Shravan Kumar Kannan
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shravankk.bsky.social
Shravan Kumar Kannan
@shravankk.bsky.social
Immunology PhD student (@UIowa) in the Badovinac lab studying the mechanisms of naive and memory CD4 T cell dysfunction during Whole-body Irradiation and sepsis to develop and time effective medical interventions.

G-scholar: https://tinyurl.com/yc54acy5
I'm thrilled to share groundbreaking new research from John T. Harty's lab, spearheaded by Maddison Mix. This study reveals how peripheral microbial exposure in mice can boost memory T cell presence in the brain, significantly impacting neurological disease outcomes.
doi.org/10.1038/s415...
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes - Nature Immunology
Harty and colleagues report that physiological microbial exposures in mice can enhance memory T cell presence in the brain and influence neurological disease outcomes.
doi.org
June 13, 2025 at 4:50 PM
Excited to share my research at #IMMUNOLOGY2025™!
Come talk to me at my poster #1066 on May 6th (Tue) from 13:15-14:30 HST, to learn more about how radiation exposure regulates the host's CD4 T cell functional response to infection and autoimmunity. Hope to see you there! #AAI2025 #immunology
April 29, 2025 at 5:15 PM
Accurate enumeration of Ag-specific and virtual memory CD8 T cells are important to get a true sense of protective CD8 T cell response generated against infections and vaccination strategies.

Excited to tell you more in our recent publication in @jimmunol.bsky.social

doi.org/10.1093/jimm...
Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection
Abstract. Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for
doi.org
April 3, 2025 at 4:43 AM
Reposted by Shravan Kumar Kannan
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 24, 2025 at 4:17 PM
Reposted by Shravan Kumar Kannan
By @katherinejwu.com

"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,”

The NIH is in a struggle for its (and our) lives. This is existential to America:
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 27, 2025 at 5:29 PM
Reposted by Shravan Kumar Kannan
Not forgetting T cells at 🎓 Immunoschool 🎓 !

Rafi Ahmed defined T cell exhaustion, a hurdle his work on PD-1 blockade helped clear to establish immune checkpoint therapy for cancer. His T cell memory research shapes vaccine & antiviral strategies. REGISTER FREE: www.eventbrite.com/e/internatio...
February 27, 2025 at 10:32 PM
Reposted by Shravan Kumar Kannan
Congratulations to ⁦Shailesh Shahi, a junior faculty in my program for receiving NMSS research grant as it’s always special feeling when your mentees make progress in thi career and getting your first grant as PI is always special. Being persistent and hard work finally paid of👏👏 #proudmentor
February 2, 2025 at 4:47 PM
📣 Congrats to Dr. Cori Fain! 🎉
She is the first-ever University of lowa recipient of the Hanna H. Gray Fellowship from the HHMI. The eight-year, $1.5 million award will support Fain's research on how the body's past infections can alter the brain, possibly accelerating brain aging.
#HannaGrayFellows
📣 Thrilled to announce that I’ve been named an HHMI #HannaGrayFellows ! 🎉 
 
This fellowship supports early-career scientists like me as we push the boundaries of scientific discovery. I’m excited to further my research and be a part of this incredible community! @hhmi.bsky.social
Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!
January 9, 2025 at 12:21 AM
Reposted by Shravan Kumar Kannan
I am excited to finally share my website and blog that I have been working on developing over the holidays! This also serves as a central hub for content I put out on TikTok, YouTube, LinkedIn, and Instagram!

First blog post is up now!

hdpgetsherphd.wixsite.com/hdp-gets-her...
Home | Hdp Gets Her Phd
hdpgetsherphd.wixsite.com
January 6, 2025 at 3:49 AM
Reposted by Shravan Kumar Kannan
#ICYMI Dr. Gail Bishop from the @uiowa talks about her research on TRAF signaling and her work as Editor-in-Chief of The Journal of Immunology! 📚

Listen now: bit.ly/3ZGdo0a
Ep. 95: "Lymphocyte Signaling" Featuring Dr. Gail Bishop - The Immunology Podcast
Dr. Gail Bishop is a Professor of Microbiology and Immunology at the University of Iowa, where her lab studies the molecular mechanisms underlying lymphocyte activation and tolerance.  She talks about...
bit.ly
December 26, 2024 at 3:30 PM
Reposted by Shravan Kumar Kannan
KEAP1-mediated suppression of NRF2 required for optimal expansion of CD8+ T cells during chronic antigen exposure:

www.science.org/doi/10.1126/...
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
www.science.org
November 29, 2024 at 9:32 PM
Reposted by Shravan Kumar Kannan
Behind the graduate mental health crisis in science go.nature.com/3Z5GqHl
Behind the graduate mental health crisis in science - Nature Biotechnology
Survey results identify how scientific research and teaching contribute to the graduate student mental health crisis.
go.nature.com
November 14, 2024 at 3:13 PM
Reposted by Shravan Kumar Kannan
"Large language models surpass human experts in predicting neuroscience results" w @ken-lxl.bsky.social
and braingpt.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s41... 1/8
November 27, 2024 at 2:13 PM
Mitochondrial supplements to improve T cell fitness!

An Interesting research, connecting my MS research interest (Tunneling Nanotubes- TNTs) with my current PhD research interest (T cell fitness)
#Immunology #cellbiology #Tcells

www.cell.com/cell/fulltex...
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract exhausti...
www.cell.com
November 21, 2024 at 11:33 PM