Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...

Nature Reviews Genetics, Published online: 30 June 2025; doi:10.1038/s41576-025-00862-xDisruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects arising from disruptions to the genome architecture.

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o