Priya R Banerjee
@priya-r-banerjee.bsky.social
Associate Prof. at U Buffalo; learning how macromolecular phase transitions program cellular functions; single-molecule biophysics; disordered proteins; origin of life and RNA.
Laboratory webpage: https://www.banerjeelab.org/
Laboratory webpage: https://www.banerjeelab.org/
📢 Abstract deadline Nov 1!
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Phase Transitions in Cellular Signaling and Disease.
Explore biomolecular condensates, phase transitions, and drug discovery in Florida. Hear from experts, attend workshops, and advance your research!
events.faseb.org
October 27, 2025 at 1:38 PM
📢 Abstract deadline Nov 1!
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Reposted by Priya R Banerjee
Biomolecular condensates are shape shifting bits of DNA, RNA and proteins that “condense” molecules to key locations inside our cells. I call em "power blobs" cuz I'm fun like that. 🧪 🩺 Research from @rohitpappu68.bsky.social with @stjuderesearch.bsky.social
source.washu.edu/2025/05/rese...
source.washu.edu/2025/05/rese...
Research untangles role of stress granules in neurodegenerative disease
Researchers at Washington University in St. Louis and St. Jude Children’s Research Hospital have found that biomolecular condensates play a role in suppressing the effects of ALS-causing mutations.
source.washu.edu
May 29, 2025 at 3:59 PM
Biomolecular condensates are shape shifting bits of DNA, RNA and proteins that “condense” molecules to key locations inside our cells. I call em "power blobs" cuz I'm fun like that. 🧪 🩺 Research from @rohitpappu68.bsky.social with @stjuderesearch.bsky.social
source.washu.edu/2025/05/rese...
source.washu.edu/2025/05/rese...
Reposted by Priya R Banerjee
We find that condensate interfaces catalyze nucleation of fibrils (as shown by Paolo Arosio, Evan Spruijt, Cliff Brangwynne) but that the interiors of condensates suppress fibril formation and growth. The fibrils grow from the dilute phase! Stabilizing condensates suppresses fibril growth.
May 29, 2025 at 2:32 PM
We find that condensate interfaces catalyze nucleation of fibrils (as shown by Paolo Arosio, Evan Spruijt, Cliff Brangwynne) but that the interiors of condensates suppress fibril formation and growth. The fibrils grow from the dilute phase! Stabilizing condensates suppresses fibril growth.
Reposted by Priya R Banerjee
Postdocs @tapojyotidas.bsky.social and Fatima Zaidi from my lab tackled this question with Mina Farag and Kiersten Ruff in Rohit's lab. @priya-r-banerjee.bsky.social and Tharun Mahendran and Anruag Singh came up with a neat condensate efflux assay. Collaboration with Paul Taylor on cellular data.
May 29, 2025 at 2:28 PM
Postdocs @tapojyotidas.bsky.social and Fatima Zaidi from my lab tackled this question with Mina Farag and Kiersten Ruff in Rohit's lab. @priya-r-banerjee.bsky.social and Tharun Mahendran and Anruag Singh came up with a neat condensate efflux assay. Collaboration with Paul Taylor on cellular data.
Reposted by Priya R Banerjee
Are stress granules crucibles or protective against amyloid fibril formation? Read about our work at Mol Cell: "Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation". Wonderful collaboration with @rohitpappu68.bsky.social and other colleagues (see next post)!
May 29, 2025 at 2:23 PM
Are stress granules crucibles or protective against amyloid fibril formation? Read about our work at Mol Cell: "Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation". Wonderful collaboration with @rohitpappu68.bsky.social and other colleagues (see next post)!
Reposted by Priya R Banerjee
Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122
May 28, 2025 at 7:27 PM
Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122
Reposted by Priya R Banerjee
With @tanjamittag.bsky.social we asked if A1-LCD condensates are protective or crucibles for amyloid fibril formation. Their interfaces enable fibril nucleation but their interiors suppress fibril formation. Insights were transferrable to stress granules in cells.
doi.org/10.1016/j.mo...
doi.org/10.1016/j.mo...
Redirecting
doi.org
May 28, 2025 at 3:42 PM
With @tanjamittag.bsky.social we asked if A1-LCD condensates are protective or crucibles for amyloid fibril formation. Their interfaces enable fibril nucleation but their interiors suppress fibril formation. Insights were transferrable to stress granules in cells.
doi.org/10.1016/j.mo...
doi.org/10.1016/j.mo...
Reposted by Priya R Banerjee
Using kinetic models inspired by Tuomas Knowles, we predicted that efflux of material from metastable condensates becomes rate-limiting for fibril formation. Efflux slows as metastability increases. Experiments with @priya-r-banerjee.bsky.social confirmed these predictions.
May 28, 2025 at 3:42 PM
Using kinetic models inspired by Tuomas Knowles, we predicted that efflux of material from metastable condensates becomes rate-limiting for fibril formation. Efflux slows as metastability increases. Experiments with @priya-r-banerjee.bsky.social confirmed these predictions.
Reposted by Priya R Banerjee
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
May 23, 2025 at 3:01 PM
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
In our new preprint, we study the physical aging of biochemically active condensates of an engineered Tau protein into disease-linked fibrils — and investigate whether small molecules can counteract this transition.
