@phdgenomics.bsky.social
Reposted
Science does not work like this. The only way you can set a timeline is if you have rigged the results in advance.
April 10, 2025 at 9:55 PM
Science does not work like this. The only way you can set a timeline is if you have rigged the results in advance.
Reposted
Point-of-care diagnosis of TB in 1 hour without need for sputum for $3 that can be performed anywhere (such a test does not exist); work supported by NIH
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 11, 2025 at 1:34 PM
Point-of-care diagnosis of TB in 1 hour without need for sputum for $3 that can be performed anywhere (such a test does not exist); work supported by NIH
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
You’d think when you’re claiming the richest country in the world can’t afford childhood cancer research you might wait a year before throwing yourself a 100 million dollar birthday parade. But carpe diem, suckers.
April 8, 2025 at 3:10 PM
You’d think when you’re claiming the richest country in the world can’t afford childhood cancer research you might wait a year before throwing yourself a 100 million dollar birthday parade. But carpe diem, suckers.
Reposted
Nvidia continues to bet on synthetic data as the amount of fresh real data to train AI begins to dwindle.
There are some real concerns about training on synthetic data, but there is also some exciting areas like digital twins for medical AI.
There are some real concerns about training on synthetic data, but there is also some exciting areas like digital twins for medical AI.
Nvidia Bets Big on Synthetic Data
Nvidia has acquired synthetic data startup Gretel to bolster the AI training data used by the chip maker's customers and developers.
www.wired.com
March 20, 2025 at 1:19 PM
Nvidia continues to bet on synthetic data as the amount of fresh real data to train AI begins to dwindle.
There are some real concerns about training on synthetic data, but there is also some exciting areas like digital twins for medical AI.
There are some real concerns about training on synthetic data, but there is also some exciting areas like digital twins for medical AI.
Reposted
A paper in Nature describes the discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens. The drug, named mandimycin, is a member of a known family of bacterial products with antifungal properties, the polyene macrolides. 🧪
A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature
Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.
go.nature.com
March 20, 2025 at 1:21 PM
A paper in Nature describes the discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens. The drug, named mandimycin, is a member of a known family of bacterial products with antifungal properties, the polyene macrolides. 🧪
Reposted
How can B cells rapidly proliferate and have mutations suppressed? A longstanding mystery solved involving transient mutation suppression capability of germinal centers
nature.com/articles/s41...
www.nature.com/articles/s41...
nature.com/articles/s41...
www.nature.com/articles/s41...
Regulated somatic hypermutation enhances antibody affinity maturation - Nature
Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.
nature.com
March 19, 2025 at 7:56 PM
How can B cells rapidly proliferate and have mutations suppressed? A longstanding mystery solved involving transient mutation suppression capability of germinal centers
nature.com/articles/s41...
www.nature.com/articles/s41...
nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
What is the threshold of alcohol intake that poses health risk?
A new feature @nature.com
www.nature.com/articles/d41...
open-access
A new feature @nature.com
www.nature.com/articles/d41...
open-access
March 11, 2025 at 1:57 PM
What is the threshold of alcohol intake that poses health risk?
A new feature @nature.com
www.nature.com/articles/d41...
open-access
A new feature @nature.com
www.nature.com/articles/d41...
open-access
Reposted
Friendly reminder: if you are waiting on something from a US-based scientist/reviewer/editor, please realize that we're barely making it through each day putting out non-stop fires and trying not to collapse into tears. We're trying our best, but things will take longer right now. Give grace.
March 3, 2025 at 7:22 PM
Friendly reminder: if you are waiting on something from a US-based scientist/reviewer/editor, please realize that we're barely making it through each day putting out non-stop fires and trying not to collapse into tears. We're trying our best, but things will take longer right now. Give grace.
Reposted
If you’re wondering why I declined to talk to the NYTimes, then you haven’t been following my account for very long.
They bear a direct responsibility for the current situation we find ourselves in, and I responded by laying out my position and that I would only talk to @jamellebouie.net
They bear a direct responsibility for the current situation we find ourselves in, and I responded by laying out my position and that I would only talk to @jamellebouie.net
February 20, 2025 at 11:37 PM
If you’re wondering why I declined to talk to the NYTimes, then you haven’t been following my account for very long.
