Roman Kostyuchenko
@rpkostyuchenko.bsky.social
Developmental biologist interested in embryology, Evo-Devo, axial patterning, regeneration, germ cells and agametic reproduction
Reposted by Roman Kostyuchenko
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Roman Kostyuchenko
What happens if your asexual reproduction goes wrong? For instance, you can grow a head instead of a tail. But if you're a flatworm, it's not that bad - as we showed in our newest paper published in the Proceedings of the Royal Society B: tinyurl.com/4dnp2ffz
October 29, 2025 at 2:53 PM
What happens if your asexual reproduction goes wrong? For instance, you can grow a head instead of a tail. But if you're a flatworm, it's not that bad - as we showed in our newest paper published in the Proceedings of the Royal Society B: tinyurl.com/4dnp2ffz
Reposted by Roman Kostyuchenko
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
A toolkit for testing membrane-localising tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
October 23, 2025 at 8:16 AM
How can we see the cells that make up a living organism? Membrane-localising tags can drive fluorescent proteins to the cell's outer membrane, making their outlines visible. But the tags don't work well in all organisms. How do you find one for your species of interest? 🧵
Check our latest preprint
Check our latest preprint
Reposted by Roman Kostyuchenko
📢 The First Circular for the 15th International Polychaete Conference (IPC15) is out! Join us in Frankfurt, Germany • 27–31 July 2026
#IPC15 #Polychaetes #Annelida
polychaete-association.com/ipc15-frankf...
#IPC15 #Polychaetes #Annelida
polychaete-association.com/ipc15-frankf...
October 23, 2025 at 7:32 PM
📢 The First Circular for the 15th International Polychaete Conference (IPC15) is out! Join us in Frankfurt, Germany • 27–31 July 2026
#IPC15 #Polychaetes #Annelida
polychaete-association.com/ipc15-frankf...
#IPC15 #Polychaetes #Annelida
polychaete-association.com/ipc15-frankf...
Reposted by Roman Kostyuchenko
So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 1:17 PM
So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹
Reposted by Roman Kostyuchenko
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
October 15, 2025 at 8:53 PM
Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD
Reposted by Roman Kostyuchenko
Cell Proliferation and Morphogenetic Compartmentalization in the Phoronid Phoronopsis harmeri: Conserved and Derived Patterns https://www.biorxiv.org/content/10.1101/2025.09.19.677378v1
September 19, 2025 at 9:31 PM
Cell Proliferation and Morphogenetic Compartmentalization in the Phoronid Phoronopsis harmeri: Conserved and Derived Patterns https://www.biorxiv.org/content/10.1101/2025.09.19.677378v1
Reposted by Roman Kostyuchenko
New paper on the expression of the estrogen receptor in the marine polychaete, Capitella teleta!
Congrats to @andreamurillo.bsky.social on another paper from her PhD!
www.sciencedirect.com/science/arti...
Great collaboration with the Seaver lab!
Congrats to @andreamurillo.bsky.social on another paper from her PhD!
www.sciencedirect.com/science/arti...
Great collaboration with the Seaver lab!
September 22, 2025 at 8:09 PM
New paper on the expression of the estrogen receptor in the marine polychaete, Capitella teleta!
Congrats to @andreamurillo.bsky.social on another paper from her PhD!
www.sciencedirect.com/science/arti...
Great collaboration with the Seaver lab!
Congrats to @andreamurillo.bsky.social on another paper from her PhD!
www.sciencedirect.com/science/arti...
Great collaboration with the Seaver lab!
Reposted by Roman Kostyuchenko
Evolution’s eye game is wild, but mollusks take it to another level
CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess
It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates
rdcu.be/ezw0t
CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess
It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates
rdcu.be/ezw0t
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Nature Communications - Accorsi et al. show that the apple snail Pomacea canaliculata has eyes similar to humans and can fully regenerate them. They then developed genetic tools to establish these...
url.us.m.mimecastprotect.com
August 6, 2025 at 11:21 AM
Evolution’s eye game is wild, but mollusks take it to another level
CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess
It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates
rdcu.be/ezw0t
CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess
It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates
rdcu.be/ezw0t
Reposted by Roman Kostyuchenko
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
August 8, 2025 at 5:39 PM
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
Reposted by Roman Kostyuchenko
Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances!
www.science.org/doi/10.1126/...
Are animals of different sizes made of the same cell types?
Here’s an update of the main points and revision items
(with memes!)
Thread 👇🧵
www.science.org/doi/10.1126/...
Are animals of different sizes made of the same cell types?
Here’s an update of the main points and revision items
(with memes!)
Thread 👇🧵
May 7, 2025 at 7:01 PM
Proud to present the peer-reviewed version of our Cell Type Allometry paper, out today in Science Advances!
www.science.org/doi/10.1126/...
