Beat Fierz
@beatfierz.bsky.social
Assoc Prof at EPFL, Chemical Biology and Biophysics, working in protein chemistry, peptides, epigenetics, chromatin, microtubules
Reposted by Beat Fierz
The work of Xingyu Liu @xingyuliu9595.bsky.social in collaboration with Wei Cai in Beat Fierz @beatfierz.bsky.social group @lcbm-epfl.bsky.social and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angewandtechemie.bsky.social !
doi.org/10.1002/anie...
doi.org/10.1002/anie...
June 5, 2025 at 6:57 PM
The work of Xingyu Liu @xingyuliu9595.bsky.social in collaboration with Wei Cai in Beat Fierz @beatfierz.bsky.social group @lcbm-epfl.bsky.social and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angewandtechemie.bsky.social !
doi.org/10.1002/anie...
doi.org/10.1002/anie...
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
May 21, 2025 at 6:59 PM
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Beat Fierz
I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳
April 4, 2025 at 12:28 PM
I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳
Reposted by Beat Fierz
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
February 4, 2025 at 1:13 PM
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
Don’t miss tomorrow's in-person #chembio seminar by Prof. Dr. Nina Hartrampf @ninahartrampf.bsky.social
👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
⏱️🇨🇭16:15 › 17:15
📢 bit.ly/3MOjVjy
👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
⏱️🇨🇭16:15 › 17:15
📢 bit.ly/3MOjVjy
Chemical Biology Seminar Series 3 (CH-637)
-
bit.ly
November 25, 2024 at 10:20 AM
Don’t miss tomorrow's in-person #chembio seminar by Prof. Dr. Nina Hartrampf @ninahartrampf.bsky.social
👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
⏱️🇨🇭16:15 › 17:15
📢 bit.ly/3MOjVjy
👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
⏱️🇨🇭16:15 › 17:15
📢 bit.ly/3MOjVjy
Reposted by Beat Fierz
Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @beatfierz.bsky.social @davidsuter.bsky.social
THX to the EMBL travel grant for me to attend such great conference #EMBLOmics
THX to the EMBL travel grant for me to attend such great conference #EMBLOmics
November 23, 2024 at 12:22 PM
Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @beatfierz.bsky.social @davidsuter.bsky.social
THX to the EMBL travel grant for me to attend such great conference #EMBLOmics
THX to the EMBL travel grant for me to attend such great conference #EMBLOmics
Reposted by Beat Fierz
🎖️ Yesterday PhD #Benjamin won a presentation price at the LS2 sub-section meeting – nice recognition for his careful #DyeCycling work! 🟢🔴🧬
Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing!
Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌
Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing!
Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌
November 21, 2024 at 9:37 AM
🎖️ Yesterday PhD #Benjamin won a presentation price at the LS2 sub-section meeting – nice recognition for his careful #DyeCycling work! 🟢🔴🧬
Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing!
Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌
Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing!
Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌
Reposted by Beat Fierz
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻
We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...
⏰ Application deadline = November 15
We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...
⏰ Application deadline = November 15
UZH: PhD Position in Solid-Phase Peptide Synthesis (Industry Collaboration)
A PhD position is available in the group of Prof. Dr. Nina Hartrampf at the Department of Chemistry, University of Zurich (Switzerland), in collaboration with the company Novo Nordisk in Måløv, Denmar...
jobs.uzh.ch
November 13, 2024 at 6:11 AM
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻
We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...
⏰ Application deadline = November 15
We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...
⏰ Application deadline = November 15
Reposted by Beat Fierz
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Chromatin regulation relies on "writer" enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which are...
www.biorxiv.org
November 1, 2024 at 11:29 AM
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Lots of movement on bsky, it’s getting lively!
November 9, 2024 at 5:41 PM
Lots of movement on bsky, it’s getting lively!
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Chromatin regulation relies on "writer" enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which are...
www.biorxiv.org
November 1, 2024 at 11:29 AM
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Check out the new review from @carlosmyruela.bsky.social on the using synthetic chromatin to investigate the function of histone deacylases! doi.org/10.1042/BST2...
