Michael Scherer
@scherermich.bsky.social
Group leader in Computational Biology working on (single-cell) epigenomics and cancer @dkfz.bsky.social
@scherermichael@genomic.social
https://orcid.org/0000-0001-7990-6179
@scherermichael@genomic.social
https://orcid.org/0000-0001-7990-6179
If you are thinking where to do your Postdoc, I can only give my highest recommendations to join Lars and his team!
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
November 20, 2025 at 9:58 AM
If you are thinking where to do your Postdoc, I can only give my highest recommendations to join Lars and his team!
Reposted by Michael Scherer
Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....
genzplyr is dplyr, but bussin fr fr no cap.
genzplyr is dplyr, but bussin fr fr no cap.
GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap
dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.
github.com
November 6, 2025 at 11:25 PM
Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....
genzplyr is dplyr, but bussin fr fr no cap.
genzplyr is dplyr, but bussin fr fr no cap.
Reposted by Michael Scherer
🚀 Thinking about your next big career step in science?
The Int'l PhD Program at DKFZ could be a perfect fit for you.
🌍 Work in an international environment, with 500+ doctoral researchers
🔬 Do cutting-edge cancer research
Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3
The Int'l PhD Program at DKFZ could be a perfect fit for you.
🌍 Work in an international environment, with 500+ doctoral researchers
🔬 Do cutting-edge cancer research
Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3
November 5, 2025 at 9:57 AM
🚀 Thinking about your next big career step in science?
The Int'l PhD Program at DKFZ could be a perfect fit for you.
🌍 Work in an international environment, with 500+ doctoral researchers
🔬 Do cutting-edge cancer research
Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3
The Int'l PhD Program at DKFZ could be a perfect fit for you.
🌍 Work in an international environment, with 500+ doctoral researchers
🔬 Do cutting-edge cancer research
Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3
Reposted by Michael Scherer
This was a lot of fun! Thanks Daylon and @arunsharmaphd.bsky.social for being great hosts!
We have a new episode out!
Dr. Lars Velten from the Centre for Genomic Regulation talks about his research on #LineageTracing and #hematopoiesis: https://bit.ly/4gsvo5X
Dr. Lars Velten from the Centre for Genomic Regulation talks about his research on #LineageTracing and #hematopoiesis: https://bit.ly/4gsvo5X
September 18, 2025 at 10:09 AM
This was a lot of fun! Thanks Daylon and @arunsharmaphd.bsky.social for being great hosts!
DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas.
doi.org/10.1007/s004...
doi.org/10.1007/s004...
DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma - Acta Neuropathologica
IDH-mutant gliomas represent a subtype of diffuse gliomas that primarily affect patients in early to mid-adolescence. These tumors are classified into three distinct CNS WHO grades of malignancy. Accu...
doi.org
September 8, 2025 at 7:07 AM
DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas.
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Reposted by Michael Scherer
#IRBBarcelona & @crg.eu scientists identify DNA “barcodes” that mark blood cell #aging—accelerating after 50. Published in @nature.com, the work could pave the way for preventive, personalized #antiaging therapies.
https://youtu.be/ST5YmqqMcuQ
@alejofraticelli.bsky.social
#AgingResearch
🧪
https://youtu.be/ST5YmqqMcuQ
@alejofraticelli.bsky.social
#AgingResearch
🧪
Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.
youtu.be
August 12, 2025 at 9:03 AM
#IRBBarcelona & @crg.eu scientists identify DNA “barcodes” that mark blood cell #aging—accelerating after 50. Published in @nature.com, the work could pave the way for preventive, personalized #antiaging therapies.