They bear a direct responsibility for the current situation we find ourselves in, and I responded by laying out my position and that I would only talk to @jamellebouie.net
They bear a direct responsibility for the current situation we find ourselves in, and I responded by laying out my position and that I would only talk to @jamellebouie.net
Reposted
The root that tears apart your foundation begins as a seed of distrust, hate, and blame.
The seed that grew into a dictatorship in Europe didn’t arrive overnight.
It started with everyday Germans mad about inflation and looking for someone to blame.
The seed that grew into a dictatorship in Europe didn’t arrive overnight.
It started with everyday Germans mad about inflation and looking for someone to blame.
February 19, 2025 at 6:44 PM
The root that tears apart your foundation begins as a seed of distrust, hate, and blame.
The seed that grew into a dictatorship in Europe didn’t arrive overnight.
It started with everyday Germans mad about inflation and looking for someone to blame.
The seed that grew into a dictatorship in Europe didn’t arrive overnight.
It started with everyday Germans mad about inflation and looking for someone to blame.
Reposted
Developmental gene expression patterns driving species-specific cortical features https://www.biorxiv.org/content/10.1101/2025.02.18.638637v1
February 19, 2025 at 4:17 AM
Developmental gene expression patterns driving species-specific cortical features https://www.biorxiv.org/content/10.1101/2025.02.18.638637v1
Reposted
Firings are happening right now at the National Science Foundation. Essential staff are being cut.
This isn’t about the budget. If it was, they’d be going after the military (17%) or state appropriations (38%). NSF is 0.7% of the federal budget. All federal employees make up only 4% of the budget.
This isn’t about the budget. If it was, they’d be going after the military (17%) or state appropriations (38%). NSF is 0.7% of the federal budget. All federal employees make up only 4% of the budget.
February 18, 2025 at 5:45 PM
Firings are happening right now at the National Science Foundation. Essential staff are being cut.
This isn’t about the budget. If it was, they’d be going after the military (17%) or state appropriations (38%). NSF is 0.7% of the federal budget. All federal employees make up only 4% of the budget.
This isn’t about the budget. If it was, they’d be going after the military (17%) or state appropriations (38%). NSF is 0.7% of the federal budget. All federal employees make up only 4% of the budget.
Reposted
Ensemble Post-hoc Explainable AI in Multivariate Time Series: Identifying Medical Features Driving Disease Prediction https://www.biorxiv.org/content/10.1101/2025.02.14.638219v1
February 19, 2025 at 2:48 AM
Ensemble Post-hoc Explainable AI in Multivariate Time Series: Identifying Medical Features Driving Disease Prediction https://www.biorxiv.org/content/10.1101/2025.02.14.638219v1
Reposted
Out of the 12,000 civil rights complaints the Education Department has put on hold since Trump took office:
• 6,000 relate to mistreatment of disabled students
• 1,000 are specific to sexual harassment/violence
• 3,200 pertain to racial discrimination
• 6,000 relate to mistreatment of disabled students
• 1,000 are specific to sexual harassment/violence
• 3,200 pertain to racial discrimination
“We’ve Been Essentially Muzzled”: Department of Education Halts Thousands of Civil Rights Investigations Under Trump
Since Inauguration Day, the Office for Civil Rights has only opened about 20 investigations focused on Trump’s priorities, placing more than 10,000 student complaints related to disability access and…
propub.li
February 19, 2025 at 3:00 AM
Out of the 12,000 civil rights complaints the Education Department has put on hold since Trump took office:
• 6,000 relate to mistreatment of disabled students
• 1,000 are specific to sexual harassment/violence
• 3,200 pertain to racial discrimination
• 6,000 relate to mistreatment of disabled students
• 1,000 are specific to sexual harassment/violence
• 3,200 pertain to racial discrimination
Reposted
A paper in Nature Cancer presents an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, which was used to identify key prognostic marker interactions and confirmed in an external lung cancer cohort. 🧪
Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence - Nature Cancer
Keyl et al. present an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, identified key prognostic marker interactions, and con...
go.nature.com
February 13, 2025 at 5:53 PM
A paper in Nature Cancer presents an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, which was used to identify key prognostic marker interactions and confirmed in an external lung cancer cohort. 🧪
Reposted
Getting to the bottom of cancer surging in the young
—Tumor age
www.cell.com/cell/fulltex...
—The mystery
time.com/7213490/why-...
—Tumor age
www.cell.com/cell/fulltex...
—The mystery
time.com/7213490/why-...
February 13, 2025 at 4:24 PM
Getting to the bottom of cancer surging in the young
—Tumor age
www.cell.com/cell/fulltex...
