Sally Church
@maverickny.bsky.social
Scientist, cancer geek, journalist, Londoner, always curious, adventurer, explorer, immigrant, lover of curry, fine wine & football
Reposted by Sally Church
RFK Jr & his loyal henchmen (the Great Barrington Declaration dudes Jay Bhattacharya & Martin Kulldorff; Martin Makary; Dr Oz; Vinay Prasad) have been successfully dismantling the US vaccination system & achieved the return of deadly vaccine preventable diseases. This is the world they worked for...
SCOOP: CDC officials on Monday linked for the first time the measles outbreak that began in Texas with another in Utah and Arizona, a finding that could end America’s status as a nation that has eliminated measles.
(Gift link)
www.nytimes.com/2025/11/17/h...
(Gift link)
www.nytimes.com/2025/11/17/h...
C.D.C. Links Measles Outbreaks in Multiple States for the First Time
www.nytimes.com
November 18, 2025 at 2:03 AM
RFK Jr & his loyal henchmen (the Great Barrington Declaration dudes Jay Bhattacharya & Martin Kulldorff; Martin Makary; Dr Oz; Vinay Prasad) have been successfully dismantling the US vaccination system & achieved the return of deadly vaccine preventable diseases. This is the world they worked for...
Reposted by Sally Church
The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more:
buff.ly/dzZnhJr
#AACR26
buff.ly/dzZnhJr
#AACR26
November 18, 2025 at 2:12 PM
The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more:
buff.ly/dzZnhJr
#AACR26
buff.ly/dzZnhJr
#AACR26
A metaphor for life….
Frog pulled Toad up onto the island. Toad looked in the basket. The sandwiches were wet. The pitcher of iced tea was empty.
November 4, 2025 at 1:43 PM
A metaphor for life….
Reposted by Sally Church
The 2026 Chemistry Faculty Jobs List has 170 tenure-track positions and 19 teaching positions: docs.google.com/spreadsheets... #facultychemjobs #chemjobs #chemsky 🧪⚗️
The 2026 Chemistry Faculty Jobs List
docs.google.com
September 23, 2025 at 1:48 PM
The 2026 Chemistry Faculty Jobs List has 170 tenure-track positions and 19 teaching positions: docs.google.com/spreadsheets... #facultychemjobs #chemjobs #chemsky 🧪⚗️
Reposted by Sally Church
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Reposted by Sally Church
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology.
science.org/doi/10.1126/sc…shorturl.at/976aj#mycompnayay
science.org/doi/10.1126/sc…shorturl.at/976aj#mycompnayay
https://science.org/doi/10.1126/sc…
August 22, 2025 at 4:29 AM
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology.
science.org/doi/10.1126/sc…shorturl.at/976aj#mycompnayay
science.org/doi/10.1126/sc…shorturl.at/976aj#mycompnayay
Reposted by Sally Church
What’s your last primary literature publication(s) in the face of future funding being destroyed?
I’ve got 2:
1) ADAM17 inhibition prevents pancreatic oncogenesis and tumor progression
2) TSHZ2 maintains the hybrid subtype of pancreatic cancer
We will be lucky to finish #2 without more funding
I’ve got 2:
1) ADAM17 inhibition prevents pancreatic oncogenesis and tumor progression
2) TSHZ2 maintains the hybrid subtype of pancreatic cancer
We will be lucky to finish #2 without more funding
August 21, 2025 at 9:50 AM
What’s your last primary literature publication(s) in the face of future funding being destroyed?
