Rebsamen Lab @UNIL
@rebsamenlab.bsky.social
Research lab, Dpt. of Immunobiology, University of Lausanne, Switzerland. #InnateImmunity, #autoimmunity, #solutecarriers. Views are my own.
More info: www.rebsamenlab.org
More info: www.rebsamenlab.org
Pinned
The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications
TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...
www.nature.com
Excited to share our latest paper out today in @naturecomms.bsky.social !
Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.
#ImmunoSky #InterferoSky
Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.
#ImmunoSky #InterferoSky
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
October 1, 2025 at 7:51 AM
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social
#ImmunoSky
Reposted by Rebsamen Lab @UNIL
📣 Reminder 📣
There is still time to apply for this #job #opportunity in the field of #metabolic #diseases at the Department of Biomedical Sciences @fbm-unil.bsky.social @unil.bsky.social
👇👇👇
There is still time to apply for this #job #opportunity in the field of #metabolic #diseases at the Department of Biomedical Sciences @fbm-unil.bsky.social @unil.bsky.social
👇👇👇
📢 Applications open for a Tenure-track Assistant Professor towards Associate Professor in the field of #metabolic #diseases
📍 within the Department of Biomedical Sciences
❗ Apply before August 10th, 2025
More info 👉 wwwfbm.unil.ch/releve/appli...
#joboffer @unil.bsky.social
📍 within the Department of Biomedical Sciences
❗ Apply before August 10th, 2025
More info 👉 wwwfbm.unil.ch/releve/appli...
#joboffer @unil.bsky.social
DBS: Tenure-track Assistant Professor towards Associate Professor in the field of metabolic diseases - Site des postulations FBM
UNIL is a leading international teaching and research institution, with over 5,000 employees and 15,500 students split between its Dorigny campus, CHUV and Epalinges sites. As an employer, UNIL…
wwwfbm.unil.ch
July 21, 2025 at 7:30 AM
📣 Reminder 📣
There is still time to apply for this #job #opportunity in the field of #metabolic #diseases at the Department of Biomedical Sciences @fbm-unil.bsky.social @unil.bsky.social
👇👇👇
There is still time to apply for this #job #opportunity in the field of #metabolic #diseases at the Department of Biomedical Sciences @fbm-unil.bsky.social @unil.bsky.social
👇👇👇
Reposted by Rebsamen Lab @UNIL
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
May 19, 2025 at 10:46 AM
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
🚨 Abstract submission deadline: July 15th 2025🚨
Do not miss the opportunity to present your research: 10 selected short talks and an exciting poster session!
Register and submit your abstract here: wp.unil.ch/immunobiolog...
Do not miss the opportunity to present your research: 10 selected short talks and an exciting poster session!
Register and submit your abstract here: wp.unil.ch/immunobiolog...
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
July 3, 2025 at 7:06 AM
🚨 Abstract submission deadline: July 15th 2025🚨
Do not miss the opportunity to present your research: 10 selected short talks and an exciting poster session!
Register and submit your abstract here: wp.unil.ch/immunobiolog...
Do not miss the opportunity to present your research: 10 selected short talks and an exciting poster session!
Register and submit your abstract here: wp.unil.ch/immunobiolog...
Reposted by Rebsamen Lab @UNIL
Big congratulations to Cyrielle Hou (@dib-unil.bsky.social @fbm-unil.bsky.social) for receiving the Young Investigator Award at the 13th Meeting of the International Society of Systemic Autoinflammatory Diseases (ISSAID) in Paris! 🏆👏
And kudos to the organizers for a fantastic conference!
And kudos to the organizers for a fantastic conference!
April 11, 2025 at 11:31 AM
Big congratulations to Cyrielle Hou (@dib-unil.bsky.social @fbm-unil.bsky.social) for receiving the Young Investigator Award at the 13th Meeting of the International Society of Systemic Autoinflammatory Diseases (ISSAID) in Paris! 🏆👏
And kudos to the organizers for a fantastic conference!
And kudos to the organizers for a fantastic conference!
Reposted by Rebsamen Lab @UNIL
The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!
More info: www.unil.ch/news/1749042...
More info: www.unil.ch/news/1749042...
June 24, 2025 at 11:31 AM
The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!
More info: www.unil.ch/news/1749042...
More info: www.unil.ch/news/1749042...
Reposted by Rebsamen Lab @UNIL
We're looking forward to taking part in this meeting this October! JEM's Deputy Editor Gaia Trincucci (@gaiajexpmed.bsky.social) will be there – be sure to connect with Gaia to discuss your research and learn about publication 🔬💻✍️📄
#InnateImmunity #Immunobiology
#InnateImmunity #Immunobiology
June 10, 2025 at 2:27 PM
We're looking forward to taking part in this meeting this October! JEM's Deputy Editor Gaia Trincucci (@gaiajexpmed.bsky.social) will be there – be sure to connect with Gaia to discuss your research and learn about publication 🔬💻✍️📄
#InnateImmunity #Immunobiology
#InnateImmunity #Immunobiology
Reposted by Rebsamen Lab @UNIL
🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social
👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...
#LEAF #recherche #durable
👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...
