far in terms of describing the challenges impacting research in the US.
I am being directly affected already. My RO1 is due to be reviewed on Monday but the study section is likely to be canceled. This will have a profound impact on our lab’s work #kidneyomics
I am being directly affected already. My RO1 is due to be reviewed on Monday but the study section is likely to be canceled. This will have a profound impact on our lab’s work #kidneyomics
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
www.npr.org
February 23, 2025 at 1:54 AM
This is the best article I’ve read so far in terms of describing the challenges impacting research in the US.
I am being directly affected already. My RO1 is due to be reviewed on Monday but the study section is likely to be canceled. This will have a profound impact on our lab’s work #kidneyomics
I am being directly affected already. My RO1 is due to be reviewed on Monday but the study section is likely to be canceled. This will have a profound impact on our lab’s work #kidneyomics
Reposted by Satoshi Koyama
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Satoshi Koyama
📹🍿🧬 Check out @yunfeng-ruan.bsky.social's recent talk at the @broadinstitute.org, "Polygenic risk scores: method development and application" in our growing collection of videos on the @prsdiversity.bsky.social website primedconsortium.org/education#vi...
Education | PRIMED Consortium
primedconsortium.org
February 3, 2025 at 11:41 PM
📹🍿🧬 Check out @yunfeng-ruan.bsky.social's recent talk at the @broadinstitute.org, "Polygenic risk scores: method development and application" in our growing collection of videos on the @prsdiversity.bsky.social website primedconsortium.org/education#vi...
Huge congrats! Satoshi😀
📣Excited to share our paper in Nature Genetics!
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
rdcu.be/d7mo0
Do plasma proteins mediate obesity’s effect on CAD risk?
→Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target.
A 🧵↓
January 24, 2025 at 2:25 PM
Huge congrats! Satoshi😀
We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
Genetic Predisposition to LDL-C and Incident Type 2 Diabetes
This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholest...
jamanetwork.com
January 15, 2025 at 7:15 PM
We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
x.com/akshayaravi22 🎉
jamanetwork.com/journals/jam...
Reposted by Satoshi Koyama
📣 APPLICATIONS ARE NOW OPEN for the 2025 Human Genetics and Genomics Gordon Research Conference and Seminar.
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
Join us in Portland, Maine for compelling and exciting discussions related to human genetics and genomics!! 🧬
www.grc.org/human-geneti...
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
Join us in Portland, Maine for compelling and exciting discussions related to human genetics and genomics!! 🧬
www.grc.org/human-geneti...
2025 Human Genetics and Genomics (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Human Genetics and Genomics (GRS) will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
December 4, 2024 at 4:42 PM
📣 APPLICATIONS ARE NOW OPEN for the 2025 Human Genetics and Genomics Gordon Research Conference and Seminar.
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
Join us in Portland, Maine for compelling and exciting discussions related to human genetics and genomics!! 🧬
www.grc.org/human-geneti...
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
Join us in Portland, Maine for compelling and exciting discussions related to human genetics and genomics!! 🧬
www.grc.org/human-geneti...
Reposted by Satoshi Koyama
Applications are now OPEN for the 2025 Human Genetics and Genomics GRC and GRS!! 🎉 🧬
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
📍 Portland, Maine
@calliao.bsky.social and I are co-chairs for the GRS, with Shamil Sunyaev and @eimearekenny.bsky.social as the GRC chairs 👀
Links to apply below 👇
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
📍 Portland, Maine
@calliao.bsky.social and I are co-chairs for the GRS, with Shamil Sunyaev and @eimearekenny.bsky.social as the GRC chairs 👀
Links to apply below 👇
December 4, 2024 at 4:42 PM
Applications are now OPEN for the 2025 Human Genetics and Genomics GRC and GRS!! 🎉 🧬
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
📍 Portland, Maine
@calliao.bsky.social and I are co-chairs for the GRS, with Shamil Sunyaev and @eimearekenny.bsky.social as the GRC chairs 👀
Links to apply below 👇
📅 GRS: July 5-6, 2025
📅 GRC: July 6-11, 2025
📍 Portland, Maine
@calliao.bsky.social and I are co-chairs for the GRS, with Shamil Sunyaev and @eimearekenny.bsky.social as the GRC chairs 👀
Links to apply below 👇