Samuel Zambrano
@samuzambrano.bsky.social
Somewhere between physics and biology.
Interested in Dynamical Systems (in) Biology.
Physically at San Raffaele Univesity, Milan.
https://sites.google.com/view/dynamical-systems-in-biology/
https://www.unisr.it/en/docenti/z/zambrano-silva-samuel
Interested in Dynamical Systems (in) Biology.
Physically at San Raffaele Univesity, Milan.
https://sites.google.com/view/dynamical-systems-in-biology/
https://www.unisr.it/en/docenti/z/zambrano-silva-samuel
Pinned
Samuel Zambrano
@samuzambrano.bsky.social
· Oct 23
Frontiers | Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges
Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate ...
www.frontiersin.org
Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...
Reposted by Samuel Zambrano
Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases.
www.sciencedirect.com/science/arti...
#ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐
🧵 1/
www.sciencedirect.com/science/arti...
#ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐
🧵 1/
November 23, 2025 at 12:00 PM
Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases.
www.sciencedirect.com/science/arti...
#ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐
🧵 1/
www.sciencedirect.com/science/arti...
#ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐
🧵 1/
Halloween is a nice day to share our new site, where you can find more info on what our team does. It can briefly be summarized as Dynamical Systems (in) Biology: sites.google.com/view/dynamic...
Dynamical Systems (in) Biology
We are a team interested in (nonlinear) dynamical systems, in cell biology, in systems biology and in combinations of these elements.
Here you can learn about us, who we are, what we publish, how to c...
sites.google.com
October 31, 2025 at 3:30 PM
Halloween is a nice day to share our new site, where you can find more info on what our team does. It can briefly be summarized as Dynamical Systems (in) Biology: sites.google.com/view/dynamic...
Reposted by Samuel Zambrano
How do dynamics of signalling molecules skew cell fate decisions? With this review we try to move our first steps in the signalling dynamics field, together with the expert lead of @samuzambrano.bsky.social! Kudos to Fulvio, Sara and Erika for their excellent work!
Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...
Frontiers | Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges
Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate ...
www.frontiersin.org
October 23, 2025 at 6:02 PM
How do dynamics of signalling molecules skew cell fate decisions? With this review we try to move our first steps in the signalling dynamics field, together with the expert lead of @samuzambrano.bsky.social! Kudos to Fulvio, Sara and Erika for their excellent work!
Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...
Frontiers | Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges
Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate ...
www.frontiersin.org
October 23, 2025 at 7:41 AM
Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...
Reposted by Samuel Zambrano
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
DB-OTO Gene Therapy for Inherited Deafness | NEJM
Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...
www.nejm.org
October 12, 2025 at 2:19 PM
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
Reposted by Samuel Zambrano
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936
royalsocietypublishing.org
October 2, 2025 at 9:04 AM
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
Reposted by Samuel Zambrano
How do you prevent cacio e pepe sauce from congealing? A thoroughly researched answer earned its authors a prize!
Pasta Physics Scoops Up an Ig Nobel Prize
A group of Italian physicists was awarded the Ig Nobel Prize in Physics for their study of the phase diagram of a cheesy sauce renowned in Italy.
physics.aps.org
September 19, 2025 at 6:15 PM
How do you prevent cacio e pepe sauce from congealing? A thoroughly researched answer earned its authors a prize!
Reposted by Samuel Zambrano
I wrote a response to Thomas Friedman's "magical thinking" on AI here: aiguide.substack.com/p/magical-th...
September 15, 2025 at 4:27 PM
I wrote a response to Thomas Friedman's "magical thinking" on AI here: aiguide.substack.com/p/magical-th...
Reposted by Samuel Zambrano
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Sixty Years of Discovery | Annual Reviews
Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have ch...
www.annualreviews.org
September 8, 2025 at 1:43 AM
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Samuel Zambrano
Our @ourworldindata.org we visualise weekly updates of wildfire data from the Global Wildfire Information System.
Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years.
You can track this data here:
ourworldindata.org/wildfires
Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years.
You can track this data here:
ourworldindata.org/wildfires
August 22, 2025 at 11:31 AM
Our @ourworldindata.org we visualise weekly updates of wildfire data from the Global Wildfire Information System.
Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years.
You can track this data here:
ourworldindata.org/wildfires
Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years.