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
@priya-r-banerjee.bsky.social
biorxiv.org/content/10.1101/2025.03.18.643977v1
🧵1/3
April 2, 2025 at 11:02 AM
Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
Reposted by Priya R Banerjee
#preprint Postdoc Nirbhik Acharya used NMR to find three transient helices within intrinsically-disordered regions of shuttle protein Dsk2 -- these interact with STI1. The STI1 is important for phase separation and proteasome condensates in yeast. Comments welcome!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
www.biorxiv.org
March 18, 2025 at 12:40 AM
#preprint Postdoc Nirbhik Acharya used NMR to find three transient helices within intrinsically-disordered regions of shuttle protein Dsk2 -- these interact with STI1. The STI1 is important for phase separation and proteasome condensates in yeast. Comments welcome!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Priya R Banerjee
check out the latest from Kiersten Ruff, Rohit Pappu and team!
a molecular logic for protein disordered domains 🤩
a molecular logic for protein disordered domains 🤩
March 1, 2025 at 12:19 PM
check out the latest from Kiersten Ruff, Rohit Pappu and team!
a molecular logic for protein disordered domains 🤩
a molecular logic for protein disordered domains 🤩
Reposted by Priya R Banerjee
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 6, 2025 at 10:10 PM
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Priya R Banerjee
Second new preprint ‼️ Work led by brilliant postdoc @alinaemelianova.bsky.social (in collab with Pablo Garcia and Daniel Tan) where we leverage multiscale simulations to predict small-molecule partitioning into condensates 💦💊🙌🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Prediction of small-molecule partitioning into biomolecular condensates from simulation
Predicting small-molecule partitioning into biomolecular condensates is key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-molecul...
www.biorxiv.org
March 7, 2025 at 1:44 AM
Second new preprint ‼️ Work led by brilliant postdoc @alinaemelianova.bsky.social (in collab with Pablo Garcia and Daniel Tan) where we leverage multiscale simulations to predict small-molecule partitioning into condensates 💦💊🙌🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Priya R Banerjee
In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin
Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
March 7, 2025 at 11:09 AM
In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin
Reposted by Priya R Banerjee
CALVADOS-RNA is now published
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
February 26, 2025 at 7:09 PM
CALVADOS-RNA is now published
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
doi.org/10.1021/acs....
This is a simple model for flexible RNA that complements and works with the CALVADOS protein model. Work led by Ikki Yasuda who visited us from Keio University.
Try it yourself using our latest code for CALVADOS
github.com/KULL-Centre/...
New preprint in collaboration with @jerelleaj.bsky.social!! We show that the 2’-OH group of ribose sugar plays a crucial role in RNA condensation, while its absence in DNA inhibits phase separation and percolation, a transition linked to condensate arrest. 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
February 28, 2025 at 2:36 AM
New preprint in collaboration with @jerelleaj.bsky.social!! We show that the 2’-OH group of ribose sugar plays a crucial role in RNA condensation, while its absence in DNA inhibits phase separation and percolation, a transition linked to condensate arrest. 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Great presentations from the group (www.banerjeelab.org) at #2025BPS so far.
Congratulations to Tharun Mahendran on winning Student Research Achievement Award last night. 👏👏
Tharun will present his poster on "small molecule mediated inhibition of Tau condensate aging" on Wednesday morning.
Congratulations to Tharun Mahendran on winning Student Research Achievement Award last night. 👏👏
Tharun will present his poster on "small molecule mediated inhibition of Tau condensate aging" on Wednesday morning.
February 18, 2025 at 5:26 PM
Great presentations from the group (www.banerjeelab.org) at #2025BPS so far.
Congratulations to Tharun Mahendran on winning Student Research Achievement Award last night. 👏👏
Tharun will present his poster on "small molecule mediated inhibition of Tau condensate aging" on Wednesday morning.
Congratulations to Tharun Mahendran on winning Student Research Achievement Award last night. 👏👏
Tharun will present his poster on "small molecule mediated inhibition of Tau condensate aging" on Wednesday morning.
Reposted by Priya R Banerjee
For our first scientific session spotlight we are "Peeking away from the lampost" with Dr. Rohit Pappu as he joins us to discuss intrinsically disordered proteins. @rohitpappu68.bsky.social @biophysicalsoc.bsky.social #bps2025 youtu.be/pAP2lBWBiGU
Intrinsically Disordered Proteins: A Peek Away from the Lampost
YouTube video by WebsEdge Science
youtu.be
February 17, 2025 at 11:02 AM
For our first scientific session spotlight we are "Peeking away from the lampost" with Dr. Rohit Pappu as he joins us to discuss intrinsically disordered proteins. @rohitpappu68.bsky.social @biophysicalsoc.bsky.social #bps2025 youtu.be/pAP2lBWBiGU
If you are at #BPS2025, check out these 4 posters from the group.
(1) co-condensation grammar of prion-like domains;
(2) Intra-condensate RNA aggregation;
(3) small molecule mediated inhibition of Tau condensate aging;
(4) the latest updates on our nano-rheology tools for condensates.
(1) co-condensation grammar of prion-like domains;
(2) Intra-condensate RNA aggregation;
(3) small molecule mediated inhibition of Tau condensate aging;
(4) the latest updates on our nano-rheology tools for condensates.
February 16, 2025 at 2:59 PM
If you are at #BPS2025, check out these 4 posters from the group.
(1) co-condensation grammar of prion-like domains;
(2) Intra-condensate RNA aggregation;
(3) small molecule mediated inhibition of Tau condensate aging;
(4) the latest updates on our nano-rheology tools for condensates.
(1) co-condensation grammar of prion-like domains;
(2) Intra-condensate RNA aggregation;
(3) small molecule mediated inhibition of Tau condensate aging;
(4) the latest updates on our nano-rheology tools for condensates.