January 9, 2024 at 6:21 PM
Check out the new review from @carlosmyruela.bsky.social on the using synthetic chromatin to investigate the function of histone deacylases! doi.org/10.1042/BST2...
Impressions from the LCBM Xmas party.!Happy holidays!!! 🎄🎁🎅🏽
December 16, 2023 at 5:15 PM
Impressions from the LCBM Xmas party.!Happy holidays!!! 🎄🎁🎅🏽
Check out our work on centro-chromatin, where CENP-A and CENP-B collaborate to generate a dynamic chromatin state! A great collaboration between Nikolina Sekulic’s lab & us, and the labs of Mario Halic and Tatsuo Fukagawa. Congrats Harsh and Ahmad! www.nature.com/articles/s41...
December 12, 2023 at 1:41 PM
Check out our work on centro-chromatin, where CENP-A and CENP-B collaborate to generate a dynamic chromatin state! A great collaboration between Nikolina Sekulic’s lab & us, and the labs of Mario Halic and Tatsuo Fukagawa. Congrats Harsh and Ahmad! www.nature.com/articles/s41...
The work of Xingyuu Liu and Jerome Waser, in collaboration with us and the Radenovic lab and funded within project SeleCHEM (ERC), on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in JACS! pubs.acs.org/doi/10.1021/...
December 1, 2023 at 7:30 AM
The work of Xingyuu Liu and Jerome Waser, in collaboration with us and the Radenovic lab and funded within project SeleCHEM (ERC), on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in JACS! pubs.acs.org/doi/10.1021/...
Are you a junior scientist 🏋️ in 🇨🇭#chembio, 🔎opportunities for lasting professional relationships & showcase your research? 🧪🔬 👉🏻 ask your PI to join the SNE #ChemBio network! 👉🏻 submit your request bit.ly/3QuphmC #ChemicalBiology #Networking #ChemBio
November 21, 2023 at 8:03 PM
Are you a junior scientist 🏋️ in 🇨🇭#chembio, 🔎opportunities for lasting professional relationships & showcase your research? 🧪🔬 👉🏻 ask your PI to join the SNE #ChemBio network! 👉🏻 submit your request bit.ly/3QuphmC #ChemicalBiology #Networking #ChemBio
Another exciting position at EPFL in Life Science Engineering, spanning the disciplines of: synthetic, systems and computational biology, cellular and tissue engineering, biomaterials, functional genomics, proteomics and metabolomics! Find the details here: www.epfl.ch/about/workin...
October 30, 2023 at 6:07 PM
Another exciting position at EPFL in Life Science Engineering, spanning the disciplines of: synthetic, systems and computational biology, cellular and tissue engineering, biomaterials, functional genomics, proteomics and metabolomics! Find the details here: www.epfl.ch/about/workin...
Congratulations to PhD student Arthur Despois for his poster prize at the joint posters exhibition of SCGC-EDCH! actu.epfl.ch/news/best-po...
October 6, 2023 at 4:12 PM
Congratulations to PhD student Arthur Despois for his poster prize at the joint posters exhibition of SCGC-EDCH! actu.epfl.ch/news/best-po...
We are hiring! We look for Postdocs in the field of biophysics / chemical biology of gene regulation within a context of a SNSF Advanced Grant starting in 2024! More details here: www.epfl.ch/schools/sb/r...
October 5, 2023 at 9:28 PM
We are hiring! We look for Postdocs in the field of biophysics / chemical biology of gene regulation within a context of a SNSF Advanced Grant starting in 2024! More details here: www.epfl.ch/schools/sb/r...
Are you developing new biosynthesis and/or green chemistry approaches? Here is a tenure track faculty position that might be of interest to you! There is less than a month left to apply for this position (deadline Oct 15)! So, apply here and join us at EPFL!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
October 3, 2023 at 1:19 PM
Are you developing new biosynthesis and/or green chemistry approaches? Here is a tenure track faculty position that might be of interest to you! There is less than a month left to apply for this position (deadline Oct 15)! So, apply here and join us at EPFL!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...