Frank Zaucke
@fzaucke.bsky.social
Head of a reserach lab at the University Hospital Frankfurt, Goethe University. Interested in the role of the #cartilage and #bone #extracellular #matrix in common and rare skeletal diseases, in particular #osteoarthritis and #osteogenesis imperfecta
Reposted by Frank Zaucke
Our abstract this week comes from Chantal Fayad who is researching the role of FGF signalling in hypochondroplasia and ageing at @institutimagine.bsky.social with Prof Laurence Legeai-Mallet. Please contact Chantal if you'd like to know more! www.linkedin.com/in/chantal-f...
#MSCA_DN #FGF #ageing
#MSCA_DN #FGF #ageing
November 13, 2025 at 3:26 PM
Our abstract this week comes from Chantal Fayad who is researching the role of FGF signalling in hypochondroplasia and ageing at @institutimagine.bsky.social with Prof Laurence Legeai-Mallet. Please contact Chantal if you'd like to know more! www.linkedin.com/in/chantal-f...
#MSCA_DN #FGF #ageing
#MSCA_DN #FGF #ageing
Reposted by Frank Zaucke
This week's abstract is by Matteo Signor who is studying the link between the ageing autonomic nervous system and IVD degeneration, supervised by @zsuzsajenei-lanzl.bsky.social at @goetheuni.bsky.social. Send Matteo a message to find out more! www.linkedin.com/in/matteo-si...
#IVD #ageing #MSCA_DN
#IVD #ageing #MSCA_DN
November 6, 2025 at 9:27 PM
This week's abstract is by Matteo Signor who is studying the link between the ageing autonomic nervous system and IVD degeneration, supervised by @zsuzsajenei-lanzl.bsky.social at @goetheuni.bsky.social. Send Matteo a message to find out more! www.linkedin.com/in/matteo-si...
#IVD #ageing #MSCA_DN
#IVD #ageing #MSCA_DN
Reposted by Frank Zaucke
Our next @change-ecm.bsky.social abstract is by Giulio Gatto, a PhD candidate from @goetheuni.bsky.social. Giulio is investigating OA-associated changes in cartilage ECM under the supervision of @fzaucke.bsky.social. Please message Giulio if you'd like to know more. www.linkedin.com/in/giulio-ga...
October 30, 2025 at 1:51 PM
Our next @change-ecm.bsky.social abstract is by Giulio Gatto, a PhD candidate from @goetheuni.bsky.social. Giulio is investigating OA-associated changes in cartilage ECM under the supervision of @fzaucke.bsky.social. Please message Giulio if you'd like to know more. www.linkedin.com/in/giulio-ga...
Fantastic line-up of speakers!
If you are interested in matrix research, please come to Heidelberg🤗
If you are interested in matrix research, please come to Heidelberg🤗
While we update our website regarding #DGMB2026, you can find a list of confirmed speakers here! 👇 We are so happy to have them and already look forward to lots of exciting science!
#ECRs, we'll have a pre-meeting together with the #EU-CHANGE network - more info coming soon! #ECM #MatrixBiology
#ECRs, we'll have a pre-meeting together with the #EU-CHANGE network - more info coming soon! #ECM #MatrixBiology
September 11, 2025 at 10:29 AM
Fantastic line-up of speakers!
If you are interested in matrix research, please come to Heidelberg🤗
If you are interested in matrix research, please come to Heidelberg🤗
The final version of our recent review on challenges in the development of DMOADs is available here👍
#osteaorthritis
rdcu.be/eAflJ
#osteaorthritis
rdcu.be/eAflJ
Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs – a more refined perspective
rdcu.be
August 11, 2025 at 2:24 PM
The final version of our recent review on challenges in the development of DMOADs is available here👍
#osteaorthritis
rdcu.be/eAflJ
#osteaorthritis
rdcu.be/eAflJ
Reposted by Frank Zaucke
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
July 16, 2025 at 8:59 AM
Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Great meeting! Hope to see many of you there👇
📣SAVE THE DATE!
#DGMB2026 will be held 15th-17th April 2026 in beautiful Heidelberg! More details to follow soon!
We will also have a satellite meeting for #EarlyCareerResearchers before the main meeting, giving you a chance to meet other #ECRs and make new conference-friends! #matrixbiology
#DGMB2026 will be held 15th-17th April 2026 in beautiful Heidelberg! More details to follow soon!
We will also have a satellite meeting for #EarlyCareerResearchers before the main meeting, giving you a chance to meet other #ECRs and make new conference-friends! #matrixbiology
June 16, 2025 at 3:38 PM
Great meeting! Hope to see many of you there👇
Reposted by Frank Zaucke
🚨 1 Milliarde Euro würde fehlen – was bedeutet das für Forschung & Lehre an hessischen #Hochschulen? Unser Präsident Prof. Dr. Enrico Schleiff findet klare Worte zum aktuellen Entwurf des Hochschulpakts. Jetzt ansehen und teilen! #Hochschulpakt #GoetheUni #Hessen
June 13, 2025 at 11:51 AM
🚨 1 Milliarde Euro würde fehlen – was bedeutet das für Forschung & Lehre an hessischen #Hochschulen? Unser Präsident Prof. Dr. Enrico Schleiff findet klare Worte zum aktuellen Entwurf des Hochschulpakts. Jetzt ansehen und teilen! #Hochschulpakt #GoetheUni #Hessen
Please have a look at this recent review on #osteoarthritis.