Are animals of different sizes made of the same cell types?
Here’s an update of the main points and revision items
(with memes!)
Thread 👇🧵
www.science.org/doi/10.1126/...
Are animals of different sizes made of the same cell types?
Here’s an update of the main points and revision items
(with memes!)
Thread 👇🧵
Reposted by Roman Kostyuchenko
Job Alert! We are recruiting one postdoc to work on spiralian embryos and their crazy polar lobes. More info about this HFSP-funded position on our website baronelab.org: scroll to the end, click on "this could be you"...start your adventure!
May 28, 2025 at 2:48 AM
Job Alert! We are recruiting one postdoc to work on spiralian embryos and their crazy polar lobes. More info about this HFSP-funded position on our website baronelab.org: scroll to the end, click on "this could be you"...start your adventure!
Comparative Regeneration Dynamics of Platynereis dumerilii and Pygospio elegans (Annelida): Morphological and Cellular Events doi.org/10.1002/jez....
Comparative Regeneration Dynamics of Platynereis dumerilii and Pygospio elegans (Annelida): Morphological and Cellular Events
We compared the morphological and histological events of regeneration in Platynereis dumerilii and Pygospio elegans. While P. elegans regenerates both head and tail, P. dumerilii regrows only the tai...
doi.org
April 30, 2025 at 7:58 AM
Comparative Regeneration Dynamics of Platynereis dumerilii and Pygospio elegans (Annelida): Morphological and Cellular Events doi.org/10.1002/jez....
Reposted by Roman Kostyuchenko
Unexpected role of β-catenin signaling in germ layer specification
In this 'Show and tell' post, @genikhovich.bsky.social and @tclebedeva.bsky.social tell us about their video of a GFP-β-catenin knock-in Nematostella embryo from their latest paper:
🎥 thenode.biologists.com/unexpected-r...
In this 'Show and tell' post, @genikhovich.bsky.social and @tclebedeva.bsky.social tell us about their video of a GFP-β-catenin knock-in Nematostella embryo from their latest paper:
🎥 thenode.biologists.com/unexpected-r...
March 31, 2025 at 3:49 PM
Unexpected role of β-catenin signaling in germ layer specification
In this 'Show and tell' post, @genikhovich.bsky.social and @tclebedeva.bsky.social tell us about their video of a GFP-β-catenin knock-in Nematostella embryo from their latest paper:
🎥 thenode.biologists.com/unexpected-r...
In this 'Show and tell' post, @genikhovich.bsky.social and @tclebedeva.bsky.social tell us about their video of a GFP-β-catenin knock-in Nematostella embryo from their latest paper:
🎥 thenode.biologists.com/unexpected-r...
Reposted by Roman Kostyuchenko
Paper alert! We are a little late but very proud of the team's latest study on the neurogenic functions of the Notch signalling pathway during #regeneration and posterior elongation in #platynereis. @ijmonod.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis
Notch signaling is an evolutionarily conserved pathway known to orchestrate neurogenesis by regulating the transition of progenitor cells to differentiated neurons and glia, as well as by directing ne...
www.biorxiv.org
March 24, 2025 at 3:58 PM
Paper alert! We are a little late but very proud of the team's latest study on the neurogenic functions of the Notch signalling pathway during #regeneration and posterior elongation in #platynereis. @ijmonod.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Roman Kostyuchenko
New insight on gonad morphogenesis ! Our new paper reveals how germ & somatic cells interact through TGF-Beta feedback loop to drive gonad morphogenesis in Hydractinia.
Check out the full paper in Science Advances !
tinyurl.com/245rw699
Check out the full paper in Science Advances !
tinyurl.com/245rw699
A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian
Cnidarian germ cells secrete TGF-β to induce gonad development, and gonads induce germ cells by activating Tfap2 in stem cells.
tinyurl.com
January 8, 2025 at 10:24 PM
New insight on gonad morphogenesis ! Our new paper reveals how germ & somatic cells interact through TGF-Beta feedback loop to drive gonad morphogenesis in Hydractinia.