#LEAF #recherche #durable
Le programme LEAF reconduit pour une nouvelle année
12 Laboratoires ont reçu une certification LEAF (Laboratory Efficiency Assessment Framework) pour leur participation au programme de mai 2024 à mai 2025.
www.unil.ch
June 5, 2025 at 7:28 AM
🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social
👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...
#LEAF #recherche #durable
👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...
#LEAF #recherche #durable
Reposted by Rebsamen Lab @UNIL
Register for this exciting meeting on Innate Immunity coming up in Switzerland! 🇨🇭
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
May 27, 2025 at 12:55 PM
Register for this exciting meeting on Innate Immunity coming up in Switzerland! 🇨🇭
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
May 1, 2025 at 11:22 AM
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Reposted by Rebsamen Lab @UNIL
Research Highlight ✨|TASL has a key role in SLE
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
March 12, 2025 at 10:19 AM
Research Highlight ✨|TASL has a key role in SLE
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Reposted by Rebsamen Lab @UNIL
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
March 2, 2025 at 3:52 PM
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Reposted by Rebsamen Lab @UNIL
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
March 8, 2025 at 2:39 PM
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
Reposted by Rebsamen Lab @UNIL
Delighted to see our latest paper selected as “Research Highlight” by @natrevrheumatol.bsky.social !
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky
March 3, 2025 at 9:39 AM
Delighted to see our latest paper selected as “Research Highlight” by @natrevrheumatol.bsky.social !
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
March 2, 2025 at 3:52 PM
🚨Registrations are open🚨
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.
Attendance is limited to 150 participants!
Reposted by Rebsamen Lab @UNIL
I'm really excited to join the University of Geneva as associate professor. I look forward to expanding our research program in systems immunology within the Department of Pathology and Immunology and contributing to advance the Faculty's data science capabilities!
JOB OPPORTUNITY👇
JOB OPPORTUNITY👇
February 28, 2025 at 3:40 PM
I'm really excited to join the University of Geneva as associate professor. I look forward to expanding our research program in systems immunology within the Department of Pathology and Immunology and contributing to advance the Faculty's data science capabilities!
JOB OPPORTUNITY👇
JOB OPPORTUNITY👇
Reposted by Rebsamen Lab @UNIL
#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
February 26, 2025 at 8:34 PM
#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social
www.nature.com/articles/s41...
Reposted by Rebsamen Lab @UNIL
Chaque franc investi par @etatdevaud.bsky.social dans @unil.bsky.social en génère 4,7 dans le canton
www.vd.ch/actualites/c...
www.vd.ch/actualites/c...
Chaque franc investi par l’État de Vaud dans l’Université de Lausanne en génère 4,7 dans le canton | État de Vaud
L’activité de l’Université de Lausanne et sa présence dans le canton génèrent près de 9200 emplois et des retombées économiques de 1,73 milliard de francs. Une étude réalisée par…
www.vd.ch
February 18, 2025 at 5:18 PM
Chaque franc investi par @etatdevaud.bsky.social dans @unil.bsky.social en génère 4,7 dans le canton
www.vd.ch/actualites/c...
www.vd.ch/actualites/c...
Reposted by Rebsamen Lab @UNIL
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Leslie Domínguez Cadena and Antje Blumenthal discuss new study from @lbernaleau.bsky.social et al. @@rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) in Insights: https://buff.ly/4gwjt5N
February 12, 2025 at 7:19 PM
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Leslie Domínguez Cadena and Antje Blumenthal discuss new study from @lbernaleau.bsky.social et al. @@rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) in Insights: https://buff.ly/4gwjt5N
Reposted by Rebsamen Lab @UNIL
💡 At a joint press conference, the #SNSF and its ERI partners called on the Federal Council to abandon the planned cuts to #education, #research and #innovation in the "relief package 27", as they would have far-reaching consequences for the #economy and society.
➡️ https://buff.ly/3CTR2AM
➡️ https://buff.ly/3CTR2AM
February 11, 2025 at 11:42 AM
💡 At a joint press conference, the #SNSF and its ERI partners called on the Federal Council to abandon the planned cuts to #education, #research and #innovation in the "relief package 27", as they would have far-reaching consequences for the #economy and society.
➡️ https://buff.ly/3CTR2AM
➡️ https://buff.ly/3CTR2AM
Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
February 10, 2025 at 2:05 PM
Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Reposted by Rebsamen Lab @UNIL
This report investigates the effect of 21 variants in the hSLC39A8 gene experimentally on protein expression, localization, and uptake of metal ions, and computationally on dimerization stability RESOLUTE and REsolution the @supertifurgalab.bsky.social at CeMM https://buff.ly/4aHOzG3
February 7, 2025 at 4:01 PM
This report investigates the effect of 21 variants in the hSLC39A8 gene experimentally on protein expression, localization, and uptake of metal ions, and computationally on dimerization stability RESOLUTE and REsolution the @supertifurgalab.bsky.social at CeMM https://buff.ly/4aHOzG3
Reposted by Rebsamen Lab @UNIL
Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N
February 5, 2025 at 8:23 PM
Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Reposted by Rebsamen Lab @UNIL
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...