Rocio Enriquez-Gasca
@rocioeg.bsky.social
Postdoc at the Cardoso Moreira lab @Crick. Transposable Elements and data science enthusiast.
Reposted by Rocio Enriquez-Gasca
Handsup 🙌, who is coming to @blizardinstitute.bsky.social to attend the @illingworth-lab.bsky.social seminar this Friday on "polycomb repression in development and disease"? Also, who is joining online for this @qmulepigenetics.bsky.social seminar.
Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’.
To join, please follow this link: qmul.ac.uk/epigenetics/...
To join, please follow this link: qmul.ac.uk/epigenetics/...
September 9, 2025 at 9:06 AM
Handsup 🙌, who is coming to @blizardinstitute.bsky.social to attend the @illingworth-lab.bsky.social seminar this Friday on "polycomb repression in development and disease"? Also, who is joining online for this @qmulepigenetics.bsky.social seminar.
Reposted by Rocio Enriquez-Gasca
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis
Retrotransposons are mobile repetitive elements that constitute around 43% of the
human genome. Normally silenced through epigenetic mechanisms, retrotransposons can
become reactivated in response to ...
www.cell.com
September 3, 2025 at 5:02 AM
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reposted by Rocio Enriquez-Gasca
Today we’re introducing a major update to the family seed alignments, protein features, and relationship data visualizations on the Dfam website. In addition, we are adding two new datasets: ULTRA reported tandem repeats, and self-alignments.
Dfam Family Visualization Improvements
Today we’re introducing a major update to how TE family seed alignments, protein features, and relationship data are visualized on the Dfam website. Previously, these datasets were presented separa…
xfam.wordpress.com
August 6, 2025 at 8:56 PM
Today we’re introducing a major update to the family seed alignments, protein features, and relationship data visualizations on the Dfam website. In addition, we are adding two new datasets: ULTRA reported tandem repeats, and self-alignments.
Reposted by Rocio Enriquez-Gasca
Composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
August 7, 2025 at 9:43 PM
Composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Rocio Enriquez-Gasca
It's finally here! Great start of the summer. We got our latest preprint from @chemamd.bsky.social in @qmulsbbs.bsky.social @qmulse.bsky.social, showing evidence of developmental system drift in the specification of dorsoventral (belly vs back) axis in annelids 🪱🪱🪱
#DevBio #EvoDevo
#DevBio #EvoDevo
June 2, 2025 at 9:14 AM
It's finally here! Great start of the summer. We got our latest preprint from @chemamd.bsky.social in @qmulsbbs.bsky.social @qmulse.bsky.social, showing evidence of developmental system drift in the specification of dorsoventral (belly vs back) axis in annelids 🪱🪱🪱
#DevBio #EvoDevo
#DevBio #EvoDevo
Reposted by Rocio Enriquez-Gasca
In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis.
Learn more here:
➡️ tinyurl.com/gd352270
Learn more here:
➡️ tinyurl.com/gd352270
April 22, 2025 at 8:00 PM
In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis.
Learn more here:
➡️ tinyurl.com/gd352270
Learn more here:
➡️ tinyurl.com/gd352270
Reposted by Rocio Enriquez-Gasca
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rocio Enriquez-Gasca
Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c...
1/3
1/3
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
April 2, 2025 at 6:30 PM
Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c...
1/3
1/3
Reposted by Rocio Enriquez-Gasca
Join us on 4th of June at our Centre of Epigenetics Launch Conference where @mpercharde.bsky.social will present the latest work from her lab. #TEworldwide
Only a couple of months left until our official QMUL Centre for Epigenetics Launch Conference! We will have an amazing list of guest speakers, including Michelle Percharde @mpercharde.bsky.social from MRC LMS, UK. Spaces are limited.
March 26, 2025 at 1:27 PM
Join us on 4th of June at our Centre of Epigenetics Launch Conference where @mpercharde.bsky.social will present the latest work from her lab. #TEworldwide
Reposted by Rocio Enriquez-Gasca
Check out our preprint "De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in Preeclampsia" www.researchsquare.com/article/rs-6...
March 26, 2025 at 10:08 AM
Check out our preprint "De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in Preeclampsia" www.researchsquare.com/article/rs-6...
Reposted by Rocio Enriquez-Gasca
🚨Registration for the UK #EvoDevo meeting is open! Join us on July 11th in London to enjoy an exciting day of talks, posters, friends, and superb science!
