Sean Flynn
@seanflynn.bsky.social
Enhancers and 3D genome structure | Lecturer @uniofexeter.bsky.social | sites.google.com/view/flynnlab/
Lots of exciting PhD projects available through @swbiodtp.bsky.social
If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged
Project:
www.swbio.ac.uk/files/2025/1...
If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged
Project:
www.swbio.ac.uk/files/2025/1...
November 6, 2025 at 3:34 PM
Lots of exciting PhD projects available through @swbiodtp.bsky.social
If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged
Project:
www.swbio.ac.uk/files/2025/1...
If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged
Project:
www.swbio.ac.uk/files/2025/1...
Exciting postdoc opportunity!
📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!
October 21, 2025 at 2:28 PM
Exciting postdoc opportunity!
Reposted by Sean Flynn
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 4:51 PM
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by Sean Flynn
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1
August 30, 2025 at 4:18 PM
Check it out, Chromatin Kids!
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Chromatin remodeller does stuff to Transcription Factors!
Functions where it is seldom seen!
Both decreases and increases chromatin accessibility!
How cool is that?
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...
gw4biomed.ac.uk
September 2, 2025 at 12:22 PM
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Reposted by Sean Flynn
Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...
Giant study finds a research field that’s mostly reproducible
Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.
www.nature.com
July 16, 2025 at 5:55 PM
Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...
Reposted by Sean Flynn
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers - Genome Biology
Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...
doi.org
June 4, 2025 at 9:00 PM
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
Reposted by Sean Flynn
Happy to be part of this exciting work. A must-read for enhancer aficionados: A massive effort has gone into generating genome-wide STARRseq in hPSCs and conducting functional validation assays. Congratulations to all authors, Stefan and Ufuk, for leading this project 🎉.
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social:
www.biorxiv.org/content/10.1...
🧵 below
www.biorxiv.org/content/10.1...
🧵 below
Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...
www.biorxiv.org
June 3, 2025 at 6:06 AM
Happy to be part of this exciting work. A must-read for enhancer aficionados: A massive effort has gone into generating genome-wide STARRseq in hPSCs and conducting functional validation assays. Congratulations to all authors, Stefan and Ufuk, for leading this project 🎉.
Reposted by Sean Flynn
Please get in touch if you want to apply for this to work with me on chromatin remodellers, enhancers and lineage commitment in mammalian stem cells at @lsiexeter.bsky.social
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 11:08 AM
Please get in touch if you want to apply for this to work with me on chromatin remodellers, enhancers and lineage commitment in mammalian stem cells at @lsiexeter.bsky.social
Reposted by Sean Flynn
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
April 25, 2025 at 7:29 AM
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
Reposted by Sean Flynn
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
April 17, 2025 at 3:45 PM
Job alert 🚨 We are hiring a research assistant!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.
Please spread the word!
Reposted by Sean Flynn
We have a postdoc position in my group in collaboration with EMBL Rome; join us to make important discoveries in this exciting project.
Please apply or share.
hrwebapp.qub.ac.uk/tlive_webrec...
Please apply or share.
hrwebapp.qub.ac.uk/tlive_webrec...
March 31, 2025 at 10:32 AM
We have a postdoc position in my group in collaboration with EMBL Rome; join us to make important discoveries in this exciting project.
Please apply or share.
hrwebapp.qub.ac.uk/tlive_webrec...
Please apply or share.
hrwebapp.qub.ac.uk/tlive_webrec...
Reposted by Sean Flynn
We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!
Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!
allirelandchromatinconsortium.ie/annual-meeti...
Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!
allirelandchromatinconsortium.ie/annual-meeti...
March 24, 2025 at 12:03 PM
We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today!
Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!
allirelandchromatinconsortium.ie/annual-meeti...
Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters!
allirelandchromatinconsortium.ie/annual-meeti...
We have a funded PhD position available in Exeter @exeter.ac.uk
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Award details | Funding and scholarships for students | University of Exeter
www.exeter.ac.uk
March 3, 2025 at 10:57 AM
We have a funded PhD position available in Exeter @exeter.ac.uk
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Reposted by Sean Flynn
jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Powered by MHR
jobs.exeter.ac.uk
December 16, 2024 at 8:44 PM
jobs.exeter.ac.uk/hrpr_webrecr...
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!
Happy to share our preprint on our favourite polyploid hybrid, Arabidopsis suecica. We examine the evolutionary cycle of polyploidy in this young allotetraploid, focusing on three key parts of the cycle: origin, meiotic adaptation and rediploidization
Diploid origins, adaptation to polyploidy, and the beginning of rediploidization in allotetraploid Arabidopsis suecica https://www.biorxiv.org/content/10.1101/2024.12.06.627142v1
December 11, 2024 at 5:48 PM
If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter.
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
November 22, 2024 at 4:30 PM
If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter.
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
Reposted by Sean Flynn
Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
November 19, 2024 at 3:58 PM
Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
Reposted by Sean Flynn
Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
LSI PhD programme | Living Systems Institute | University of Exeter
www.exeter.ac.uk
November 7, 2024 at 7:17 AM
Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
Welcome @kherka.bsky.social, who is working on chromatin and G4s
November 14, 2024 at 8:43 PM
Welcome @kherka.bsky.social, who is working on chromatin and G4s