I’ve got 2:
1) ADAM17 inhibition prevents pancreatic oncogenesis and tumor progression
2) TSHZ2 maintains the hybrid subtype of pancreatic cancer
We will be lucky to finish #2 without more funding
I’ve got 2:
1) ADAM17 inhibition prevents pancreatic oncogenesis and tumor progression
2) TSHZ2 maintains the hybrid subtype of pancreatic cancer
We will be lucky to finish #2 without more funding
Reposted by Sally Church
Finally out! This is an amazing story on lipid trafficking and how to visualize membrane lipids inside of cells! Check it out. I am honored I could contribute a little to this story 😁
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 6:01 AM
Finally out! This is an amazing story on lipid trafficking and how to visualize membrane lipids inside of cells! Check it out. I am honored I could contribute a little to this story 😁
Reposted by Sally Church
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
August 18, 2025 at 4:14 AM
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
Reposted by Sally Church
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
August 10, 2025 at 7:50 PM
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
Reposted by Sally Church
Grateful to Sally Church for her incisive review of our recent @science.org manuscript, capturing its significance — from target space expansion to pharmacologic implications to the evolving therapeutic landscape. @maverickny.bsky.social
biotechstrategyblog.com/2025/07/how-...
biotechstrategyblog.com/2025/07/how-...
How Monte Rosa just rewrote the Degrader Playbook | Biotech Strategy Blog
biotechstrategyblog.com
July 11, 2025 at 12:39 PM
Grateful to Sally Church for her incisive review of our recent @science.org manuscript, capturing its significance — from target space expansion to pharmacologic implications to the evolving therapeutic landscape. @maverickny.bsky.social
biotechstrategyblog.com/2025/07/how-...
biotechstrategyblog.com/2025/07/how-...
Reposted by Sally Church
Exciting news from Finland: the world’s largest sand battery (1 MW/100 MWh) is now online!
The Pornainen project by Polar Night Energy is 10x bigger than the first commercial sand battery and sets a new benchmark for affordable, long-duration energy storage.
The Pornainen project by Polar Night Energy is 10x bigger than the first commercial sand battery and sets a new benchmark for affordable, long-duration energy storage.
June 29, 2025 at 2:06 PM
Exciting news from Finland: the world’s largest sand battery (1 MW/100 MWh) is now online!
The Pornainen project by Polar Night Energy is 10x bigger than the first commercial sand battery and sets a new benchmark for affordable, long-duration energy storage.
The Pornainen project by Polar Night Energy is 10x bigger than the first commercial sand battery and sets a new benchmark for affordable, long-duration energy storage.
Reposted by Sally Church
If you are a PhD or postdoc and want to present your work alongside e.g. Sarah O'Connor and @craigmcrews.bsky.social, you still have two weeks to apply for a Flash Talk at the 5th Virtual ChemBioTalks. Deadline is June 30th.
chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
#ChemBio #ChemSky
chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
#ChemBio #ChemSky
June 17, 2025 at 7:43 AM
If you are a PhD or postdoc and want to present your work alongside e.g. Sarah O'Connor and @craigmcrews.bsky.social, you still have two weeks to apply for a Flash Talk at the 5th Virtual ChemBioTalks. Deadline is June 30th.
chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
#ChemBio #ChemSky
chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
#ChemBio #ChemSky
Reposted by Sally Church
Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social
June 10, 2025 at 10:05 PM
Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social
Reposted by Sally Church
Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation
Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation
HPK1 is an attractive therapeutic target for tumor immunotherapy. Nevertheless, the formidable challenge selectivity over GLK and limited antitumor efficacy of HPK1 inhibitors and PROTACs impeded thei...
pubs.acs.org
June 11, 2025 at 11:01 AM
Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation
Reposted by Sally Church
Paracetamol (aka acetaminophen, Tylenol, Panadol, Calpol) has been one of the world’s most widely used painkillers, yet like its precise mechanism of action remained unclear...
June 11, 2025 at 11:10 AM
Paracetamol (aka acetaminophen, Tylenol, Panadol, Calpol) has been one of the world’s most widely used painkillers, yet like its precise mechanism of action remained unclear...
Reposted by Sally Church
The spread of Mpox in Sierra Leone is unlike anything we have ever seen - and we have been keeping an eye on this bug in the region for >15 years.
