Andrea Rocha
@rochaandrea.bsky.social
Postdoc Researcher @salkinstitute. Metabolism│Immunology│Non-coding RNA│Microprotein - 🇧🇷
Pinned
Andrea Rocha
@rochaandrea.bsky.social
· Aug 29
Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice
A uORF-encoded microprotein, SLC35A4-MP, modulates mitochondrial morphology and function in brown adipose tissue.
www.science.org
Thrilled to share that our paper is finally out in Science Advances!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
Excited to see our work featured in the Salk news release! www.salk.edu/news-release...
Leveraging microproteins to treat obesity, aging, and mitochondrial disorders - Salk Institute for Biological Studies
LA JOLLA—Like bees breathing life into gardens, providing pollen and making flowers blossom, little cellular machines called mitochondria breathe life into our bodies, buzzing with energy as they prod...
www.salk.edu
August 29, 2025 at 11:31 PM
Excited to see our work featured in the Salk news release! www.salk.edu/news-release...
Thrilled to share that our paper is finally out in Science Advances!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice
A uORF-encoded microprotein, SLC35A4-MP, modulates mitochondrial morphology and function in brown adipose tissue.
www.science.org
August 29, 2025 at 8:23 PM
Thrilled to share that our paper is finally out in Science Advances!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! www.science.org/doi/10.1126/...
Reposted by Andrea Rocha
Ageing & leukemia reshape metabolism of hematopoietic stem and progenitor cells. Mapping lipidomic and metabolomic shifts in human bone marrow, spotlighting choline as a key player in stemness to restore physiology!
@natcellbio.nature.com @ninacabezas.bsky.social
doi.org/10.1038/s415... 🧪
@natcellbio.nature.com @ninacabezas.bsky.social
doi.org/10.1038/s415... 🧪
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells
Nature Cell Biology - Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia,...
doi.org
August 20, 2025 at 9:49 AM
Ageing & leukemia reshape metabolism of hematopoietic stem and progenitor cells. Mapping lipidomic and metabolomic shifts in human bone marrow, spotlighting choline as a key player in stemness to restore physiology!
@natcellbio.nature.com @ninacabezas.bsky.social
doi.org/10.1038/s415... 🧪
@natcellbio.nature.com @ninacabezas.bsky.social
doi.org/10.1038/s415... 🧪
Reposted by Andrea Rocha
Methods and applications of in vivo CRISPR screening
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Methods and applications of in vivo CRISPR screening - Nature Reviews Genetics
In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review outlines key criteria for understanding...
www.nature.com
July 29, 2025 at 7:01 PM
Methods and applications of in vivo CRISPR screening
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrea Rocha
Love this! Tumor cells with broken tRNA modifications create weird peptides that T-cells love to track down.
Translational dysregulation in cancer as a source for targetable antigens.
www.cell.com/cancer-cell/...
Translational dysregulation in cancer as a source for targetable antigens.
www.cell.com/cancer-cell/...
Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor
immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide
MHC presentation, increasin...
www.cell.com
April 1, 2025 at 2:40 AM
Love this! Tumor cells with broken tRNA modifications create weird peptides that T-cells love to track down.
Translational dysregulation in cancer as a source for targetable antigens.
www.cell.com/cancer-cell/...
Translational dysregulation in cancer as a source for targetable antigens.
www.cell.com/cancer-cell/...
Reposted by Andrea Rocha
Wow!
surprising new cell-intrinsic innate immune function in 𝘕𝘈𝘛𝘜𝘙𝘌
PROTEOSOMES generate antimicrobial peptides that kill bacteria as a first line of defense
bacterial infection alters proteasome function to boost this protective activity
are proteosomes a novel target for antimicrobial therapy?
surprising new cell-intrinsic innate immune function in 𝘕𝘈𝘛𝘜𝘙𝘌
PROTEOSOMES generate antimicrobial peptides that kill bacteria as a first line of defense
bacterial infection alters proteasome function to boost this protective activity
are proteosomes a novel target for antimicrobial therapy?
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 7, 2025 at 2:24 PM
Wow!
surprising new cell-intrinsic innate immune function in 𝘕𝘈𝘛𝘜𝘙𝘌
PROTEOSOMES generate antimicrobial peptides that kill bacteria as a first line of defense
bacterial infection alters proteasome function to boost this protective activity
are proteosomes a novel target for antimicrobial therapy?
surprising new cell-intrinsic innate immune function in 𝘕𝘈𝘛𝘜𝘙𝘌
PROTEOSOMES generate antimicrobial peptides that kill bacteria as a first line of defense
bacterial infection alters proteasome function to boost this protective activity
are proteosomes a novel target for antimicrobial therapy?
Reposted by Andrea Rocha
Can we perform genome-wide screens in any cell type in the body?! Excited to share our roadmap for leveraging advances in sgRNA delivery, library design, and phenotypic selection to enable unprecedented genetic dissection of organismal physiology and disease.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
A roadmap toward genome-wide CRISPR screening throughout the organism
Genome-wide CRISPR screening in the organism has tremendous potential to answer long-standing
questions of physiology and disease; however, technical limitations have prevented
its broad application. ...
www.cell.com
February 24, 2025 at 4:08 PM
Can we perform genome-wide screens in any cell type in the body?! Excited to share our roadmap for leveraging advances in sgRNA delivery, library design, and phenotypic selection to enable unprecedented genetic dissection of organismal physiology and disease.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Great review
A Review by Dan Tan and Alan Saghatelian discusses the development of methods to detect and characterize fatty acid esters of hydroxy fatty acids (FAHFAs), bioactive lipids linked to metabolic health and inflammation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The measurement, regulation and biological activity of FAHFAs - Nature Chemical Biology
This Review underscores the pivotal role of chemical biology in the discovery and characterization of fatty acid esters of hydroxy fatty acids, bioactive lipids linked to metabolic health and inflamma...
www.nature.com
January 28, 2025 at 5:43 PM
Great review