Sarah Snelling
@sarahsnelling.bsky.social
University of Oxford | Transcriptomics | Musculoskeletal development, growth and pathology 🦴 | Sarcoma | Inflammation | Fibrosis | Biomaterials
Skier ⛷️, Runner, Mum and inept mountain biker
Skier ⛷️, Runner, Mum and inept mountain biker
Reposted by Sarah Snelling
We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair.
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon
Tendons are transitional tissues linking muscle to bone, enabling locomotion and fine motor control. The cellular biology across the Achilles tendon unit is poorly understood, yet critical for interpr...
www.biorxiv.org
October 30, 2025 at 11:18 AM
We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair.
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
Find our more in our new preprint www.biorxiv.org/content/10.1...
#Tendon #CellAtlas #SpatialTranscriptomics
Reposted by Sarah Snelling
Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.
physoc.onlinelibrary.wiley.com
July 21, 2025 at 4:55 PM
Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.
Reposted by Sarah Snelling
Dr Sarah Snelling @sarahsnelling.bsky.social is leading a new study aiming to develop a blood test that could identify markers of osteosarcoma. This could be game-changing for early detection of this disease.
May 30, 2025 at 9:02 AM
Dr Sarah Snelling @sarahsnelling.bsky.social is leading a new study aiming to develop a blood test that could identify markers of osteosarcoma. This could be game-changing for early detection of this disease.
Reposted by Sarah Snelling
Annemarie’s latest paper is out today!
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair - npj Regenerative Medicine
npj Regenerative Medicine - CYR61 delivery promotes angiogenesis during bone fracture repair
www.nature.com
April 24, 2025 at 3:15 AM
Annemarie’s latest paper is out today!
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
Fibroblasts & endothelial cells appear to orchestrate the early response to injury in ruptured quads tendons.
Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
April 24, 2025 at 1:49 PM
Fibroblasts & endothelial cells appear to orchestrate the early response to injury in ruptured quads tendons.
Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Join us online for the @humancellatlas.bsky.social Musculoskeletal Bionetwork seminar on 21st May at 4pm GMT. We're excited to hear about spatial mechano-transcriptomics from Dr Adrien Hallou @halloulab.bsky.social
Open to all interested in MSK atlases in any species!
Register now bit.ly/4jhakA8
Open to all interested in MSK atlases in any species!
Register now bit.ly/4jhakA8
April 23, 2025 at 2:35 PM
Join us online for the @humancellatlas.bsky.social Musculoskeletal Bionetwork seminar on 21st May at 4pm GMT. We're excited to hear about spatial mechano-transcriptomics from Dr Adrien Hallou @halloulab.bsky.social
Open to all interested in MSK atlases in any species!
Register now bit.ly/4jhakA8
Open to all interested in MSK atlases in any species!
Register now bit.ly/4jhakA8
Reposted by Sarah Snelling
Ever torn a tendon? Our study led by @joletmimpen.bsky.social discovered changes in fibroblast and immune cell populations that occur in quadriceps tendon tears.
Read more: doi.org/10.1113/JP28...
@sarahsnelling.bsky.social
@adamcribbs.bsky.social
Read more: doi.org/10.1113/JP28...
@sarahsnelling.bsky.social
@adamcribbs.bsky.social
April 16, 2025 at 8:47 AM
Ever torn a tendon? Our study led by @joletmimpen.bsky.social discovered changes in fibroblast and immune cell populations that occur in quadriceps tendon tears.
Read more: doi.org/10.1113/JP28...
@sarahsnelling.bsky.social
@adamcribbs.bsky.social
Read more: doi.org/10.1113/JP28...
@sarahsnelling.bsky.social
@adamcribbs.bsky.social
Calling clinicians, research nurses, lab scientists & bioinformaticians!
Please fill out our short survey on challenges & enablers for #biobanks & #Omics research.
Respondents from #GlobalSouth & #LMICs especially welcome!