You can track this data here:
ourworldindata.org/wildfires
Reposted by Samuel Zambrano
My new @science.org editorial on the role of scientists in defending democracy is out today. As authoritarianism takes hold in the US, we must fight for the democratic principles that enable a free society and scientists have a key role. I hope you'll join us.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Scientists’ role in defending democracy
The United States’ democratic leadership, commitment to freedom of expression, and investment in the pursuit of knowledge have long enabled its preeminence in science and technology. Yet today we are ...
www.science.org
August 14, 2025 at 6:36 PM
My new @science.org editorial on the role of scientists in defending democracy is out today. As authoritarianism takes hold in the US, we must fight for the democratic principles that enable a free society and scientists have a key role. I hope you'll join us.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Samuel Zambrano
🎯
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
August 14, 2025 at 10:48 AM
🎯
There is something harder than reviewing a manuscript: reviewing a very bad manuscript.
August 13, 2025 at 1:07 PM
There is something harder than reviewing a manuscript: reviewing a very bad manuscript.
Reposted by Samuel Zambrano
1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years.
Today's executive order includes a provision that will obliterate both functions.
Today's executive order includes a provision that will obliterate both functions.
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
www.whitehouse.gov
August 8, 2025 at 1:13 AM
1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years.
Today's executive order includes a provision that will obliterate both functions.
Today's executive order includes a provision that will obliterate both functions.
Reposted by Samuel Zambrano
Carrying on with Session 4 on #EMBLSingleMolecule Day 3 🤓💪🏼
➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data'
🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology
@molinalab.bsky.social @igbmc.bsky.social @embl.org
➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data'
🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology
@molinalab.bsky.social @igbmc.bsky.social @embl.org
July 17, 2025 at 10:31 AM
Carrying on with Session 4 on #EMBLSingleMolecule Day 3 🤓💪🏼
➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data'
🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology
@molinalab.bsky.social @igbmc.bsky.social @embl.org
➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data'
🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology
@molinalab.bsky.social @igbmc.bsky.social @embl.org
Reposted by Samuel Zambrano
I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
July 3, 2025 at 1:10 PM
I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
Reposted by Samuel Zambrano
My chart on the history of three infectious diseases — smallpox, polio, and measles — before and after a vaccine was available.
June 26, 2025 at 9:40 PM
My chart on the history of three infectious diseases — smallpox, polio, and measles — before and after a vaccine was available.
Reposted by Samuel Zambrano
A new theoretical analysis directly links Nernst's theorem to the second law of thermodynamics, correcting a longstanding interpretation and clarifying the inaccessibility of absolute zero. doi.org/g9qkq3
Thermodynamics revisited: Study solves 120-year-old problem and corrects one of Einstein's ideas
Nernst's theorem—a general experimental observation presented in 1905 that entropy exchanges tend to zero when the temperature tends to zero—has been directly linked to the second principle of thermodynamics in a paper published in The European Physical Journal Plus, whose sole author is University of Seville professor José Martín-Olalla.
phys.org
June 17, 2025 at 8:57 PM
A new theoretical analysis directly links Nernst's theorem to the second law of thermodynamics, correcting a longstanding interpretation and clarifying the inaccessibility of absolute zero. doi.org/g9qkq3
Reposted by Samuel Zambrano
"We thank the reviewers for their helpful comments"
May 31, 2025 at 12:56 PM
"We thank the reviewers for their helpful comments"
Reposted by Samuel Zambrano
A must read!
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
May 30, 2025 at 10:38 AM
A must read!
This looks so cool: intracellular coupling of HES oscillators. Congrats Nancy and all the co-authors!
In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif
Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, ev...
www.biorxiv.org
May 29, 2025 at 8:02 PM
This looks so cool: intracellular coupling of HES oscillators. Congrats Nancy and all the co-authors!
Reposted by Samuel Zambrano
No doubt, this is one of the most exciting meetings of the year! And we will present our new method, HiddenFoot 😉: www.biorxiv.org/content/10.1...
‼️Last chance to join us in person for #EMBLSingleMolecule! Attend talks, network, socialise, and experience the atmosphere on the campus 🤩
🎫 Register by 3 Jun 👉🏼 http://s.embl.org/grg25-01-bl
🧬RNA processing
🧬Translation
🧬Transcription & chromatin regulation
🧬Method development
🧬Theory
🎫 Register by 3 Jun 👉🏼 http://s.embl.org/grg25-01-bl
🧬RNA processing
🧬Translation
🧬Transcription & chromatin regulation
🧬Method development
🧬Theory
May 28, 2025 at 9:45 PM
No doubt, this is one of the most exciting meetings of the year! And we will present our new method, HiddenFoot 😉: www.biorxiv.org/content/10.1...
Reposted by Samuel Zambrano
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
May 26, 2025 at 4:32 AM
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Reposted by Samuel Zambrano
As the parent of a type-I diabetic, I would like to invite the ignorant piece of shit currently directing the FDA to kiss my ass.
May 26, 2025 at 4:09 AM
As the parent of a type-I diabetic, I would like to invite the ignorant piece of shit currently directing the FDA to kiss my ass.