Krzysztof Herka
@kherka.bsky.social
PhD student, Balasubramanian lab, Cancer Research UK - Cambridge Institute (@cruk-ci.bsky.social)
Pinned
Krzysztof Herka
@kherka.bsky.social
· Jun 4
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers - Genome Biology
Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...
doi.org
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models
gw4biomed.ac.uk/architects-o...
gw4biomed.ac.uk/risk-vs-prot...
gw4biomed.ac.uk/rna-dependen...
gw4biomed.ac.uk/investigatin...
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders - GW4 BioMed MRC DTP
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Sum...
gw4biomed.ac.uk
September 2, 2025 at 2:08 PM
Lots of exciting chromatin biology - and great recaps!
Eva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed
August 27, 2025 at 7:29 PM
Lots of exciting chromatin biology - and great recaps!
Reposted by Krzysztof Herka
Beyond carrying out vital research, our staff are involved in lots of science outreach activities every year.
Recently, we hosted pupils for our annual Careers Lab. This programme is designed to inspire the next generation of STEM scientists & supporters.
More: www.cruk.cam.ac.uk/students/car...
Recently, we hosted pupils for our annual Careers Lab. This programme is designed to inspire the next generation of STEM scientists & supporters.
More: www.cruk.cam.ac.uk/students/car...
July 21, 2025 at 12:54 PM
Beyond carrying out vital research, our staff are involved in lots of science outreach activities every year.
Recently, we hosted pupils for our annual Careers Lab. This programme is designed to inspire the next generation of STEM scientists & supporters.
More: www.cruk.cam.ac.uk/students/car...
Recently, we hosted pupils for our annual Careers Lab. This programme is designed to inspire the next generation of STEM scientists & supporters.
More: www.cruk.cam.ac.uk/students/car...
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers - Genome Biology
Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...
doi.org
June 4, 2025 at 9:00 PM
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
Reposted by Krzysztof Herka
We heard about "Alternative DNA structures in enhancer-promoter communication" from @seanflynn.bsky.social from @uniofexeter.bsky.social #Epigenetics2025
@uniofexeternews.bsky.social
@uniofexeternews.bsky.social
April 23, 2025 at 2:00 PM
We heard about "Alternative DNA structures in enhancer-promoter communication" from @seanflynn.bsky.social from @uniofexeter.bsky.social #Epigenetics2025
@uniofexeternews.bsky.social
@uniofexeternews.bsky.social
Reposted by Krzysztof Herka
🚨 We’re Hiring!🚨
Passionate about cancer research? Join Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
We have two exciting opportunities:
Research Associate: jobs.cam.ac.uk/job/50675/
Senior Scientific Associate: jobs.cam.ac.uk/job/50689/
Passionate about cancer research? Join Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
We have two exciting opportunities:
Research Associate: jobs.cam.ac.uk/job/50675/
Senior Scientific Associate: jobs.cam.ac.uk/job/50689/
March 19, 2025 at 10:18 AM
🚨 We’re Hiring!🚨
Passionate about cancer research? Join Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
We have two exciting opportunities:
Research Associate: jobs.cam.ac.uk/job/50675/
Senior Scientific Associate: jobs.cam.ac.uk/job/50689/
Passionate about cancer research? Join Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
We have two exciting opportunities:
Research Associate: jobs.cam.ac.uk/job/50675/
Senior Scientific Associate: jobs.cam.ac.uk/job/50689/
Reposted by Krzysztof Herka
🚨 Fully funded #PhD opportunity! 🚨
Passionate about cancer research? Join Dr Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
📍 Cambridge, UK
💰 Fully funded
📅 Apply by 24 March 2025
www.cruk.cam.ac.uk/vacancies/ph...
Passionate about cancer research? Join Dr Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
📍 Cambridge, UK
💰 Fully funded
📅 Apply by 24 March 2025
www.cruk.cam.ac.uk/vacancies/ph...
PhD Studentship: Investigating the causes and consequences of R-loop dysregulation in cancer - Cancer Research UK Cambridge Institute
Supervisor: Dr Magdalena Crossley Department/location: Cancer Research UK Cambridge Institute (CRUK CI) Course start date: 1st October 2025 Overview Dr Magdalena Crossley wishes to recruit a PhD stude...
www.cruk.cam.ac.uk
March 5, 2025 at 10:54 AM
🚨 Fully funded #PhD opportunity! 🚨
Passionate about cancer research? Join Dr Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
📍 Cambridge, UK
💰 Fully funded
📅 Apply by 24 March 2025
www.cruk.cam.ac.uk/vacancies/ph...
Passionate about cancer research? Join Dr Madzia Crossley's team to investigate how R-loop dysregulation contributes to cancer.
📍 Cambridge, UK
💰 Fully funded
📅 Apply by 24 March 2025
www.cruk.cam.ac.uk/vacancies/ph...
A great opportunity to work on #epigenetics, #genetics and gene regulation in #neuroscience with an inspirational young PI - please share and apply!
We have a funded PhD position available in Exeter @exeter.ac.uk
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Gene Regulation in Brain Development and Disease 🧬
Please share / repost
www.exeter.ac.uk/study/fundin...
Award details | Funding and scholarships for students | University of Exeter
www.exeter.ac.uk
March 3, 2025 at 12:17 PM
A great opportunity to work on #epigenetics, #genetics and gene regulation in #neuroscience with an inspirational young PI - please share and apply!
Reposted by Krzysztof Herka
Congratulations to @isabelesain.bsky.social, who is awarded the 2024 CRUK Cambridge Institute PhD Thesis Prize.
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
December 3, 2024 at 1:20 PM
Congratulations to @isabelesain.bsky.social, who is awarded the 2024 CRUK Cambridge Institute PhD Thesis Prize.
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
A great #PhD opportunity for anyone interested in #epigenetics in #neurons and the broader context of #neuroscience - having worked with @seanflynn.bsky.social and Jack, they are brilliant choices for mentors!
If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter.
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
Elucidating the role of DNA modifications in neurons
Funded by #SWBio DTP
Deadline: Dec 4
To apply: www.swbio.ac.uk/programme/ho...
November 22, 2024 at 6:44 PM
A great #PhD opportunity for anyone interested in #epigenetics in #neurons and the broader context of #neuroscience - having worked with @seanflynn.bsky.social and Jack, they are brilliant choices for mentors!