Check out the full paper in Science Advances !
tinyurl.com/245rw699
Check out the full paper in Science Advances !
tinyurl.com/245rw699
Reposted by Roman Kostyuchenko
Happy to present the peer-reviewed version of our Hydractinia Cell Atlas paper out today in Nature Communications! As I presented this back when we were in “that other” social network, let me recap the basic findings and revision items in this thread:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality - Nature Communications
Here they generate a cell type atlas of the colonial cnidarian Hydractinia symbiolongicarpus, which reveals that distinct colony parts are mostly made from unique combinations of shared cell types, an...
www.nature.com
March 3, 2025 at 6:20 PM
Happy to present the peer-reviewed version of our Hydractinia Cell Atlas paper out today in Nature Communications! As I presented this back when we were in “that other” social network, let me recap the basic findings and revision items in this thread:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Roman Kostyuchenko
The revised version of our #platynereis #connectome paper is now out:
https://elifesciences.org/reviewed-preprints/97964
Cell-type-level annotation of the whole organisms, including synaptic and desmosomal connectomes. Can be explored with CATMAID here […]
[Original post on biologists.social]
https://elifesciences.org/reviewed-preprints/97964
Cell-type-level annotation of the whole organisms, including synaptic and desmosomal connectomes. Can be explored with CATMAID here […]
[Original post on biologists.social]
March 4, 2025 at 8:45 AM
The revised version of our #platynereis #connectome paper is now out:
https://elifesciences.org/reviewed-preprints/97964
Cell-type-level annotation of the whole organisms, including synaptic and desmosomal connectomes. Can be explored with CATMAID here […]
[Original post on biologists.social]
https://elifesciences.org/reviewed-preprints/97964
Cell-type-level annotation of the whole organisms, including synaptic and desmosomal connectomes. Can be explored with CATMAID here […]
[Original post on biologists.social]
Reposted by Roman Kostyuchenko
Our paper describing the second species of Micrognathozoa, Limnognathia desmeti, is out: doi.org/10.1098/rspb... - big thanks to all coauthors, to Willem H. De Smet for finding this species, and to the Villum Foundation a.o. for supporting this project!
February 19, 2025 at 3:06 PM
Our paper describing the second species of Micrognathozoa, Limnognathia desmeti, is out: doi.org/10.1098/rspb... - big thanks to all coauthors, to Willem H. De Smet for finding this species, and to the Villum Foundation a.o. for supporting this project!
The results of our study suggest involvement of ParaHox genes in whole-body patterning and/or in tissue remodeling during growth and asexual reproduction in annelids, and may be evidence of the functional diversification of duplicated genes. doi.org/10.3390/gene...
February 19, 2025 at 8:56 AM
The results of our study suggest involvement of ParaHox genes in whole-body patterning and/or in tissue remodeling during growth and asexual reproduction in annelids, and may be evidence of the functional diversification of duplicated genes. doi.org/10.3390/gene...
Reposted by Roman Kostyuchenko
If you like snowflakes, check our new preprint about axial patterning in brittle stars ⭐
We looked at the expression of anteroposterior patterning genes in Amphipholis squamata juveniles, and compared it with existing data from other classes
www.biorxiv.org/content/10.1...
@lowelab.bsky.social
We looked at the expression of anteroposterior patterning genes in Amphipholis squamata juveniles, and compared it with existing data from other classes
www.biorxiv.org/content/10.1...
@lowelab.bsky.social
February 17, 2025 at 5:32 PM
If you like snowflakes, check our new preprint about axial patterning in brittle stars ⭐
We looked at the expression of anteroposterior patterning genes in Amphipholis squamata juveniles, and compared it with existing data from other classes
www.biorxiv.org/content/10.1...
@lowelab.bsky.social
We looked at the expression of anteroposterior patterning genes in Amphipholis squamata juveniles, and compared it with existing data from other classes
www.biorxiv.org/content/10.1...
@lowelab.bsky.social
Reposted by Roman Kostyuchenko
Congrats to the 2025 SDB Award Winners!
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
February 11, 2025 at 5:08 PM
Congrats to the 2025 SDB Award Winners!
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap
In our study, we have shown that sexually reproducing annelids are able to establish germ cells and become fully sexually mature. We also have discovered that asexual propagation and germ cell/gonadal development/maturation are not mutually exclusive. doi.org/10.3390/jdb1...
Vasa, Piwi, and Pl10 Expression during Sexual Maturation and Asexual Reproduction in the Annelid Pristina longiseta
Naidids are tiny, transparent freshwater oligochaetes, which are well known for their ability to propagate asexually. Despite the fact that sexually mature individuals and cocoons with embryos are som...
doi.org
February 7, 2025 at 9:38 AM
In our study, we have shown that sexually reproducing annelids are able to establish germ cells and become fully sexually mature. We also have discovered that asexual propagation and germ cell/gonadal development/maturation are not mutually exclusive. doi.org/10.3390/jdb1...
Origin of the primordial germ cells in annelids: a combination of inherited cytoplasmic determinants, followed by inductive processes? Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus www.mdpi.com/2079-7737/12...
February 3, 2025 at 4:06 PM
Origin of the primordial germ cells in annelids: a combination of inherited cytoplasmic determinants, followed by inductive processes? Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus www.mdpi.com/2079-7737/12...