Sascha Kuhn
@sascha-kuhn.bsky.social
How do cells see, smell, touch, and talk? Postdoc in the Mignot lab @LCB Marseille. Images -> Numbers (with units!). Also into guitars and amps.
Reposted by Sascha Kuhn
Not everybody knows that B.B. King wrote The Thrill Is Gone during the 2nd round of revisions
October 26, 2025 at 3:12 PM
Not everybody knows that B.B. King wrote The Thrill Is Gone during the 2nd round of revisions
Reposted by Sascha Kuhn
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
Tissue folding is a fundamental process occurring in animal organ development. Here, we study the progression of fold shape and the underlying mechanics in the development of the Drosophila wing disc....
doi.org
October 11, 2025 at 3:09 AM
How are tissue folds stabilized during animal organ development? Our latest preprint helps to answer this question, using the fruit fly wing disc as a model doi.org/10.1101/2025.... @poldresden.bsky.social @mpipks.bsky.social @dfg.de @janafuhrmann.bsky.social @vicioms.bsky.social @mbisg.bsky.social
Reposted by Sascha Kuhn
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 9:37 AM
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
Reposted by Sascha Kuhn
In 2019, Anna Jost & @jencwaters.bsky.social reviewed best practices for validating quantitative #microscopy methods & discuss strategies to avoid unconscious bias in imaging experiments rupress.org/jcb/article/...
📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...
📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...
September 11, 2025 at 2:06 PM
In 2019, Anna Jost & @jencwaters.bsky.social reviewed best practices for validating quantitative #microscopy methods & discuss strategies to avoid unconscious bias in imaging experiments rupress.org/jcb/article/...
📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...
📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...
Reposted by Sascha Kuhn
it was already fun to look around the documentation for cmap (cmap-docs.readthedocs.io)
but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂
as a mild deutan myself, I appreciate it! 🙏
but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂
as a mild deutan myself, I appreciate it! 🙏
July 5, 2025 at 8:28 PM
it was already fun to look around the documentation for cmap (cmap-docs.readthedocs.io)
but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂
as a mild deutan myself, I appreciate it! 🙏
but @grosoane.bsky.social just added a very cool feature to toggle between color vision deficiencies. Watch your perceptually uniform color maps gain some kinks 😂
as a mild deutan myself, I appreciate it! 🙏
If you are into imaging and quantitative biology, you should have a field day reading this. Also, of course, everyone who's into lipids ;) Huge congrats to the team!
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 7:01 AM
If you are into imaging and quantitative biology, you should have a field day reading this. Also, of course, everyone who's into lipids ;) Huge congrats to the team!
Reposted by Sascha Kuhn
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
August 20, 2025 at 9:01 PM
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
Reposted by Sascha Kuhn
Our review on contact-dependent #predation is now out ! We define predation processes and describe how predators kill and eat their prey 😈 Repost appreciated ❤️
#MicroSky Summer read!
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator &
prey 🧛
How do they do it?
Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social
www.sciencedirect.com/science/arti...
Strategies and mechanisms of contact-dependent predation in bacteria
Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…
www.sciencedirect.com
July 25, 2025 at 8:51 PM
Our review on contact-dependent #predation is now out ! We define predation processes and describe how predators kill and eat their prey 😈 Repost appreciated ❤️
Reposted by Sascha Kuhn
This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social
@joachimgoedhart.bsky.social
June 25, 2025 at 1:27 PM
This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social
@joachimgoedhart.bsky.social
Reposted by Sascha Kuhn
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
A checklist for designing and improving the visualization of scientific data
Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...
rdcu.be
June 18, 2025 at 8:33 AM
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
Reposted by Sascha Kuhn
Yep, we sure do! A fine thought technology from Katherine Andrea Rivera-Gomez and Mara Schvarzstein:
wbg.wormbook.org/2017/07/18/i...
wbg.wormbook.org/2017/07/18/i...
Immobilizing nematodes for live imaging using an agarose pad generated with a Vinyl Record
[insert_php]strip_tagsKatherine Andrea Rivera-Gomez and Mara Schvarzstein[/insert_php]
wbg.wormbook.org
June 1, 2025 at 12:43 PM
Yep, we sure do! A fine thought technology from Katherine Andrea Rivera-Gomez and Mara Schvarzstein:
wbg.wormbook.org/2017/07/18/i...
wbg.wormbook.org/2017/07/18/i...
Reposted by Sascha Kuhn
#KeinVergessen
Weil er öffentlich für Menschrechte von Geflüchteten einstand, wurde Walter Lübcke heute vor 6 Jahren von einem Neonazi ermordet. Der Mörder des CDU-Regierungspräsidenten von Kassel war u.a. bei #AfD aktiv und fasste den Tatplan nach AfD- und Neonazi-Mobilisierungen in #Chemnitz 2018.
