Amir Toor
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Amir Toor
@aat2357.bsky.social
180 followers 360 following 87 posts
Stem cell transplant physician; apply mathematics to immunology; Professor UTSW
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www.nature.com/articles/s41...
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant - Nature
Nature - Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
www.nature.com
November 15, 2025 at 1:31 PM
www.nature.com/articles/s41...
Physiology and immunology of pig-to-human decedent kidney xenotransplant - Nature
Nature - Physiology and immunology of pig-to-human decedent kidney xenotransplant
www.nature.com
November 15, 2025 at 1:29 PM
www.medrxiv.org/content/10.1...
T cell tolerant fraction as a predictor of graft-vs-host disease following allogeneic hematopoietic cell transplantation
Background Donor T cell reconstitution following allogeneic hematopoietic cell transplantation (HCT) is crucial for protective immunity against infections and cancer relapse. However, its use remains ...
www.medrxiv.org
November 13, 2025 at 2:50 AM
www.science.org/doi/10.1126/...
B cells targeting parasites capture spatially linked antigens to secure T cell help
Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.
www.science.org
November 8, 2025 at 3:38 AM
www.science.org/doi/10.1126/...
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.
www.science.org
November 4, 2025 at 12:51 PM
Tumor Lysis Syndrome | New England Journal of Medicine www.nejm.org/doi/full/10....
Tumor Lysis Syndrome | NEJM
Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. This review explores risk factors and causes of the syndrome, as well as strategies for t...
www.nejm.org
November 1, 2025 at 11:29 AM
The IL-33 and IL-4Rα blocking antibodies itepekimab and dupilumab modulate both distinct and common inflammatory mediators in asthma | Science Translational Medicine www.science.org/doi/10.1126/...
www.science.org
November 1, 2025 at 10:28 AM
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine | Science Immunology www.science.org/doi/10.1126/...
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.
www.science.org
November 1, 2025 at 10:19 AM
www.nature.com/articles/d41...
Tumours might be sensitized to immune therapy by COVID mRNA vaccines
COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.
www.nature.com
October 23, 2025 at 3:53 AM
www.nature.com/articles/d41...
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 23, 2025 at 3:51 AM
www.science.org/doi/10.1126/...
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
www.science.org
October 10, 2025 at 11:43 PM
www.nobelprize.org/prizes/physi...
Nobel Prize in Physics 2025
The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electri...
www.nobelprize.org
October 7, 2025 at 11:20 AM
www.science.org/content/arti...
New radioactive isotope therapies promise more targeted attacks on cancer
Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies
www.science.org
October 7, 2025 at 12:40 AM
www.science.org/doi/10.1126/...
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
October 7, 2025 at 12:38 AM
www.science.org/doi/10.1126/...
Adenosine 2A receptor–dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming
Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.
www.science.org
September 28, 2025 at 10:43 PM
www.science.org/doi/10.1126/...
Design of a potent interleukin-21 mimic for cancer immunotherapy
A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
www.science.org
September 28, 2025 at 9:52 PM
Reposted by Amir Toor
bloodjournals.hematology.org
T-cell lymphopenia characterizes immunodeficiency in a broad spectrum of TBDs. buff.ly/6B7IlyR #hemesky
September 8, 2025 at 4:04 PM
www.bbc.com/news/article...
Newcastle University hopes to improve sepsis treatment nationwide
Sepsis is treated by antibiotics but using the medication too much can lead to deadly superbugs.
www.bbc.com
September 22, 2025 at 8:34 AM
www.science.org/doi/10.1126/...
Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
mTORC1 activation by components of a cytokine cocktail enhances NK cell cytotoxicity toward cancer cells.
www.science.org
September 17, 2025 at 1:39 AM
www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
www.science.org
September 17, 2025 at 1:35 AM
www.science.org/doi/10.1126/...
Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.
www.science.org
September 14, 2025 at 5:45 PM
www.science.org/doi/10.1126/...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 10, 2025 at 4:07 PM
www.nature.com/articles/d41...
Depriving brain tumours of an amino acid could enhance chemotherapy
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.
www.nature.com
September 7, 2025 at 8:06 PM
www.nature.com/articles/d41...
Newfound immune cell in mice hints at why inflammation spikes with old age
Pathogen-consuming cells found in fat tissue also play a part in lipid balance.
www.nature.com
September 7, 2025 at 8:02 PM
Reposted by Amir Toor
science.org
New research offers a glimpse of how RNA might have helped form the first simple proteins—an event that could have set the stage for evolution. https://scim.ag/466Rkz0
Here’s how the first proteins might have assembled, sparking life
RNA could have helped amino acids join up without preexisting protein machinery, lab study suggests
scim.ag
September 7, 2025 at 7:13 PM