—The mystery
time.com/7213490/why-...
—Tumor age
www.cell.com/cell/fulltex...
—The mystery
time.com/7213490/why-...
Reposted
🧠 Massive gene expression changes in Alzheimer’s disease
A new study suggests that widespread changes in gene activity might be the unifying factor in Alzheimer’s pathology.
Could this help with earlier detection?
🔗 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#Alzheimers 🧪 #SciComm
A new study suggests that widespread changes in gene activity might be the unifying factor in Alzheimer’s pathology.
Could this help with earlier detection?
🔗 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#Alzheimers 🧪 #SciComm
Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer's disease
Understanding of the biology of Alzheimer's disease (AD) has long been fragmented, with various investigators concentrating on amyloid beta (Aβ) or tau, inflammation, cell death pathways, misfolded .....
alz-journals.onlinelibrary.wiley.com
February 12, 2025 at 5:16 PM
🧠 Massive gene expression changes in Alzheimer’s disease
A new study suggests that widespread changes in gene activity might be the unifying factor in Alzheimer’s pathology.
Could this help with earlier detection?
🔗 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#Alzheimers 🧪 #SciComm
A new study suggests that widespread changes in gene activity might be the unifying factor in Alzheimer’s pathology.
Could this help with earlier detection?
🔗 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#Alzheimers 🧪 #SciComm
Reposted
New A.I. models in spatial omics
—singe cell GPT @bowang87.bsky.social
www.biorxiv.org/content/10.1...
—CORAL @jameszou.bsky.social
www.biorxiv.org/content/10.1...
These are coming along incredibly fast and helping us learn the language of life
www.science.org/doi/10.1126/... @science.org
—singe cell GPT @bowang87.bsky.social
www.biorxiv.org/content/10.1...
—CORAL @jameszou.bsky.social
www.biorxiv.org/content/10.1...
These are coming along incredibly fast and helping us learn the language of life
www.science.org/doi/10.1126/... @science.org
February 9, 2025 at 9:51 PM
New A.I. models in spatial omics
—singe cell GPT @bowang87.bsky.social
www.biorxiv.org/content/10.1...
—CORAL @jameszou.bsky.social
www.biorxiv.org/content/10.1...
These are coming along incredibly fast and helping us learn the language of life
www.science.org/doi/10.1126/... @science.org
—singe cell GPT @bowang87.bsky.social
www.biorxiv.org/content/10.1...
—CORAL @jameszou.bsky.social
www.biorxiv.org/content/10.1...
These are coming along incredibly fast and helping us learn the language of life
www.science.org/doi/10.1126/... @science.org
Reposted
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
Reposted
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
February 8, 2025 at 1:45 PM
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
Reposted
The Papua New Guinea Courier is in rare form.
February 6, 2025 at 12:31 PM
The Papua New Guinea Courier is in rare form.
Reposted
ah trump’s merit in action. only certain people can be meritorious
Just in case you thought that removing DEI criteria would mean that everyone is competing equally: NIH is removing grad students from underrepresented backgrounds from the applicant pool altogether. Their applications will not be considered. Other students, not from these backgrounds, will be.
February 6, 2025 at 9:58 PM
ah trump’s merit in action. only certain people can be meritorious
Reposted
This week's editorial and cover at @thelancet.bsky.social
www.thelancet.com/journals/lan...
"The past 3 weeks have generated much anger, fear,
and sorrow—but it is no time for panic. The medical and
scientific communities must come together and stand
up for this vision."
www.thelancet.com/journals/lan...
"The past 3 weeks have generated much anger, fear,
and sorrow—but it is no time for panic. The medical and
scientific communities must come together and stand
up for this vision."
February 7, 2025 at 12:13 AM
This week's editorial and cover at @thelancet.bsky.social
www.thelancet.com/journals/lan...
"The past 3 weeks have generated much anger, fear,
and sorrow—but it is no time for panic. The medical and
scientific communities must come together and stand
up for this vision."
www.thelancet.com/journals/lan...
"The past 3 weeks have generated much anger, fear,
and sorrow—but it is no time for panic. The medical and
scientific communities must come together and stand
up for this vision."
Reposted
I counted the number of times that words from the NSF flagged words list were included in my final dissertation document, and the answer is 1530.
February 6, 2025 at 1:23 AM
I counted the number of times that words from the NSF flagged words list were included in my final dissertation document, and the answer is 1530.