https://youtu.be/ST5YmqqMcuQ
@alejofraticelli.bsky.social
#AgingResearch
🧪
https://youtu.be/ST5YmqqMcuQ
@alejofraticelli.bsky.social
#AgingResearch
🧪
Reposted by Michael Scherer
Ein Team aus Forschenden vom BIH, @mdc-berlin.bsky.social, DKFZ, HI-STEM und @qmul.bsky.social hat eine Technologie zur Entschlüsselung der Immunzell-Kommunikation entwickelt. Damit lässt sich unter anderem ablesen, warum Immuntherapien bei manchen Menschen wirken bei anderen nicht.
t1p.de/w3v16
t1p.de/w3v16
Wie Immunzellen kommunizieren, um Krankheiten und Krebs zu bekämpfen
Ein interdisziplinäres Team aus Wissenschaftlerinnen und Wissenschaftlern vom Berlin Institute of Health in der Charité (BIH), vom Max Delbrück Center, dem Deutschen Krebsforschungszentrum (DKFZ), dem...
t1p.de
August 7, 2025 at 12:43 PM
Ein Team aus Forschenden vom BIH, @mdc-berlin.bsky.social, DKFZ, HI-STEM und @qmul.bsky.social hat eine Technologie zur Entschlüsselung der Immunzell-Kommunikation entwickelt. Damit lässt sich unter anderem ablesen, warum Immuntherapien bei manchen Menschen wirken bei anderen nicht.
t1p.de/w3v16
t1p.de/w3v16
Reposted by Michael Scherer
Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
August 7, 2025 at 11:24 AM
Excited to share our latest paper @natmethods.nature.com
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4).
www.nature.com/articles/s41...
Reposted by Michael Scherer
Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response https://www.biorxiv.org/content/10.1101/2025.07.30.667694v1
August 2, 2025 at 7:48 AM
Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response https://www.biorxiv.org/content/10.1101/2025.07.30.667694v1
Do you want to improve our understanding of therapy resistance induced by epigenetic heterogeneity? Do you have a PhD in Molecular Biology or related fields? Join us as a (fully-funded) Postdoc in the Division of Cancer Epigenomics at DKFZ. More information here: www.dkfz.de/en/cancer-ep...
Cancer Epigenomics - German Cancer Research Center
www.dkfz.de
July 18, 2025 at 6:54 AM
Do you want to improve our understanding of therapy resistance induced by epigenetic heterogeneity? Do you have a PhD in Molecular Biology or related fields? Join us as a (fully-funded) Postdoc in the Division of Cancer Epigenomics at DKFZ. More information here: www.dkfz.de/en/cancer-ep...
Out in Leukemia (@natureportfolio.nature.com). Hypomethylating agents (HMAs) such as decitabine are used in clinical practice for the treatment of Acute Myeloid Leukemia and expected to re-activate tumor suppressor genes de-activated by aberrant DNA methylation.
July 15, 2025 at 11:22 AM
Out in Leukemia (@natureportfolio.nature.com). Hypomethylating agents (HMAs) such as decitabine are used in clinical practice for the treatment of Acute Myeloid Leukemia and expected to re-activate tumor suppressor genes de-activated by aberrant DNA methylation.
Reposted by Michael Scherer
The next #ScienceatDKFZ event will take place on Monday, 23 June 2025, at 4 pm. In addition to the keynote lecture by Chong Sun, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...
➡️ dkfz.de/en/news/even...
June 20, 2025 at 7:30 AM
The next #ScienceatDKFZ event will take place on Monday, 23 June 2025, at 4 pm. In addition to the keynote lecture by Chong Sun, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...
➡️ dkfz.de/en/news/even...
Reposted by Michael Scherer
Stunning @nature.com paper from the labs of our great friends @larsplus.bsky.social and @alejofraticelli.bsky.social on modelling somatic epimutations for transgene-free single-cell clonal tracing in blood ageing! Enjoy the read: doi.org/10.1038/s415... 🧪
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
doi.org
June 13, 2025 at 6:41 AM
Stunning @nature.com paper from the labs of our great friends @larsplus.bsky.social and @alejofraticelli.bsky.social on modelling somatic epimutations for transgene-free single-cell clonal tracing in blood ageing! Enjoy the read: doi.org/10.1038/s415... 🧪
Reposted by Michael Scherer
1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶
Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.
www.biorxiv.org/content/10.1...