Thanks to Mario Rothbauer and the entire team for letting me contribute!
rdcu.be/epH7q
Thanks to Mario Rothbauer and the entire team for letting me contribute!
rdcu.be/epH7q
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research | Arthritis Research & Therapy
rdcu.be
June 6, 2025 at 9:18 AM
Please have a look at this recent review on #osteoarthritis.
Thanks to Mario Rothbauer and the entire team for letting me contribute!
rdcu.be/epH7q
Thanks to Mario Rothbauer and the entire team for letting me contribute!
rdcu.be/epH7q
Excited to share our latest work on a novel mutation in a gene that causes non-classical OI👇
url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480
url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480
May 14, 2025 at 1:47 PM
Excited to share our latest work on a novel mutation in a gene that causes non-classical OI👇
url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480
url:https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziaf083/8128480
Please have a look at and enjoy reading the latest publication I have contributed to😉
April 1, 2025 at 10:11 AM
Please have a look at and enjoy reading the latest publication I have contributed to😉
Now, the same group (including myself😉) presents data on how other cartilage biomarkers are changed as a result of immobilization.
Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...
Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...
Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals
To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartil…
www.sciencedirect.com
March 12, 2025 at 3:22 PM
Now, the same group (including myself😉) presents data on how other cartilage biomarkers are changed as a result of immobilization.
Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...
Immobilization by 21-days of bed rest causes changes in biomarkers of ... www.sciencedirect.com/science/arti...
In 2024, the effect of immobilization (by a 21 day bed rest) on the degradation of collagen II was published in the journal Osteoarthritis and Cartilage by Liphardt et al.
Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...
Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals
To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker…
www.sciencedirect.com
March 12, 2025 at 3:19 PM
In 2024, the effect of immobilization (by a 21 day bed rest) on the degradation of collagen II was published in the journal Osteoarthritis and Cartilage by Liphardt et al.
Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...
Immobilization by 21 days of bed rest results in type II collagen degr... www.sciencedirect.com/science/arti...
Honoured to be invited to such a fantastic meeting!
February 28, 2025 at 8:07 AM
Honoured to be invited to such a fantastic meeting!
I'll be there👇😉
You’re invited to one of the most anticipated events of #ORS2025, the JOR Editorial Recognition Dinner and Networking Reception. Join us for an evening of celebration, networking, and fun. Registration required. Learn more and register now: bit.ly/4g9rwGd
January 22, 2025 at 11:34 AM
I'll be there👇😉
With the following link
authors.elsevier.com/c/1kPnD3Im5h...
you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.
authors.elsevier.com/c/1kPnD3Im5h...
you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.
January 16, 2025 at 8:00 AM
With the following link
authors.elsevier.com/c/1kPnD3Im5h...
you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.
authors.elsevier.com/c/1kPnD3Im5h...
you have free access (for 50 days) to a recent study that our lab contributed to. We thank the lead authors for involving in this exciting project.
Amazing study!👇
Big congratulations to Shauni Loopmans for her excellent PhD research, now online in @natmetabolism.bsky.social. This study reveals that the pentose phosphate pathway in #chondrocytes is crucial for ER redox homeostasis and cell survival rdcu.be/d5Q65 (1/3)
The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes
Nature Metabolism - Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.
rdcu.be
January 14, 2025 at 7:24 AM
Amazing study!👇
In case you are interested in the role of the #ECM in inherited skeletal disorders other than #osteogenesis imperfecta like e.g. #Marfan or #Ehlers-Danlos, #achondroplasia, #ciliopathies: watch out for this book that will be published soon (January 2025)!
December 17, 2024 at 12:19 PM
In case you are interested in the role of the #ECM in inherited skeletal disorders other than #osteogenesis imperfecta like e.g. #Marfan or #Ehlers-Danlos, #achondroplasia, #ciliopathies: watch out for this book that will be published soon (January 2025)!
A very dark bluesky yesterday evening in Frankfurt
November 27, 2024 at 3:12 PM
A very dark bluesky yesterday evening in Frankfurt
A more detailled summary of my research interests/activities....generated here: scholargoggler.com
November 22, 2024 at 9:37 AM
A more detailled summary of my research interests/activities....generated here: scholargoggler.com
My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
Osteoarthritis year in review 2024: Biology
Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which
a substantial increase in knowledge has been achieved over the last year. It covers
many different topics, however, a ...
www.oarsijournal.com
November 21, 2024 at 12:33 PM
My first post on bsky☺️
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...
The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage
www.oarsijournal.com/article/S106...