Weil er öffentlich für Menschrechte von Geflüchteten einstand, wurde Walter Lübcke heute vor 6 Jahren von einem Neonazi ermordet. Der Mörder des CDU-Regierungspräsidenten von Kassel war u.a. bei #AfD aktiv und fasste den Tatplan nach AfD- und Neonazi-Mobilisierungen in #Chemnitz 2018.
June 1, 2025 at 11:14 AM
#KeinVergessen
Weil er öffentlich für Menschrechte von Geflüchteten einstand, wurde Walter Lübcke heute vor 6 Jahren von einem Neonazi ermordet. Der Mörder des CDU-Regierungspräsidenten von Kassel war u.a. bei #AfD aktiv und fasste den Tatplan nach AfD- und Neonazi-Mobilisierungen in #Chemnitz 2018.
Weil er öffentlich für Menschrechte von Geflüchteten einstand, wurde Walter Lübcke heute vor 6 Jahren von einem Neonazi ermordet. Der Mörder des CDU-Regierungspräsidenten von Kassel war u.a. bei #AfD aktiv und fasste den Tatplan nach AfD- und Neonazi-Mobilisierungen in #Chemnitz 2018.
Reposted by Sascha Kuhn
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
May 29, 2025 at 3:29 PM
E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable.
Read more: e11.bio/blog/volara
Reposted by Sascha Kuhn
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
May 13, 2025 at 8:40 AM
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
Reposted by Sascha Kuhn
How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation.
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
April 9, 2025 at 2:12 PM
How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation.
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social
Reposted by Sascha Kuhn
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 31, 2025 at 10:28 AM
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sascha Kuhn
My lab has a tradition that each week one person contributes edits to a Wikipedia page relevant to their scientific work, and then presents it briefly at lab meeting (and we clap). A few of my favorites:
en.wikipedia.org/wiki/Proprio...
en.wikipedia.org/wiki/Chionea
en.wikipedia.org/wiki/Femoral...
en.wikipedia.org/wiki/Proprio...
en.wikipedia.org/wiki/Chionea
en.wikipedia.org/wiki/Femoral...
Proprioception - Wikipedia
en.wikipedia.org
January 23, 2025 at 5:17 PM
My lab has a tradition that each week one person contributes edits to a Wikipedia page relevant to their scientific work, and then presents it briefly at lab meeting (and we clap). A few of my favorites:
en.wikipedia.org/wiki/Proprio...
en.wikipedia.org/wiki/Chionea
en.wikipedia.org/wiki/Femoral...
en.wikipedia.org/wiki/Proprio...
en.wikipedia.org/wiki/Chionea
en.wikipedia.org/wiki/Femoral...
Reposted by Sascha Kuhn
Full spectrum of ‘zebrabow’ embryos. Credit to @jhenninger.bsky.social. #ZebrafishZunday 🧪
December 15, 2024 at 1:25 PM
Full spectrum of ‘zebrabow’ embryos. Credit to @jhenninger.bsky.social. #ZebrafishZunday 🧪
Reposted by Sascha Kuhn
I love seeing so many interesting papers on Bluesky and my reading list keeps growing. So I would like to share a thread about our paper from this year. It was published when we were still at *the other place*, and I didn't feel like writing about it there.
www.science.org/doi/full/10....
1/n
www.science.org/doi/full/10....
1/n
December 11, 2024 at 10:29 AM
I love seeing so many interesting papers on Bluesky and my reading list keeps growing. So I would like to share a thread about our paper from this year. It was published when we were still at *the other place*, and I didn't feel like writing about it there.
www.science.org/doi/full/10....
1/n
www.science.org/doi/full/10....
1/n
Reposted by Sascha Kuhn
This cover came out when I was 14 but I never heard it.
It's hard to explain but I somehow I feel like it would have changed the course of my life if I had.
It's hard to explain but I somehow I feel like it would have changed the course of my life if I had.
The Rave-Ups - You Ain't Goin' Nowhere
YouTube video by standingathwart
www.youtube.com
December 6, 2024 at 8:19 AM
This cover came out when I was 14 but I never heard it.
It's hard to explain but I somehow I feel like it would have changed the course of my life if I had.
It's hard to explain but I somehow I feel like it would have changed the course of my life if I had.
Reposted by Sascha Kuhn
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
Reposted by Sascha Kuhn
And what better introduction than to share a new publication? Check out this review article I’ve been working on (along with my co-first authors) if you need a biosensor or want a comprehensive overview of the field. Now out as an ASAP article at Chemical Reviews! doi.org/10.1021/acs....
Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals
Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled the study of these signaling pathways ...
doi.org
November 14, 2024 at 11:56 PM
And what better introduction than to share a new publication? Check out this review article I’ve been working on (along with my co-first authors) if you need a biosensor or want a comprehensive overview of the field. Now out as an ASAP article at Chemical Reviews! doi.org/10.1021/acs....