With @benlehner.bsky.social
[1/7]
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶
Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.
www.biorxiv.org/content/10.1...
With @benlehner.bsky.social
[1/7]
The genetic architecture of an allosteric hormone receptor
Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...
www.biorxiv.org
June 2, 2025 at 1:36 PM
1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶
Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.
www.biorxiv.org/content/10.1...
With @benlehner.bsky.social
[1/7]
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶
Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.
www.biorxiv.org/content/10.1...
With @benlehner.bsky.social
[1/7]
Reposted by Michael Scherer
Thanks to phenomenal work by @crg.eu and @irbbarcelona.org press offices, we got to communicate our findings on 🧬 methylation barcodes and 🩸 blood ageing to a wide audience. A cool experience!
🧵 with highlights in 5 languages and funny moments 😬😅
cadenaser.com/nacional/202... (1/n)
🧵 with highlights in 5 languages and funny moments 😬😅
cadenaser.com/nacional/202... (1/n)
"A partir de los 50 casi todas las células madre se llaman Rodríguez" (Y eso es malo)
Un estudio liderado por dos centros de investigación de Barcelona ha descubierto que, a partir de esa edad, cada vez tenemos menos células madre sanguíneas y las que hay se replican cada vez con más e...
cadenaser.com
May 31, 2025 at 12:44 PM
Thanks to phenomenal work by @crg.eu and @irbbarcelona.org press offices, we got to communicate our findings on 🧬 methylation barcodes and 🩸 blood ageing to a wide audience. A cool experience!
🧵 with highlights in 5 languages and funny moments 😬😅
cadenaser.com/nacional/202... (1/n)
🧵 with highlights in 5 languages and funny moments 😬😅
cadenaser.com/nacional/202... (1/n)
Reposted by Michael Scherer
🇫🇷: @scherermich.bsky.social was brave enough to speak to @lemonde.fr in French 💪! Excellent article that definitely sticks out with the accompanying visual.
www.lemonde.fr/sciences/art... (6/n)
www.lemonde.fr/sciences/art... (6/n)
Dès l’âge de 50 ans, les cellules de notre sang s’appauvrissent
Une équipe espagnole a retracé l’évolution des lignées de cellules du sang chez 13 personnes de 35 à 70 ans. A partir de la cinquantaine, le nombre de cellules souches capables d’engendrer des cellule...
www.lemonde.fr
May 31, 2025 at 12:44 PM
🇫🇷: @scherermich.bsky.social was brave enough to speak to @lemonde.fr in French 💪! Excellent article that definitely sticks out with the accompanying visual.
www.lemonde.fr/sciences/art... (6/n)
www.lemonde.fr/sciences/art... (6/n)
Reposted by Michael Scherer
📢Die @dfg.de unterstützt in den kommenden vier Jahren den neuen Sonderforschungsbereich „Zelluläre Plastizität in malignen myeloischen Erkrankungen – Vom Mechanismus zur Therapie“ der Medizinischen Fakultät Heidelberg mit rund 15,8 Mio. Euro.
➡️ t1p.de/rpslw
➡️ t1p.de/rpslw
15,8 Millionen Euro für neuen Sonderforschungsbereich zu Blutkrebs
Die Deutsche Forschungsgemeinschaft (DFG) unterstützt in den kommenden vier Jahren den neuen Sonderforschungsbereich (SFB) 1709 „Zelluläre Plastizität in malignen myeloischen Erkrankungen – Vom Mechan...
t1p.de
May 30, 2025 at 8:18 AM
📢Die @dfg.de unterstützt in den kommenden vier Jahren den neuen Sonderforschungsbereich „Zelluläre Plastizität in malignen myeloischen Erkrankungen – Vom Mechanismus zur Therapie“ der Medizinischen Fakultät Heidelberg mit rund 15,8 Mio. Euro.