-Registration (only £5!): shorturl.at/9cQGL
-More info: londonevodevo.ac.uk
-Registration (only £5!): shorturl.at/9cQGL
-More info: londonevodevo.ac.uk
March 25, 2025 at 2:40 PM
🚨Registration for the UK #EvoDevo meeting is open! Join us on July 11th in London to enjoy an exciting day of talks, posters, friends, and superb science!
-Registration (only £5!): shorturl.at/9cQGL
-More info: londonevodevo.ac.uk
-Registration (only £5!): shorturl.at/9cQGL
-More info: londonevodevo.ac.uk
Reposted by Rocio Enriquez-Gasca
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
March 9, 2025 at 2:35 AM
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
Reposted by Rocio Enriquez-Gasca
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
March 16, 2025 at 10:31 AM
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social
Reposted by Rocio Enriquez-Gasca
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
media.tenor.com
February 13, 2025 at 1:23 PM
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5
Reposted by Rocio Enriquez-Gasca
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
January 27, 2025 at 7:58 AM
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
Reposted by Rocio Enriquez-Gasca
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
Apply before Feb 15th
📌
November 28, 2024 at 7:21 PM
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
Apply before Feb 15th
📌
Reposted by Rocio Enriquez-Gasca
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Single cell – ENCODEHomo sapiens clickable body map
www.encodeproject.org
January 7, 2025 at 9:29 PM
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Reposted by Rocio Enriquez-Gasca
We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements.
www.genesdev.org/cgi/doi/10.1...
www.genesdev.org/cgi/doi/10.1...
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
www.genesdev.org
January 2, 2025 at 8:36 PM
We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements.
www.genesdev.org/cgi/doi/10.1...
www.genesdev.org/cgi/doi/10.1...
Reposted by Rocio Enriquez-Gasca
Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon https://www.biorxiv.org/content/10.1101/2024.12.14.628481v1
December 18, 2024 at 7:37 AM
Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon https://www.biorxiv.org/content/10.1101/2024.12.14.628481v1
Reposted by Rocio Enriquez-Gasca
#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
www.cell.com
December 12, 2024 at 5:36 PM
#NotOnlyParasites! 2 Cell papers by @edchuong.bsky.social lab & Amigorena lab demonstrate that transposable elements #TEs can exonize giving rise to functional (often shorter) proteins with distinct functions: eg a decoy short IFNAR2 that inhibits #interferon signaling! www.cell.com/cell/fulltex...
Reposted by Rocio Enriquez-Gasca
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Rocio Enriquez-Gasca
Do you need to curate a Transposable Elements library for a new genome 🧬 or a new species 🐜🦟🦖? Try MCHelper.!
Very proud of my (small) contribution here. Gracias a @simonorozcoa.bsky.social y @gonzalezlabbcn.bsky.social!
genome.cshlp.org/content/earl...
Very proud of my (small) contribution here. Gracias a @simonorozcoa.bsky.social y @gonzalezlabbcn.bsky.social!
genome.cshlp.org/content/earl...
genome.cshlp.org
December 13, 2024 at 9:02 AM
Do you need to curate a Transposable Elements library for a new genome 🧬 or a new species 🐜🦟🦖? Try MCHelper.!
Very proud of my (small) contribution here. Gracias a @simonorozcoa.bsky.social y @gonzalezlabbcn.bsky.social!
genome.cshlp.org/content/earl...
Very proud of my (small) contribution here. Gracias a @simonorozcoa.bsky.social y @gonzalezlabbcn.bsky.social!
genome.cshlp.org/content/earl...
Reposted by Rocio Enriquez-Gasca
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
December 1, 2024 at 12:30 PM
Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.
Reposted by Rocio Enriquez-Gasca
Well done paper from Wenfeng An's lab showing Yy1 activates L1 TF monomers but surprisingly not GF monomers. More monomers = stronger Yy1 activation
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
YY1 is a transcriptional activator of the mouse LINE-1 Tf subfamily
Abstract. Long interspersed element type 1 (LINE-1, L1) is an active autonomous transposable element in human and mouse genomes. L1 transcription is contro
academic.oup.com
November 23, 2024 at 12:06 AM
Well done paper from Wenfeng An's lab showing Yy1 activates L1 TF monomers but surprisingly not GF monomers. More monomers = stronger Yy1 activation
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Rocio Enriquez-Gasca
Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬
Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome Biology
Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...
link.springer.com
November 18, 2024 at 5:50 PM
Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