Given geographical spread, 50/50 men vs women, this is no "sexual network".
This could be the next one.
clt.npha.gov.sl/outbreak.aspx
Given geographical spread, 50/50 men vs women, this is no "sexual network".
This could be the next one.
clt.npha.gov.sl/outbreak.aspx
May 22, 2025 at 9:56 PM
The spread of Mpox in Sierra Leone is unlike anything we have ever seen - and we have been keeping an eye on this bug in the region for >15 years.
Given geographical spread, 50/50 men vs women, this is no "sexual network".
This could be the next one.
clt.npha.gov.sl/outbreak.aspx
Given geographical spread, 50/50 men vs women, this is no "sexual network".
This could be the next one.
clt.npha.gov.sl/outbreak.aspx
Had fun creating a cheesy cartoon on AI for a blog post on T cell engagers…
biotechstrategyblog.com/2025/05/t-ce...
biotechstrategyblog.com/2025/05/t-ce...
May 26, 2025 at 3:00 PM
Had fun creating a cheesy cartoon on AI for a blog post on T cell engagers…
biotechstrategyblog.com/2025/05/t-ce...
biotechstrategyblog.com/2025/05/t-ce...
Reposted by Sally Church
Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 25, 2025 at 11:46 PM
Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!
Reposted by Sally Church
We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international)
We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.
Download this massive database here for free: research.jhu.edu/rdt/funding-...
We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.
Download this massive database here for free: research.jhu.edu/rdt/funding-...
May 7, 2025 at 4:46 PM
We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international)
We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.
Download this massive database here for free: research.jhu.edu/rdt/funding-...
We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc.
Download this massive database here for free: research.jhu.edu/rdt/funding-...
Reposted by Sally Church
So, how many genetic diseases come down to good ol’ loss-of-function in the targeted protein?
Your estimate is probably too high:
Your estimate is probably too high:
Mutant Proteins Classified
www.science.org
May 7, 2025 at 7:08 PM
So, how many genetic diseases come down to good ol’ loss-of-function in the targeted protein?
Your estimate is probably too high:
Your estimate is probably too high:
Reposted by Sally Church
Important message. Also important to remember that federal funding for science isn’t “given” to university laboratories - it is awarded based on highly competitive process, profs spend months/years on proposals that are reviewed by experts, most are rejected.
www.young.senate.gov/newsroom/pre...
www.young.senate.gov/newsroom/pre...
Young, Pottinger Op-Ed: Funding for R&D Isn’t a Gift to Academia. It's Vital to U.S. Security. - Senator Young
The following column by Senator Todd Young (R-Ind.) and Matthew Pottinger, Former Deputy National Security Advisor of the United States, was published in The Washington Post on March 24, 2025. By Sena...
www.young.senate.gov
May 6, 2025 at 10:35 PM
Important message. Also important to remember that federal funding for science isn’t “given” to university laboratories - it is awarded based on highly competitive process, profs spend months/years on proposals that are reviewed by experts, most are rejected.
www.young.senate.gov/newsroom/pre...
www.young.senate.gov/newsroom/pre...
Reposted by Sally Church
There's a good explainer here: www.scientificamerican.com/article/chem...
The Pyrotechnic Chemistry of the Vatican’s Pope Smoke Signals Explained
Pyrotechnic chemistry drives the Vatican’s recipes for the black and white smoke used to announce papal election outcomes
www.scientificamerican.com
May 7, 2025 at 8:08 PM
There's a good explainer here: www.scientificamerican.com/article/chem...
Reposted by Sally Church
“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”
www.nytimes.com/2025/04/28/o...
www.nytimes.com/2025/04/28/o...
Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing
Underlying many investments are breakthroughs in medicine and technology from great universities.
www.nytimes.com
April 30, 2025 at 5:58 AM
“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”
www.nytimes.com/2025/04/28/o...
www.nytimes.com/2025/04/28/o...