Krzysztof Herka
@kherka.bsky.social
PhD student, Balasubramanian lab, Cancer Research UK - Cambridge Institute (@cruk-ci.bsky.social)
What happened? In the alpha HS-40 enhancer, such a mutation (seven G-to-T mutations) was sufficient to reduce globin gene expression to levels observed when the whole enhancer region (of around 350 bases) is deleted. Enhancer-promoter contacts and local #chromatin accessibility is also reduced. 3/9
June 4, 2025 at 9:00 PM
What happened? In the alpha HS-40 enhancer, such a mutation (seven G-to-T mutations) was sufficient to reduce globin gene expression to levels observed when the whole enhancer region (of around 350 bases) is deleted. Enhancer-promoter contacts and local #chromatin accessibility is also reduced. 3/9