➡️ t1p.de/rpslw
➡️ t1p.de/rpslw
Reposted by Michael Scherer
The fantastic lineup for our latest webinar series, Unlocking the Epigenome: Precision Tools for Complex Diseases, includes: @chiaraherzog.bsky.social, @a-radzisheuskaya.bsky.social, @sankarinagarajan.bsky.social, @sebpreissl.bsky.social, @scherermich.bsky.social, and more! Check them out below!
How can cutting-edge tech help decode the complex #epigenome to reveal disease mechanisms, biomarkers & new therapies? Join us for the Unlocking the Epigenome: Precision Tools for Complex Diseases webinar series to find out. #epigenetics
Register now: hubs.la/Q03pFXJk0
Register now: hubs.la/Q03pFXJk0
May 29, 2025 at 12:01 PM
The fantastic lineup for our latest webinar series, Unlocking the Epigenome: Precision Tools for Complex Diseases, includes: @chiaraherzog.bsky.social, @a-radzisheuskaya.bsky.social, @sankarinagarajan.bsky.social, @sebpreissl.bsky.social, @scherermich.bsky.social, and more! Check them out below!
Reposted by Michael Scherer
Reposted by Michael Scherer
Tracing human clones and lineages with DNA methylation. Congratulations for this fascinating breakthrough!
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 26, 2025 at 6:38 PM
Tracing human clones and lineages with DNA methylation. Congratulations for this fascinating breakthrough!
Reposted by Michael Scherer
Reposted by Michael Scherer
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
www.nature.com
May 25, 2025 at 8:11 PM
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michael Scherer
Scientists make breakthroughs on blood ageing and limb regrowth
https://www.ft.com/content/a1f83886-fb29-4f5f-9577-bec61dfd31d2
https://www.ft.com/content/a1f83886-fb29-4f5f-9577-bec61dfd31d2
Scientists make breakthroughs on blood ageing and limb regrowth
Two new studies could help develop better therapies for rejuvenation and regeneration
www.ft.com
May 21, 2025 at 3:12 PM
Scientists make breakthroughs on blood ageing and limb regrowth
https://www.ft.com/content/a1f83886-fb29-4f5f-9577-bec61dfd31d2
https://www.ft.com/content/a1f83886-fb29-4f5f-9577-bec61dfd31d2
Reposted by Michael Scherer
#PCBCommunity |🩸Un equip de l’ @irbbarcelona.org i el @crg.eu identifica “codis de barres” en el #ADN que revelen com envelleix la #sang.
🔬 La recerca publicada en @nature.com obre la porta a noves estratègies per la detecció de la #leucèmia mieloide i les malalties #cardiovasculars i immunitàries.
🔬 La recerca publicada en @nature.com obre la porta a noves estratègies per la detecció de la #leucèmia mieloide i les malalties #cardiovasculars i immunitàries.
Investigadors de l'IRB Barcelona i del CRG identifiquen "codis de barres" escrits en el nostre ADN que revelen com envelleix la sang - Parc Científic de Barcelona
Identifiquen patrons de metilació naturals que desvelen canvis en la sang detectables a partir dels 50 anys i universals a partir dels 60.
www.pcb.ub.edu
May 22, 2025 at 10:21 AM
#PCBCommunity |🩸Un equip de l’ @irbbarcelona.org i el @crg.eu identifica “codis de barres” en el #ADN que revelen com envelleix la #sang.
🔬 La recerca publicada en @nature.com obre la porta a noves estratègies per la detecció de la #leucèmia mieloide i les malalties #cardiovasculars i immunitàries.
🔬 La recerca publicada en @nature.com obre la porta a noves estratègies per la detecció de la #leucèmia mieloide i les malalties #cardiovasculars i immunitàries.