@ndorms.bsky.social @humancellatlas.org
bit.ly/41nHHex
Please fill out our short survey on challenges & enablers for #biobanks & #Omics research.
Respondents from #GlobalSouth & #LMICs especially welcome!
@ndorms.bsky.social @humancellatlas.org
bit.ly/41nHHex
Biobanks and 'Omics amongst international clinicians and researchers
bit.ly
March 26, 2025 at 3:19 PM
Calling clinicians, research nurses, lab scientists & bioinformaticians!
Please fill out our short survey on challenges & enablers for #biobanks & #Omics research.
Respondents from #GlobalSouth & #LMICs especially welcome!
@ndorms.bsky.social @humancellatlas.org
bit.ly/41nHHex
Please fill out our short survey on challenges & enablers for #biobanks & #Omics research.
Respondents from #GlobalSouth & #LMICs especially welcome!
@ndorms.bsky.social @humancellatlas.org
bit.ly/41nHHex
Reposted by Sarah Snelling
Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
March 13, 2025 at 3:33 AM
Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Sarah Snelling
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
www.biorxiv.org
March 5, 2025 at 8:28 AM
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social
www.biorxiv.org/content/10.1...
It had to be done!
I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!
I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!
December 3, 2024 at 11:01 PM
It had to be done!
I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!
I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!
Reposted by Sarah Snelling
I cannot think of anyone more deserving than Megan Killian (@megankillian.bsky.social) for the Community Council Chair on the ORS Board of Directors ballot 😍
Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇
t.co/h60xhz38NN
Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇
t.co/h60xhz38NN
November 25, 2024 at 8:55 PM
I cannot think of anyone more deserving than Megan Killian (@megankillian.bsky.social) for the Community Council Chair on the ORS Board of Directors ballot 😍
Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇
t.co/h60xhz38NN
Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇
t.co/h60xhz38NN
If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you!
boneandjoint.org.uk/Article/10.1...
boneandjoint.org.uk/Article/10.1...
December 3, 2024 at 1:15 PM
If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you!
boneandjoint.org.uk/Article/10.1...
boneandjoint.org.uk/Article/10.1...
Reposted by Sarah Snelling
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Reposted by Sarah Snelling
Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation!
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
Molecular and genetic characterization of sex-linked orange coat color in the domestic cat
The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...
www.biorxiv.org
November 29, 2024 at 3:08 AM
Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation!
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social
www.biorxiv.org/content/10.1...
Thinking of doing a DPhil/PhD? Then take a look at this!
www.ndorms.ox.ac.uk/news/blog/st...
The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team.
From my perspective it's hugely fun & I'm always learning!
www.ndorms.ox.ac.uk/news/blog/st...
The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team.
From my perspective it's hugely fun & I'm always learning!
Studying for a DPhil at NDORMS – from the perspective of a supervisor and a student!
We often hear that NDORMS is particularly strong in bringing together different research disciplines. Associate Professor Sarah Snelling and three of her current and former students share their experi...
www.ndorms.ox.ac.uk
November 27, 2024 at 10:33 AM
Thinking of doing a DPhil/PhD? Then take a look at this!
www.ndorms.ox.ac.uk/news/blog/st...
The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team.
From my perspective it's hugely fun & I'm always learning!
www.ndorms.ox.ac.uk/news/blog/st...
The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team.
From my perspective it's hugely fun & I'm always learning!
Reposted by Sarah Snelling
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds
The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...
www.biorxiv.org
November 26, 2024 at 4:35 PM
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Reposted by Sarah Snelling
Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg
November 19, 2024 at 3:04 PM
Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg
Reposted by Sarah Snelling
My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
Osteoarthritis year in review 2024: Biology
Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which
a substantial increase in knowledge has been achieved over the last year. It covers
many different topics, however, a ...
www.oarsijournal.com
November 21, 2024 at 12:33 PM
My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
Reposted by Sarah Snelling
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
November 21, 2024 at 1:27 AM
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)